Protein Alignment SQSTM1 and gldi-4

DIOPT Version :10

• Sequence 1: NP_003891.1
• Gene: SQSTM1 / 8878
• HGNCID: 11280
• Length: 440
• Species: Homo sapiens
• Sequence 2: NP_501086.1
• Gene: gldi-4 / 177467
• WormBaseID: WBGene00015552
• Length: 498
• Species: Caenorhabditis elegans
• Alignment Length: 76
• Identity: 24/76 - (31%)
• Similarity: 40/76 - (52%)
• Gaps: 8/76 - (10%)

Human   100 KEKKECRRDHRPPCAQEAPRNM-----VHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGL 159
            |:..|.:.:::  |.::..:|.     || ...||.|...::|.|:||::|.:||||..||..|:
 Worm   166 KDISEMKLENQ--CRKKEDKNSFKNKEVH-EASCDKCQDLIIGHRFKCAICYNYDLCETCEAAGV 227

Human   160 HRGHTKLAFPS 170
            |..|..:...|
 Worm   228 HAQHALIRLVS 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SQSTM1	NP_003891.1	Interaction with LCK. /evidence=ECO:0000269|PubMed:8650207	2..50
		PB1_p62	4..102	CDD:99723	1/1 (100%)
		Interaction with PRKCZ and dimerization. /evidence=ECO:0000250|UniProtKB:O08623	43..107		2/6 (33%)
		Interaction with PAWR. /evidence=ECO:0000269|PubMed:11755531	50..80
		Interaction with GABRR3. /evidence=ECO:0000250|UniProtKB:O08623	122..224		20/49 (41%)
		ZZ_NBR1_like	126..168	CDD:239080	17/41 (41%)
		LIM protein-binding (LB)	170..220		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..235
		TRAF6-binding	228..233
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..390
		Interaction with NTRK1. /evidence=ECO:0000250|UniProtKB:O08623	269..440
		MAP1LC3B-binding. /evidence=ECO:0000269|PubMed:17580304	321..342
		LIR	336..341
		Interaction with KEAP1. /evidence=ECO:0000269|PubMed:20452972	347..352
		UBA_5	379..440	CDD:318725
gldi-4	NP_501086.1	ZZ_NBR1_like	194..236	CDD:239080	17/41 (41%)