Protein Alignment SLC5A6 and slc-5A12

DIOPT Version :10

• Sequence 1: NP_066918.2
• Gene: SLC5A6 / 8884
• HGNCID: 11041
• Length: 635
• Species: Homo sapiens
• Sequence 2: NP_001041067.1
• Gene: slc-5A12 / 178127
• WormBaseID: WBGene00014092
• Length: 577
• Species: Caenorhabditis elegans
• Alignment Length: 553
• Identity: 176/553 - (31%)
• Similarity: 285/553 - (51%)
• Gaps: 55/553 - (9%)

Human    27 MDYVVFVLLLVLSLAIGLYHA------CRGWGRHTVGELLMADRKMGCLPVALSLLATFQSAVAI 85
            :||.:|.|.:.|||:.|:|||      .|...|....|.||..|::..||||||||.||.|.:.:
 Worm    10 LDYAIFGLSIGLSLSTGVYHAIKSRIILRRGDRTAKEEYLMGGRQLPPLPVALSLLTTFLSGILM 74

Human    86 LGVPSEIYRFGTQYWFLGCCYFLGL---LIPAHIFIPVFYRLHLTSAYEYLELRFNK-TVRVCGT 146
            ||||:|:::.|.|.|.   .:.:|:   ::...:|:|||:::..|..:||...|:|. .:|...:
 Worm    75 LGVPAEMFQRGAQIWL---NFVIGVASSIVTCFVFLPVFHKMKSTCLHEYFIHRYNSILIRRLFS 136

Human   147 VTFIFQMVIYMGVVLYAPSLALNAVTGFDLWLSVLALGIVCTVYTALGGLKAVIWTDVFQTLVMF 211
            :.|:...::||.|||||||:||:.|...:.|..||..|...|:||.|||||||:|||..|.::|:
 Worm   137 LLFLLFTIVYMSVVLYAPSVALSPVLQINKWYLVLIFGCTTTLYTCLGGLKAVVWTDSLQAVIMY 201

Human   212 LGQLAVIIVGSA--KVGGLGRVWAVASQHGRIS-----GFELDPDPFVRHTFWTLAFGGVFMMLS 269
            .|...:|..|.:  :||||.||.::|...||||     .:.:|.    .::.|...|.|..:.|:
 Worm   202 TGVFTLIYKGLSHPRVGGLERVLSIAWDSGRISELGRMDWRIDQ----YNSLWINLFSGTIVWLA 262

Human   270 LYGVNQAQVQRYLSSRTEKAA-VLSCYAVFPFQQVSLC-VGCLIGLVMFAY-YQEYPMSIQQAQA 331
            .:||||..:|||.|..:.|.| .:..|.:.||  ..|| :...:|.:..|| |...|:...:.:.
 Worm   263 SFGVNQLAIQRYASLPSLKVAQSIIIYTLAPF--TVLCSIVAFVGFIALAYFYNCNPLETGEVKE 325

Human   332 APDQFVLYFVMDLLKGLPGLPGLFIACLFSGSLSTISSAFNSLATVTMEDLIRPWFP-EFSEARA 395
            : |...:.|..|:|:..|||.||:::|:.|.:|||:||..||:|....||.::.... :.::..|
 Worm   326 S-DHITISFARDILQPTPGLFGLYVSCIMSATLSTLSSGMNSMAAAIYEDFLKNSLDGKITDTGA 389

Human   396 IMLSRGLAFGYGLLCLGMAYISSQMGPVLQAAISIFGMVGGPLLGLFCLGMFFPCANPPGAVVGL 460
            ..|::.:....||...|:|:::..:|..|:..||:.|.:.||::.:|.|.:|||.:.....::..
 Worm   390 TRLNKIIVLICGLSSTGLAFLAEVLGGSLRICISVMGAMSGPMVAIFVLALFFPKSGSKSCLISF 454

Human   461 LAGLVMAFWIGIGSIVTSMGSSMPPSPSNGSSFSLPTNLTVATVT-----TLMPLTTFSKPTG-- 518
            ....:....|.|.:.:        ..|.:  ...||||.|:....     |:..:.|:....|
 Worm   455 FLSNLFCLIICIANYI--------QDPYH--DLFLPTNTTLEGCNGNSNFTIRMMPTYDAHYGNP 509

Human   519 ----LQRFYSLSYLWYSAHNSTTVIVVGLIVSL 547
                :.|..:.|   |:......:|::|.|.||
 Worm   510 DTLYISRISTYS---YAGVGFVLMIIIGWIASL 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC5A6	NP_066918.2	SLC5sbd_SMVT	24..550	CDD:271394	176/553 (32%)
slc-5A12	NP_001041067.1	SLC5sbd_NIS-SMVT	11..540	CDD:271383	176/552 (32%)