Protein Alignment ARHGEF7 and trio

DIOPT Version :10

• Sequence 1: XP_047286678.1
• Gene: ARHGEF7 / 8874
• HGNCID: 15607
• Length: 874
• Species: Homo sapiens
• Sequence 2: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Alignment Length: 1086
• Identity: 215/1086 - (19%)
• Similarity: 385/1086 - (35%)
• Gaps: 312/1086 - (28%)

Human     3 SAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESEC- 66
            |.:.|..|...:...|...|.::....|    .|....:|.:|:     ::|:.|  .|.:..|
  Fly   978 SDDVTKKWQQLVTYAEERHKLVTASINF----YKTAEQVCSVLD-----SLEREY--KREDDWCD 1031

Human    67 --------------LSNIRE----FLRGCGASLR-LETF-----DANDLYQ------GQNFNKVL 101
                          :|..:|    ||:.|..:.| .|||     .:...||      |...:|:.
  Fly  1032 GGGGSDKAQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLD 1096

Human   102 SSLVTLNKVTADIGLGSDSV--C------ARPSSHRIKSFDSLGSQSLHTR----------TSKL 148
            ..|...|:|.....|...|:  |      .|.:...|:...:.|...|.:|          |..|
  Fly  1097 KLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGL 1161

Human   149 FQ--GQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGW 211
            .:  .::||.........:|:::.        .|.| ..||.. |.:.:::   |..:::.|...
  Fly  1162 LKEHNEFRSTAKETRERVKLLIQL--------ADSL-VEKGHA-HASDIKQ---WVASVDQRYKD 1213

Human   212 FPS---NYVREVKAS--------------EKPVSPKSGTLKSPP--------KGFDTTAINKS-- 249
            |.:   :|..:::.|              ...:|..||...|.|        ...:...||:.
  Fly  1214 FSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSNKENKEINEEKR 1278

Human   250 ----YYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANI---SYLMGNLEEICSF-QQ 306
                ....::..:::||..|..:|.|.:..:|...:..:.:.||.|   ..:.||::||..| |:
  Fly  1279 KSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQK 1343

Human   307 MLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHS----EELGEFMET 367
            :.::.||:...:||   .||.||:....:. .:|:.||.|.|::.|:|.:|.    |||...:|
  Fly  1344 IFLRELEKYETMPE---DVGHCFVTWASKF-DMYVHYCKNKPTSNNLLVQHGGSFFEELQRRLE- 1403

Human   368 KGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQE--- 429
              ...|    |...|.||..|:.||..|||:|....|:.|   .:|::.:....|:..:..:
  Fly  1404 --VDHP----LPAYLIKPVQRITKYQLLLKDLLSCCEESH---GEIKEGLEVMLNVPKKANDAMH 1459

Human   430 ----------VRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFP 484
                      |.|..|:.||   :|.:.|:...|...|                  .||.:.||
  Fly  1460 LSLLENCDVSVDKLGEVVLQ---DAFQAWDTKQIIRKG------------------RERRVFLF- 1502

Human   485 NVLLMLSASPRMSGFI---YQGKLPTTGMTITK-LEDSENHRNAFEISGSMIE--RILVSCNNQQ 543
            .:.|:.:...:.|..:   ::.||.||.|.||: :|..|.....:.....|:.  ||::...:.:
  Fly  1503 ELYLLFAKEVKESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLE 1567

Human   544 DLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSK-------PAPLTPAYHT 601
            ..|.||:.|::..:.|.....::        |||..|    :||:.|.       ...||...|.
  Fly  1568 TKQIWVKKLREVMQETCFSGTSL--------TLPKSP----AKHSGSSQRSSRDLDEQLTENDHD 1620

Human   602 LPHPSHHGTPHTT----------------------------INWGP----LEPPKTPKP------ 628
            ....:..|:.:||                            ::.|.    :|||...:|
  Fly  1621 RCSLASFGSGNTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVR 1685

Human   629 --------------WSLSCLRPAP-------PLRPSAALCYKEVRS--LDHSNSQMTD-LSKSPK 669
                          ..:|.|:|.|       ....:||......:|  .|.||....| ||.|.|
  Fly  1686 LNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTK 1750

Human   670 -----------------TMKKLLPKRKP-ERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAK 716
                             |.|.  |..|| .:|||::...:.:..|....:.|..:...:..|...
  Fly  1751 RRGFSGRNWLPLMNRKGTDKP--PSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQPGASPATVLP 1813

Human   717 TRQTLNSTWQ---------------GTDL-------MHNHVLADDD----QPSLDSLGRRSSLSR 755
            :.|..:||..               |.:|       ...|::|:..    :.:.:|.|..:|..:
  Fly  1814 SSQFPSSTQHPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGPPAFAKDAKESSGNMASPGK 1878

Human   756 LEPSDLSEDSDYDSIWTAHSYRMGSTSRSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVD 820
            ::.:.|||..:           :..|:..:.||..:|    :....||...:||.....:.: .:
  Fly  1879 MDGNPLSEIEE-----------IVKTTTEQHESNSRV----DGGGGVENASTNGHGRSHDNN-DE 1927

Human   821 TVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMND 866
            :..|:.|:...|::......:.:..|:...:||.::|...:..:|:
  Fly  1928 SHTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINN 1973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGEF7	XP_047286678.1	CH_betaPIX	3..115	CDD:409115	29/142 (20%)
		RhoGEF67_u1	117..163	CDD:465201	11/65 (17%)
		SH3_betaPIX	167..220	CDD:212994	9/55 (16%)
		RhoGEF	251..428	CDD:238091	51/184 (28%)
		PH_Cool_Pix	459..557	CDD:269932	22/103 (21%)
		PHA03247	<564..647	CDD:223021	24/148 (16%)
		RhoGEF67_u2	617..719	CDD:465200	31/153 (20%)
		betaPIX_CC	789..873	CDD:465158	13/78 (17%)
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103	4/18 (22%)
		SPEC	897..1119	CDD:238103	31/151 (21%)
		SPEC	1125..1226	CDD:197544	19/113 (17%)
		RhoGEF	1287..1455	CDD:459876	51/181 (28%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	31/143 (22%)
		SH3_Kalirin_1	1643..1707	CDD:212786	7/63 (11%)
		RhoGEF	1945..2121	CDD:459876	5/29 (17%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061