DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAE1 and APP-BP1

DIOPT Version :9

Sequence 1:	NP_001273429.1	Gene:	NAE1 / 8883	HGNCID:	621	Length:	537	Species:	Homo sapiens
Sequence 2:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	238/536 - (44%)
Similarity:	339/536 - (63%)	Gaps:	32/536 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     9 KEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGNVGIGSFTIIDGNQVSGEDA 73
            |.:|||||:||||:|||..||:|.|||:|.||.|.|..|.||||   |||.||:.||:.|..||.
  Fly    14 KSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLP---GIGGFTVADGSTVKEEDL 75

Human    74 GNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPEST 138
            ||||||..|.:||::|.|.|:.|||||.||:|.:|:||.:.||.|.|:||..|.:|:|:.|.|.|
  Fly    76 GNNFFLDSSYLGKSKALACMQLLQELNPDVNGDYVDESADFLLANRPNFFDSFDLVIASNLNEQT 140

Human   139 SLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYD 203
            .|.||:.||...:||:.||:.|::|.:|:.|:||.::|:||||...||||:.||..||||....:
  Fly   141 LLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREHLDGTE 205

Human   204 LDHMEKKDHSHTPWIVIIAKYLAQWY-SETNG-RIPKTYKEKEDFRDLIRQGILKNENGAPEDEE 266
            :.       |..||::::.|||..|. .:.:| :.|:.||||...::.||:.:       ..|||
  Fly   206 VT-------SKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEM-------KADEE 256

Human   267 NFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGT 331
            |:|||||.||||....|:|.|::.||.||.|..:.|::..|||:|:|||.||..|.:|:||:.|.
  Fly   257 NYEEAIKAVNTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGV 321

Human   332 IPDMIADSGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVV 396
            :|||.|::..||.||::||::|.:||..|.:...:.|:.:....:||.|:.::|:|..:|.|.|:
  Fly   322 LPDMTANTDSYIALQHIYRQQALQDADQVYHKCQEYLKQLALPADSIDERSVRLICKEAAGLAVI 386

Human   397 RCRSLAEEYGLDTINKDEIISSMDNPDNEI-----VLYLMLRAVDRFHKQQGRYPGVSNYQVEED 456
            |...:||||.    ....::..::  |||:     .....|||.:||..:.|..||  ...||:|
  Fly   387 RGTRIAEEYE----KSSRLLPLVE--DNELQGNLTAYNFALRAYERFLSECGNIPG--ECIVEQD 443

Human   457 IGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNN 521
            ||:|||.....|.:.|:...:.||.:||.||||.||.|.::||:||.||||||||||||:...:|
  Fly   444 IGRLKSIAAKMLSDLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPIDN 508

Human   522 TYIYSGMSQTSATFQL 537
            |:||:.::..|.|.:|
  Fly   509 TFIYNAITTESVTLKL 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAE1	NP_001273429.1	ThiF	9..>196	CDD:223552	100/186 (54%)
		APPBP1_RUB	11..535	CDD:238770	235/530 (44%)
		Interaction with UBA3	334..347		6/12 (50%)
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	235/530 (44%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552	85/156 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141710
Domainoid	1	1.000	438	1.000	Domainoid score	I560
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68370
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1589
Isobase	1	0.950	-	0	Normalized mean entropy	S2092
OMA	1	1.010	-	-		QHG54417
OrthoDB	1	1.010	-	-		D393419at33208
OrthoFinder	1	1.000	-	-		FOG0003676
OrthoInspector	1	1.000	-	-		oto89761
orthoMCL	1	0.900	-	-		OOG6_101722
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1600
SonicParanoid	1	1.000	-	-		X3040
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750