Protein Alignment SQSTM1 and sqstm1

DIOPT Version :10

• Sequence 1: NP_003891.1
• Gene: SQSTM1 / 8878
• HGNCID: 11280
• Length: 440
• Species: Homo sapiens
• Sequence 2: XP_017947533.1
• Gene: sqstm1 / 493277
• XenbaseID: XB-GENE-5918988
• Length: 456
• Species: Xenopus tropicalis
• Alignment Length: 473
• Identity: 252/473 - (53%)
• Similarity: 317/473 - (67%)
• Gaps: 57/473 - (12%)

Human     4 LTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYR 68
            :|||||||||:::.||||||..    |..|..:..|....||.|.::|..:|..|:.|.||..|:
 Frog     3 VTVKAYLLGKDESHREIRRFQL----ELPAAGKEKASVSSCELLANKVTGVFQGLKGGAFQMFYK 63

Human    69 DEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNG 133
            ||:|||||||:||||.|.:|.:.:|:|||||||:|||:||||..|.||.|:|:|||||.||||:|
 Frog    64 DEEGDLVAFSTDEELHMGLSLLNEDVFRIYIKERKECKRDHRGHCGQETPQNVVHPNVTCDGCDG 128

Human   134 PVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHG--HFGW- 195
            ||||.|:||.:||||||||.||.||:|:.|..:.||:|.. :.:.:..|||.||:.||  .|.|
 Frog   129 PVVGNRFKCLICPDYDLCSTCEKKGIHKEHNMIMFPTPLS-VFQVYPRSRWFRKMHHGVPPFPWM 192

Human   196 PGW----------------EMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESV 244
            .||                |..||.|.:|    |.||    .|.|.|..|::|:|.|||||||||
 Frog   193 QGWAYPPRGYPCQNFQQAQESTPPQNETP----AEEA----AATSDSQSSQNPNVAFLKNVGESV 249

Human   245 AAALSPLGIEVDIDVEHGGKRSRLT---PVS------PESSSTEEKSSSQPSSCCSDPSKPGGNV 300
            ||.||||||:|||||||||||::::   |.|      |.||::..:|....|...|.|:..
 Frog   250 AAMLSPLGIDVDIDVEHGGKRTKVSTSHPCSVDGDSQPNSSTSFTESQDIASRSDSAPNLM---- 310

Human   301 EGATQSLAEQMRKIALESEGRPEEQMESDN---CSGGDDDWTHLSSKEVDPSTGELQSLQMPESE 362
              .|:.:|::|:.|||.|. .|::..:.:|   .|||||||||:||||||||||||||||:.|:.
 Frog   311 --ETEHIAKRMKDIALNSP-LPQDNEQGENSSSASGGDDDWTHVSSKEVDPSTGELQSLQLMETG 372

Human   363 GPSSLDPSQ------EGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKN 421
            .|.||||::      ..||||:||||||||||||||||||||||||||||:||||||||||:.|.
 Frog   373 QPCSLDPTRSSALPTHAPTGLREAALYPHLPPEADPRLIESLSQMLSMGFTDEGGWLTRLLEAKQ 437

Human   422 YDIGAALDTIQYSKHPPP 439
            :|||:|||.:|..:|.||
 Frog   438 FDIGSALDAMQSIRHIPP 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SQSTM1	NP_003891.1	Interaction with LCK. /evidence=ECO:0000269|PubMed:8650207	2..50		21/45 (47%)
		PB1_p62	4..102	CDD:99723	50/97 (52%)
		Interaction with PRKCZ and dimerization. /evidence=ECO:0000250|UniProtKB:O08623	43..107		36/63 (57%)
		Interaction with PAWR. /evidence=ECO:0000269|PubMed:11755531	50..80		16/29 (55%)
		Interaction with GABRR3. /evidence=ECO:0000250|UniProtKB:O08623	122..224		54/120 (45%)
		ZZ_NBR1_like	126..168	CDD:239080	27/41 (66%)
		LIM protein-binding (LB)	170..220		20/68 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..235		15/54 (28%)
		TRAF6-binding	228..233		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..390		65/143 (45%)
		Interaction with NTRK1. /evidence=ECO:0000250|UniProtKB:O08623	269..440		102/189 (54%)
		MAP1LC3B-binding. /evidence=ECO:0000269|PubMed:17580304	321..342		11/23 (48%)
		LIR	336..341		4/4 (100%)
		Interaction with KEAP1. /evidence=ECO:0000269|PubMed:20452972	347..352		4/4 (100%)
		UBA_5	379..440	CDD:318725	49/61 (80%)
sqstm1	XP_017947533.1	PB1_p62	3..96	CDD:99723	49/96 (51%)
		ZZ_NBR1_like	121..163	CDD:239080	27/41 (66%)
		UBA_like_SF	395..455	CDD:473871	47/59 (80%)