Protein Alignment SGPL1 and spl-1

DIOPT Version :10

• Sequence 1: NP_001425282.1
• Gene: SGPL1 / 8879
• HGNCID: 10817
• Length: 579
• Species: Homo sapiens
• Sequence 2: NP_499913.1
• Gene: spl-1 / 176857
• WormBaseID: WBGene00004981
• Length: 552
• Species: Caenorhabditis elegans
• Alignment Length: 544
• Identity: 232/544 - (42%)
• Similarity: 330/544 - (60%)
• Gaps: 21/544 - (3%)

Human    30 VNGHCTKYEPWQLI----AWSVVWTLLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQD 90
            :|...::|:|..|:    ..::|:|.::   :.:....:.:..|.....|.|.||:|.:..||:.
 Worm    22 INDRLSRYDPVVLVLAAFGGTLVYTKVV---HLYRKSEDPILKRMGAYVFSLLRKLPAVRDKIEK 83

Human    91 KLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMASPDVNILYNHDAFWQEGR 155
            :|...|..:.:::.....||:::..||...||..:::|..|:|.     |.| .:|.|.    ||
 Worm    84 ELAAEKPKLIESIHKDDKDKQFISTLPIAPLSQDSIMELAKKYE-----DYN-TFNIDG----GR 138

Human   156 ASGTVYSGEE-KLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTS 219
            .||.||:... :...||.|.|..:|:|||||||:|||.||:|||::|:..:|:||..||.|.|||
 Worm   139 VSGAVYTDRHAEHINLLGKIYEKYAFSNPLHPDVFPGARKMEAELIRMVLNLYNGPEDSSGSVTS 203

Human   220 GGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMR 284
            ||||||:|||.:||:.|...||:.|.|:|.::|||||:|||...||::..||:.....||::.|.
 Worm   204 GGTESIIMACFSYRNRAHSLGIEHPVILACKTAHAAFDKAAHLCGMRLRHVPVDSDNRVDLKEME 268

Human   285 RAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFD 349
            |.|..|..|||.|.|.||.|.|||:||:|||..||.||:|||||||||:|.||..||| |...||
 Worm   269 RLIDSNVCMLVGSAPNFPSGTIDPIPEIAKLGKKYGIPVHVDACLGGFMIPFMNDAGY-LIPVFD 332

Human   350 FRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAA 414
            ||..||||||.||||||..|||||:|:|..|:..::|:|...||.|||||:|||||||.|..:|.
 Worm   333 FRNPGVTSISCDTHKYGCTPKGSSIVMYRSKELHHFQYFSVADWCGGIYATPTIAGSRAGANTAV 397

Human   415 CWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMT 479
            .||.|:.||.:.||....||:|..|.|..::|.||.|..:|...:|::|......:||.:|:.|.
 Worm   398 AWATLLSFGRDEYVRRCAQIVKHTRMLAEKIEKIKWIKPYGKSDVSLVAFSGNGVNIYEVSDKMM 462

Human   480 AKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQI-MKNPKAKTTGMGAIYGMAQTT 543
            ..|||||.||.|.:||.|:|:..|.:.|...|..|:.:...:: .|..:...:||.|:|||| ..
 Worm   463 KLGWNLNTLQNPAAIHICLTINQANEEVVNAFAVDLEKICEELAAKGEQKADSGMAAMYGMA-AQ 526

Human   544 VDRNMVAELSSVFLDSLYSTDTVT 567
            |.:::|.|:.::::|:.||....|
 Worm   527 VPKSVVDEVIALYIDATYSAPPST 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SGPL1	NP_001425282.1	None
spl-1	NP_499913.1	DOPA_deC_like	138..501	CDD:99743	187/363 (52%)