DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDC16 and Cdc16

DIOPT Version :9

Sequence 1:	NP_001072113.1	Gene:	CDC16 / 8881	HGNCID:	1720	Length:	620	Species:	Homo sapiens
Sequence 2:	NP_477397.1	Gene:	Cdc16 / 42753	FlyBaseID:	FBgn0025781	Length:	718	Species:	Drosophila melanogaster

Alignment Length:	735	Identity:	268/735 - (36%)
Similarity:	391/735 - (53%)	Gaps:	157/735 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     1 MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSRKL 65
            ::|...|:.|:|::|.::|.:|||||:|||.|...||:|||:.|||:||..:||||||.::..||
  Fly    17 IDLALYRQLVKQFIDMRRYSTALFWAEKVAVLGGLEPRDIYYQAQCMYLLGEYHRAAHTIQHHKL 81

Human    66 DKLYEACRYLAARCHYAAKEHQQALDVLDMEEP-------INKRLFEK---YLKDESGFKDPSSD 120
            :|....|..|.....|||||..:|.:|:...|.       ||:.:...   ||:..|.|    ..
  Fly    82 EKNSLPCFNLLLESLYAAKEFTEAANVIQNVEVEVMTTSLINQPVDASSGCYLESNSVF----GG 142

Human   121 WEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELL 185
            .|..::.:.|||.|::||:|:|||||.:|...|.:||...:|||||.:.|..|.||.|.||.||:
  Fly   143 EENHRNELLSSIYLMKGKVYEALDNRGMAMDFYVQALHKSIYCFEALEALVQHEMLMAWEEFELM 207

Human   186 ESLPLSKLCNE-EQELLRFLFENKLKKYNK----------------------------------- 214
            ..|||::..:| :.:.:..|:|::||||.:
  Fly   208 HHLPLAQQSSEADAKFILKLYESRLKKYYELISARNAEEMSPIVNPDILQFIKEFTARVQQSGSS 272

Human   215 ---------------PS------------------------------------------------ 216
                           ||
  Fly   273 DTQMPKVSAVKVPLTPSQFMSPAQKVLEDLKAPTFSLQTSLSKASSLIDASHRSMFDSSSRRRSR 337

Human   217 ----ETVIP--ESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTL 275
                :|:||  |.:|.:|.:.|::.:.||:.:|:||:|.|.|:.:.:::.||||.:.|.:.|..|
  Fly   338 DHDTDTLIPIAECLDRVQRSTDLMAAEAEKCFYDCDYKQCLKILNELLKVDPFHNTALTIQIACL 402

Human   276 VELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAY 340
            ||....|.|||::|||||.||...:||:||||||.|:| |::.|||||||||.|::.|||||:||
  Fly   403 VENGDFNRLFYVAHKLVDRYPDKAISWYAVGCYYDMIG-KSDPARRYLSKATALDRLYGPAWLAY 466

Human   341 GHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVM 405
            |||||.|:||:|||||||.|.|||:|||||:||||:|.|||.|.:|||:||.||::|||.|.:|:
  Fly   467 GHSFANENEHEQAMAAYFKATQLMRGCHLPLLYIGVECGLTKNLELAEKFFLQAMNIAPLDVYVL 531

Human   406 HEVGVVAFQNGEWKTAEKWF---LDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDY 467
            ||:||:.::...:..|...|   :|.:::.....||....:||||..||||..||:.||.|||..
  Fly   532 HELGVIKYEYEFFDGAATIFQCTVDIVKQRAKSNNEEISSRWEPLFINLGHSLRKVHKYEEALYN 596

Human   468 HRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDS-- 530
            .:.||:|.||:.:||::||:||:|:||.:.|::.||.:|.|.||...:.|:|..|||..:.||
  Fly   597 FQYALLLKPQSPTTYTSIGFIHALLGNLDPAIEAFHKSLALNRDCIVTSTILKSCIEDLMDDSAT 661

Human   531 -EAYIGADIKDKLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRP 594
             :....|.::|             ..|||               ||....:.   .|.|....:.
  Fly   662 IDEICSAALRD-------------VAKNI---------------TANSRRVL---NSDKFNGMKL 695

Human   595 SLEETFEIEMNESDMMLETS 614
            ..:|..|...::|:|::|.|
  Fly   696 KFDEEEEFANSDSNMVVEMS 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDC16	NP_001072113.1	TPR 1	4..33		13/28 (46%)
		PEP_TPR_lipo	10..>502	CDD:274350	238/609 (39%)
		ANAPC3	15..94	CDD:403946	39/78 (50%)
		TPR repeat	36..65	CDD:276809	16/28 (57%)
		TPR 2	37..62		15/24 (63%)
		TPR repeat	70..94	CDD:276809	9/23 (39%)
		TPR 3	70..93		8/22 (36%)
		TPR 4	128..159		16/30 (53%)
		TPR 5	164..187		12/22 (55%)
		TPR 6	198..222		11/127 (9%)
		TPR 7	232..260		9/27 (33%)
		TPR 8	267..294		13/26 (50%)
		TPR repeat	298..329	CDD:276809	20/30 (67%)
		TPR 9	299..329		20/29 (69%)
		TPR 10	334..362		22/27 (81%)
		TPR repeat	336..362	CDD:276809	20/25 (80%)
		TPR repeat	367..397	CDD:276809	20/29 (69%)
		TPR 11	369..397		18/27 (67%)
		PilF	371..>511	CDD:225605	64/142 (45%)
		TPR 12	402..434		8/34 (24%)
		TPR repeat	402..430	CDD:276809	8/30 (27%)
		TPR repeat	435..474	CDD:276809	19/38 (50%)
		TPR 13	442..474		17/31 (55%)
		TPR_12	447..511	CDD:315987	31/63 (49%)
		TPR 14	479..508		13/28 (46%)
		TPR repeat	479..506	CDD:276809	12/26 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..599		4/24 (17%)
Cdc16	NP_477397.1	ANAPC3	31..112	CDD:289650	39/80 (49%)
		TPR_11	425..489	CDD:290150	44/64 (69%)
		TPR repeat	426..454	CDD:276809	19/28 (68%)
		TPR repeat	462..488	CDD:276809	20/25 (80%)
		TPR repeat	493..523	CDD:276809	20/29 (69%)
		TPR repeat	528..552	CDD:276809	6/23 (26%)
		TPR_11	576..638	CDD:290150	30/61 (49%)
		TPR repeat	576..602	CDD:276809	13/25 (52%)
		TPR repeat	607..637	CDD:276809	13/29 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147301
Domainoid	1	1.000	252	1.000	Domainoid score	I2098
eggNOG	1	0.900	-	-		E1_KOG1173
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2899
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2467
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56718
OrthoDB	1	1.010	-	-		D269745at33208
OrthoFinder	1	1.000	-	-		FOG0004793
OrthoInspector	1	1.000	-	-		oto91336
orthoMCL	1	0.900	-	-		OOG6_102501
Panther	1	1.100	-	-	LDO	PTHR12558
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R265
SonicParanoid	1	1.000	-	-		X3945
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800