DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ARHGEF7 and PIN3

DIOPT Version :9

Sequence 1:	NP_001340975.1	Gene:	ARHGEF7 / 8874	HGNCID:	15607	Length:	862	Species:	Homo sapiens
Sequence 2:	NP_015480.1	Gene:	PIN3 / 856277	SGDID:	S000006358	Length:	215	Species:	Saccharomyces cerevisiae

Alignment Length:	104	Identity:	31/104 - (29%)
Similarity:	43/104 - (41%)	Gaps:	17/104 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   168 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV-SPKS 231
            |.|.:.|....:.:|....||.:.:.......|::|:.|||||.||:|||       ||. |..:
Yeast    59 VEALYQFDPQQDGDLGLKPGDKVQLLEKLSPEWYKGSCNGRTGIFPANYV-------KPAFSGSN 116

Human   232 GTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQ 270
            |....||.        ..|....||.| .|:|..:...|
Yeast   117 GPSNLPPP--------PQYKAQELQQI-PTQNSAASSYQ 146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGEF7	NP_001340975.1	CH	21..107	CDD:237981
		RhoGEF67_u1	117..163	CDD:318756
		SH3_betaPIX	167..220	CDD:212994	18/51 (35%)
		RhoGEF	251..428	CDD:238091	6/20 (30%)
		PH_Cool_Pix	459..557	CDD:269932
		Atrophin-1	<562..>643	CDD:331285
		RhoGEF67_u2	613..711	CDD:318755
		betaPIX_CC	773..859	CDD:318676
PIN3	NP_015480.1	SH3	58..110	CDD:418401	18/57 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910