Protein Alignment SQSTM1 and Sqstm1

DIOPT Version :10

• Sequence 1: NP_003891.1
• Gene: SQSTM1 / 8878
• HGNCID: 11280
• Length: 440
• Species: Homo sapiens
• Sequence 2: NP_787037.2
• Gene: Sqstm1 / 113894
• RGDID: 69287
• Length: 439
• Species: Rattus norvegicus
• Alignment Length: 442
• Identity: 402/442 - (90%)
• Similarity: 416/442 - (94%)
• Gaps: 5/442 - (1%)

Human     1 MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQA 65
            ||||||||||||||:|||||||||||.||||  |||||||||||||||||||.||||||||||||
  Rat     1 MASLTVKAYLLGKEEAAREIRRFSFCFSPEP--EAEAAAGPGPCERLLSRVAVLFPALRPGGFQA 63

Human    66 HYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDG 130
            ||||||||||||||||||||||||||||||||||||||||||:||||||||| |:||||||||||
  Rat    64 HYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRREHRPPCAQEA-RSMVHPNVICDG 127

Human   131 CNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGW 195
            |||||||||||||||||||||||||||||||.|:||.||:||||||:.|||||||||:|||||||
  Rat   128 CNGPVVGTRYKCSVCPDYDLCSVCEGKGLHREHSKLIFPNPFGHLSDSFSHSRWLRKLKHGHFGW 192

Human   196 PGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLGIEVDIDVE 260
            |||||||||||||||||||:.||.|||||||.|||||:|||||||||||||||||||||||||||
  Rat   193 PGWEMGPPGNWSPRPPRAGDGRPCPTAESASAPSEDPNVNFLKNVGESVAAALSPLGIEVDIDVE 257

Human   261 HGGKRSRLTPVSPESSS--TEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMRKIALESEGRPE 323
            ||||||||||.|.||||  ||:||.:|||||.|:.|||.|..||..|||.|||:||||||.|:||
  Rat   258 HGGKRSRLTPTSAESSSTGTEDKSGTQPSSCSSEVSKPDGAGEGPAQSLTEQMKKIALESVGQPE 322

Human   324 EQMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPP 388
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   323 ELMESDNCSGGDDDWTHLSSKEVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPP 387

Human   389 EADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL 440
            ||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   388 EADPRLIESLSQMLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SQSTM1	NP_003891.1	Interaction with LCK. /evidence=ECO:0000269|PubMed:8650207	2..50		43/47 (91%)
		PB1_p62	4..102	CDD:99723	92/97 (95%)
		Interaction with PRKCZ and dimerization. /evidence=ECO:0000250|UniProtKB:O08623	43..107		62/63 (98%)
		Interaction with PAWR. /evidence=ECO:0000269|PubMed:11755531	50..80		28/29 (97%)
		Interaction with GABRR3. /evidence=ECO:0000250|UniProtKB:O08623	122..224		91/101 (90%)
		ZZ_NBR1_like	126..168	CDD:239080	39/41 (95%)
		LIM protein-binding (LB)	170..220		43/49 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..235		33/38 (87%)
		TRAF6-binding	228..233		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..390		107/127 (84%)
		Interaction with NTRK1. /evidence=ECO:0000250|UniProtKB:O08623	269..440		152/172 (88%)
		MAP1LC3B-binding. /evidence=ECO:0000269|PubMed:17580304	321..342		18/20 (90%)
		LIR	336..341		4/4 (100%)
		Interaction with KEAP1. /evidence=ECO:0000269|PubMed:20452972	347..352		4/4 (100%)
		UBA_5	379..440	CDD:318725	60/60 (100%)
Sqstm1	NP_787037.2	Interaction with LCK. /evidence=ECO:0000250|UniProtKB:Q13501	2..48		43/47 (91%)
		PB1_p62	4..100	CDD:99723	92/97 (95%)
		Interaction with PRKCZ and dimerization. /evidence=ECO:0000269|PubMed:10477520, ECO:0000269|PubMed:12431995	41..105		62/63 (98%)
		Interaction with PAWR. /evidence=ECO:0000250|UniProtKB:Q13501	48..78		28/29 (97%)
		Interaction with GABRR3. /evidence=ECO:0000269|PubMed:12431995	119..221		91/101 (90%)
		ZZ_NBR1_like	123..163	CDD:239080	37/39 (95%)
		LIM protein-binding. /evidence=ECO:0000250|UniProtKB:Q13501	167..217		43/49 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..231		25/29 (86%)
		TRAF6-binding. /evidence=ECO:0000250	225..230		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..389		109/129 (84%)
		Interaction with NTRK1. /evidence=ECO:0000269|PubMed:11244088	266..439		152/172 (88%)
		MAP1LC3B-binding. /evidence=ECO:0000250|UniProtKB:Q13501	320..341		18/20 (90%)
		LIR	335..340		4/4 (100%)
		Interaction with KEAP1. /evidence=ECO:0000250|UniProtKB:Q64337	346..351		4/4 (100%)
		UBA_5	378..439	CDD:318725	60/60 (100%)