DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VNN2 and CG32751

DIOPT Version :9

Sequence 1:	NP_004656.3	Gene:	VNN2 / 8875	HGNCID:	12706	Length:	520	Species:	Homo sapiens
Sequence 2:	NP_001284927.1	Gene:	CG32751 / 318189	FlyBaseID:	FBgn0052751	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	146/507 - (28%)
Similarity:	215/507 - (42%)	Gaps:	86/507 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    55 NENIDILETAIKQAAEQGAR---IIVTPEDALYGWKFTRETVFPYLEDIPDPQVNWIPC-QDPHR 115
            ||..|.|...::....|.|.   |||.||..|   .....|.|     :|:|:....|| .||:.
  Fly    44 NELSDNLAGYLEIIQSQNATSTDIIVFPESTL---NSAGSTTF-----VPNPEDQINPCLSDPNA 100

Human   116 FGHTPVQARLSCLAKDNSIYVLANLGDKKPCNS--RDS-TCPPNGYFQYNTNVVYNTEGKLVARY 177
            ..:......|||.|::.|.|::.||.:|:.|..  .|: .|..||...:|||||::.:|.:|:||
  Fly   101 TYYEEFLVTLSCAARNASKYIVINLTEKQKCEDIPEDTRPCASNGLNVFNTNVVFDRQGVVVSRY 165

Human   178 HKYHLYSEPQFNVPEKPELVTFNTAFG-RFGIFTCFDIFFYDPGVTLVKDFHVDTILFPTAWMNV 241
            .|.|||.||: |....|||.||.|.|| .||.|.||||.||.|...|:.:..:...::|..|.:.
  Fly   166 RKVHLYGEPK-NSTFLPELSTFETDFGVTFGHFICFDILFYTPAHQLIVEQGITDFVYPAMWFSQ 229

Human   242 LPLLT--------AIEFHSAWAMGMGVNLLVANTHHVSLNMTGSGIYAPNGPKVYHYDMKTELGK 298
            ||.||        |::....|:....||||.|......:..:|||||......:... |:.|.|:
  Fly   230 LPFLTVNGIFSSKAVQIQLGWSYANNVNLLAAGASDPIVGNSGSGIYHGRSGSLRSV-MRQESGE 293

Human   299 LLLSEVDSHPLSSLAYPTAVNWNAYATTIKPFPVQKNTFRGF-ISRDGF-NFT--ELFENAGNL- 358
                       .|:.......:.|.....:....|..|...| |.||.. |||  ||..:||.:
  Fly   294 -----------RSIYVARVPKYRAKRRMKRDLKRQVATSSSFNIKRDYLENFTSEELKIDAGKIG 347

Human   359 ----TVCQKELCCH--LSYRMLQKEENEV----YVLGAFTGLHGRRRRE--YWQVCTLLKCKTTN 411
                .:|....|||  |::|.|.|.....    |.:|.:.|....:|.:  |.:.|.:..|...:
  Fly   348 NLSQNLCHGGFCCHFDLAWRSLGKPSRNTSHYSYRVGIYEGWRNEKRLDVNYIRNCGVFTCSGNS 412

Human   412 LTTCG-------RPVETASTRFEMFSLSGTF--GTEY-VFPEVLLTE-IHLSPGKFE-----VLK 460
            :..||       ||:.|    |....:..|:  ..|: :||:.||.. :.|.|.:||     :.:
  Fly   413 IDDCGQLLPDIQRPLVT----FTHVEIRVTYPQSREFLLFPDTLLDNLLPLEPKQFEWSQKRISE 473

Human   461 DGRLV----NKNGSSGPILTVSLFGRWYTKDSLYS--------SCGTSNSAI 500
            :...|    .|:.....:||..::|.:|..:..:.        .||..|..|
  Fly   474 ESHQVRFALRKSLEVKHLLTFGIYGNYYNNECTFGVGTAEEQLECGYKNPKI 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VNN2	NP_004656.3	biotinidase_like	26..329	CDD:143591	92/289 (32%)
VNN2	NP_004656.3	Vanin_C	344..487	CDD:408788	45/178 (25%)
CG32751	NP_001284927.1	biotinidase_like	33..329	CDD:143591	96/305 (31%)
CG32751	NP_001284927.1	Vanin_C	324..503	CDD:408788	48/182 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157430
Domainoid	1	1.000	106	1.000	Domainoid score	I6567
eggNOG	1	0.900	-	-		E1_COG0388
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4209
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276751at2759
OrthoFinder	1	1.000	-	-		FOG0001380
OrthoInspector	1	1.000	-	-		mtm8613
orthoMCL	1	0.900	-	-		OOG6_103493
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X969
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.660