DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SQSTM1 and ref(2)P

DIOPT Version :9

Sequence 1:	NP_003891.1	Gene:	SQSTM1 / 8878	HGNCID:	11280	Length:	440	Species:	Homo sapiens
Sequence 2:	NP_001014491.1	Gene:	ref(2)P / 35246	FlyBaseID:	FBgn0003231	Length:	599	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	115/510 - (22%)
Similarity:	167/510 - (32%)	Gaps:	177/510 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    99 IKEKKECRRDHRPPCAQ----EAPRNM-VHPNVICDGCN-GPVVGTRYKCSVCPDYDLCSVCEGK 157
            ::|.|..:::.....|:    :.|.|. :|..|.||||. .|::|.||||..|.:||||..||..
  Fly    93 VEEPKATKQEGSSANAEAPSVDDPSNFTIHDAVECDGCGLAPLIGFRYKCVQCSNYDLCQKCELA 157

Human   158 GLHRGHTKLAFPS----------------------------PFGHLS------EGFSHSRWLRKV 188
            ..|..|..|..|:                            ||...:      |....||..|:.
  Fly   158 HKHPEHLMLRMPTNNGPGMVDAWFTGPGLGRRSGRRSRGHCPFQETNQADPAGEPARDSRRERRQ 222

Human   189 KHGHFG----WPGWEMGPPGNWS-------PRPPRAGEARPGP-----------TAESASGPSED 231
            ...|.|    :.......|.|.:       |:.|:|.|....|           .|||.:.|:|.
  Fly   223 ARRHAGVLTQFVEMMTNLPLNTTTATAPAEPQKPKAAEQTESPPQAEPTVTAEKAAESEAKPTEP 287

Human   232 PSVNF-------------------------LKNVGESVAAALSPLGIEV----------DIDVEH 261
            ..||.                         |.|:.:.|.......|||:          .||...
  Fly   288 KKVNTDQSVPRTEDPVTTPRSTQPTTPVINLDNISQIVPPEYMSAGIEILNNFSEMFSKIIDTTE 352

Human   262 GGKRSRLTP---VSPESSSTEEKSSSQPSSCCSD----------PSKPGGNV----EGATQSLAE 309
            ||......|   .|.|:...||:..|...|..|.          ||....||    :.||.|::.
  Fly   353 GGDSGIFAPSTTPSAENKKPEEQGQSSGQSGASSANQSAVPSAAPSANQSNVPSANQSATPSISG 417

Human   310 QMRKIALE--------SEGRPEEQMESDNCSGGDDDW-------------------THLSSKEVD 347
            .:....||        ||...|.:.|.......|.:|                   |:.::...:
  Fly   418 SIPDAQLETEPLNPKPSETTTETEQERRRSDSLDPEWQLIDNAYSANNSNLINLDTTNPTAAPQE 482

Human   348 P-----STGELQSLQMPE--------------------------SEGPSSLDPSQEGPTGLKEAA 381
            |     ..|||....|.|                          |...:|:..|...|...:...
  Fly   483 PVRDFGQLGELLRQHMNEEARVEQASANTQTAQVDTVSTSTSTTSVTTNSVGTSPAAPDDKRTVP 547

Human   382 LYPHLPPEADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKH 436
            :|     ..|..:.:|:..|::||||:||.|||:||::...:|.||||.:..|::
  Fly   548 VY-----HTDESINKSIHAMMAMGFSNEGAWLTQLLESVQGNISAALDVMNVSQN 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SQSTM1	NP_003891.1	Interaction with LCK. /evidence=ECO:0000269\|PubMed:8650207	2..50
		PB1_p62	4..102	CDD:99723	0/2 (0%)
		Interaction with PRKCZ and dimerization. /evidence=ECO:0000250\|UniProtKB:O08623	43..107		2/7 (29%)
		Interaction with PAWR. /evidence=ECO:0000269\|PubMed:11755531	50..80
		Interaction with GABRR3. /evidence=ECO:0000250\|UniProtKB:O08623	122..224		39/158 (25%)
		ZZ_NBR1_like	126..168	CDD:239080	21/42 (50%)
		LIM protein-binding (LB)	170..220		14/94 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..235		12/56 (21%)
		TRAF6-binding	228..233		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..390		35/200 (18%)
		Interaction with NTRK1. /evidence=ECO:0000250\|UniProtKB:O08623	269..440		55/243 (23%)
		MAP1LC3B-binding. /evidence=ECO:0000269\|PubMed:17580304	321..342		5/39 (13%)
		LIR	336..341		2/23 (9%)
		Interaction with KEAP1. /evidence=ECO:0000269\|PubMed:20452972	347..352		1/9 (11%)
		UBA_5	379..440	CDD:318725	21/58 (36%)
ref(2)P	NP_001014491.1	PB1	6..88	CDD:295447
		ZZ	121..165	CDD:278966	21/43 (49%)
		UBA_SQSTM	555..593	CDD:270505	18/37 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143474
Domainoid	1	1.000	44	1.000	Domainoid score	I12348
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7489
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275680at2759
OrthoFinder	1	1.000	-	-		FOG0002104
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15090
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4736
SonicParanoid	1	1.000	-	-		X5995
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.920