DRSC/TRiP Functional Genomics Resources

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Protein Alignment SQSTM1 and nbr1

DIOPT Version :10

Sequence 1:NP_003891.1 Gene:SQSTM1 / 8878 HGNCID:11280 Length:440 Species:Homo sapiens
Sequence 2:NP_001342955.1 Gene:nbr1 / 2541353 PomBaseID:SPBP35G2.11C Length:397 Species:Schizosaccharomyces pombe


Alignment Length:62 Identity:28/62 - (45%)
Similarity:33/62 - (53%) Gaps:7/62 - (11%)


- Green bases have known domain annotations that are detailed below.


Human   122 VHPNVICDGCNG-PVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAF-----PSPFGHLSE 177
            ||.:|.||.|.. |:||.|:.|.||.||||||.|.....|..|:.|..     .||. |||:
pombe   206 VHRSVQCDNCLAHPIVGPRFHCLVCEDYDLCSSCVSHVHHDHHSMLRLTREISASPL-HLSK 266

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SQSTM1NP_003891.1 Interaction with LCK. /evidence=ECO:0000269|PubMed:8650207 2..50
PB1_p62 4..102 CDD:99723
Interaction with PRKCZ and dimerization. /evidence=ECO:0000250|UniProtKB:O08623 43..107
Interaction with PAWR. /evidence=ECO:0000269|PubMed:11755531 50..80
Interaction with GABRR3. /evidence=ECO:0000250|UniProtKB:O08623 122..224 28/62 (45%)
ZZ_NBR1_like 126..168 CDD:239080 21/42 (50%)
LIM protein-binding (LB) 170..220 5/8 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 196..235
TRAF6-binding 228..233
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..390
Interaction with NTRK1. /evidence=ECO:0000250|UniProtKB:O08623 269..440
MAP1LC3B-binding. /evidence=ECO:0000269|PubMed:17580304 321..342
LIR 336..341
Interaction with KEAP1. /evidence=ECO:0000269|PubMed:20452972 347..352
UBA_5 379..440 CDD:318725
nbr1NP_001342955.1 ZnF_ZZ 56..>91 CDD:197633
ZZ_NBR1_like 134..177 CDD:239080
ZZ 210..253 CDD:412288 21/42 (50%)
NBR1_like 275..385 CDD:271343
Blue background indicates that the domain is not in the aligned region.

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