DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SQSTM1 and Sqstm1

DIOPT Version :10

Sequence 1:NP_003891.1 Gene:SQSTM1 / 8878 HGNCID:11280 Length:440 Species:Homo sapiens
Sequence 2:NP_035148.1 Gene:Sqstm1 / 18412 MGIID:107931 Length:442 Species:Mus musculus


Alignment Length:442 Identity:401/442 - (90%)
Similarity:417/442 - (94%) Gaps:2/442 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     1 MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQA 65
            |||.||||||||||:|.|||||||||.||||||||:||||||||||||||||.|||.||||||||
Mouse     1 MASFTVKAYLLGKEEATREIRRFSFCFSPEPEAEAQAAAGPGPCERLLSRVAVLFPTLRPGGFQA 65

Human    66 HYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDG 130
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
Mouse    66 HYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRREHRPPCAQEAPRNMVHPNVICDG 130

Human   131 CNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGW 195
            |||||||||||||||||||||||||||||||.|:||.||:||||||:.|||||||||:|||||||
Mouse   131 CNGPVVGTRYKCSVCPDYDLCSVCEGKGLHREHSKLIFPNPFGHLSDSFSHSRWLRKLKHGHFGW 195

Human   196 PGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLGIEVDIDVE 260
            |||||||||||||||||||:.||.|||||||.|.|||:|||||||||||||||||||||||||||
Mouse   196 PGWEMGPPGNWSPRPPRAGDGRPCPTAESASAPPEDPNVNFLKNVGESVAAALSPLGIEVDIDVE 260

Human   261 HGGKRSRLTPVSPESSS--TEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMRKIALESEGRPE 323
            ||||||||||.:|||||  ||:||::|||||.|:.|||.|..||..|||.|||:||||||.|:||
Mouse   261 HGGKRSRLTPTTPESSSTGTEDKSNTQPSSCSSEVSKPDGAGEGPAQSLTEQMKKIALESVGQPE 325

Human   324 EQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPP 388
            |||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 EQMESGNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPP 390

Human   389 EADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL 440
            ||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 EADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL 442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SQSTM1NP_003891.1 Interaction with LCK. /evidence=ECO:0000269|PubMed:8650207 2..50 42/47 (89%)
PB1_p62 4..102 CDD:99723 90/97 (93%)
Interaction with PRKCZ and dimerization. /evidence=ECO:0000250|UniProtKB:O08623 43..107 61/63 (97%)
Interaction with PAWR. /evidence=ECO:0000269|PubMed:11755531 50..80 27/29 (93%)
Interaction with GABRR3. /evidence=ECO:0000250|UniProtKB:O08623 122..224 91/101 (90%)
ZZ_NBR1_like 126..168 CDD:239080 39/41 (95%)
LIM protein-binding (LB) 170..220 43/49 (88%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 196..235 32/38 (84%)
TRAF6-binding 228..233 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 264..390 107/127 (84%)
Interaction with NTRK1. /evidence=ECO:0000250|UniProtKB:O08623 269..440 152/172 (88%)
MAP1LC3B-binding. /evidence=ECO:0000269|PubMed:17580304 321..342 18/20 (90%)
LIR 336..341 4/4 (100%)
Interaction with KEAP1. /evidence=ECO:0000269|PubMed:20452972 347..352 4/4 (100%)
UBA_5 379..440 CDD:318725 60/60 (100%)
Sqstm1NP_035148.1 Interaction with LCK. /evidence=ECO:0000250|UniProtKB:Q13501 2..50 42/47 (89%)
PB1_p62 5..102 CDD:99723 90/96 (94%)
Interaction with PRKCZ and dimerization. /evidence=ECO:0000250|UniProtKB:O08623 43..107 61/63 (97%)
Interaction with PAWR. /evidence=ECO:0000250|UniProtKB:Q13501 50..80 27/29 (93%)
Interaction with GABRR3. /evidence=ECO:0000250|UniProtKB:O08623 122..224 91/101 (90%)
ZZ_NBR1_like 126..166 CDD:239080 37/39 (95%)
LIM protein-binding. /evidence=ECO:0000250|UniProtKB:Q13501 170..220 43/49 (88%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..234 24/29 (83%)
TRAF6-binding. /evidence=ECO:0000250|UniProtKB:Q13501 228..233 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..308 30/45 (67%)
Interaction with NTRK1. /evidence=ECO:0000250|UniProtKB:O08623 269..442 152/172 (88%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 321..386 61/64 (95%)
MAP1LC3B-binding. /evidence=ECO:0000250|UniProtKB:Q13501 323..344 18/20 (90%)
LIR. /evidence=ECO:0000269|PubMed:33397898 338..343 4/4 (100%)
Interaction with KEAP1. /evidence=ECO:0000269|PubMed:20173742, ECO:0000269|PubMed:20421418 349..354 4/4 (100%)
UBA_5 381..442 CDD:318725 60/60 (100%)

Return to query results.
Submit another query.