Protein Alignment SQSTM1 and sqstm1

DIOPT Version :10

• Sequence 1: NP_003891.1
• Gene: SQSTM1 / 8878
• HGNCID: 11280
• Length: 440
• Species: Homo sapiens
• Sequence 2: NP_001299842.1
• Gene: sqstm1 / 406452
• ZFINID: ZDB-GENE-040426-2204
• Length: 452
• Species: Danio rerio
• Alignment Length: 483
• Identity: 225/483 - (46%)
• Similarity: 289/483 - (59%)
• Gaps: 84/483 - (17%)

Human     3 SLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHY 67
            |:||||||:||||..:|||||:        .:.:.:..   .|.|..:|..:|..||...||.:|
Zfish     2 SMTVKAYLIGKEDCNKEIRRFA--------VDQDVSTS---FEYLQRKVLDVFVGLRTAPFQMYY 55

Human    68 RDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRP-----------------PC-- 113
            :|||||::|||||:||.|.::.||||.||::||::||.:||..|                 ||
Zfish    56 KDEDGDMIAFSSDDELMMGLALVKDDTFRLFIKQRKEHKRDSSPHGIPGFPFTTPHFSPPGPCHM 120

Human   114 ---------------AQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGH 163
                           ....|..||||.|.||||:|||.||||||:||||||||..|:.||||:.|
Zfish   121 GPSPMGPPGPPHMGGPPHHPHPMVHPGVTCDGCDGPVAGTRYKCTVCPDYDLCPTCQSKGLHKEH 185

Human   164 TKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASG- 227
            ..|....|..::.|.....::.||::  |..|...:........|.|..|.:.:..|...:.:|
Zfish   186 ALLPIFHPMANVFEWLPRGKFWRKMR--HCMWANAQAQAQNQPQPGPSGAQQNQDAPENPNENGA 248

Human   228 -PSEDPSVNFLKNVGESVAAALSPLGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCS 291
             .|...:|.:|||:||.|||.||||||:|||||||.|||:::||..|        :||.|||..|
Zfish   249 TASSQANVEYLKNIGEEVAAMLSPLGIDVDIDVEHEGKRTKVTPTPP--------ASSGPSSARS 305

Human   292 DPSKPG----GNVEGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPSTGE 352
            |....|    |:..| :|:..|.:      |||     .:.|.||  |::|||||:|||||||||
Zfish   306 DSGSVGLLSRGSGPG-SQATEESV------SEG-----TKKDQCS--DEEWTHLSAKEVDPSTGE 356

Human   353 LQSLQMPESEG---PSSLD-----PSQEGPTGLKEAALYPHLPPEADPRLIESLSQMLSMGFSDE 409
            ||||:: |.:|   |:.|:     .:::|||||:|||||||||.:|||||:|||||||||||:||
Zfish   357 LQSLRL-EQDGADLPAPLNTASGTSTRDGPTGLREAALYPHLPQDADPRLVESLSQMLSMGFTDE 420

Human   410 GGWLTRLLQTKNYDIGAALDTIQYSKHP 437
            ||||||||.|||||||.|||||||||.|
Zfish   421 GGWLTRLLHTKNYDIGGALDTIQYSKTP 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SQSTM1	NP_003891.1	Interaction with LCK. /evidence=ECO:0000269|PubMed:8650207	2..50		18/46 (39%)
		PB1_p62	4..102	CDD:99723	45/97 (46%)
		Interaction with PRKCZ and dimerization. /evidence=ECO:0000250|UniProtKB:O08623	43..107		32/63 (51%)
		Interaction with PAWR. /evidence=ECO:0000269|PubMed:11755531	50..80		15/29 (52%)
		Interaction with GABRR3. /evidence=ECO:0000250|UniProtKB:O08623	122..224		42/101 (42%)
		ZZ_NBR1_like	126..168	CDD:239080	29/41 (71%)
		LIM protein-binding (LB)	170..220		9/49 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..235		6/40 (15%)
		TRAF6-binding	228..233		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..390		60/137 (44%)
		Interaction with NTRK1. /evidence=ECO:0000250|UniProtKB:O08623	269..440		101/181 (56%)
		MAP1LC3B-binding. /evidence=ECO:0000269|PubMed:17580304	321..342		7/20 (35%)
		LIR	336..341		2/4 (50%)
		Interaction with KEAP1. /evidence=ECO:0000269|PubMed:20452972	347..352		4/4 (100%)
		UBA_5	379..440	CDD:318725	52/59 (88%)
sqstm1	NP_001299842.1	PB1_p62	3..88	CDD:99723	43/95 (45%)
		ZZ_NBR1_like	148..190	CDD:239080	29/41 (71%)
		UBA_like_SF	390..448	CDD:473871	51/57 (89%)