DRSC/TRiP Functional Genomics Resources

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Protein Alignment ARHGEF7 and rng2

DIOPT Version :9

Sequence 1:NP_001340975.1 Gene:ARHGEF7 / 8874 HGNCID:15607 Length:862 Species:Homo sapiens
Sequence 2:NP_593860.1 Gene:rng2 / 2543129 PomBaseID:SPAC4F8.13c Length:1489 Species:Schizosaccharomyces pombe


Alignment Length:1226 Identity:218/1226 - (17%)
Similarity:386/1226 - (31%) Gaps:459/1226 - (37%)


- Green bases have known domain annotations that are detailed below.


Human    17 LESPKKTISD-------PEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSE---SECLSNIR 71
            ::..||.|.:       |....:.||::||||..|:::..|..:.|::.....:   |:.::...
pombe    44 VDEAKKWIEECLGTDLGPTSTFEQSLRNGVVLALLVQKFQPDKLIKIFYSNELQFRHSDNINKFL 108

Human    72 EFLRGCGASLRLETFDANDLYQGQNFNKVL----------------------------------- 101
            :|:.|.|.. .:..|:..|:|:|:|..||:                                   
pombe   109 DFIHGIGLP-EIFHFELTDIYEGKNLPKVIYCIHALSYFLSMQDLAPPLIKSDENLSFTDEDVSI 172

Human   102 -------SSLVTLN--KVTADIGLGSDSVCAR-------PSSHRIKSFDSLGSQS---------- 140
                   |:::..|  .::||..|.:..|.:|       |...|.::.:|..|.|          
pombe   173 IVRRLRQSNVILPNFKALSADFMLRASPVSSRTPSPTRFPKHARFQTLNSSDSASIYSSPYTSPT 237

Human   141 ----------------LHTRT--------------------------SKLFQG------------ 151
                            :|.||                          ...||.            
pombe   238 LEFSKKDASARSDILKMHRRTKSATPSLEQFNEPYKQTLPSHSIEFEDSFFQPPSQKGHMQRSFL 302

Human   152 -------------------------------------------QYRSLDM----TDNSNN----Q 165
                                                       :.|.:||    .:.|::    |
pombe   303 TTFSAPTRRREALFSTTSGLSQRSPVDEKIVNAIQACGRGVLVRLRLVDMLQSLVEQSSSVVLLQ 367

Human   166 LVVRA-----KFNFQQTNEDEL--------SFSKGDVIH-----VTRVEEGGWWEGTLNG--RTG 210
            .|:|.     .:..::...|||        |.|:..:|.     |...||......||..  |.|
pombe   368 AVIRGYISRNTYRIRKKAYDELVNWVTSIQSISRAYLIRAQYRKVVLQEEATKSIQTLQSIIRGG 432

Human   211 WFPSNYVREVKASEKPVSPKSGTLKSPPKGFDT--TAIN--KSYYNVV-----LQNILET---EN 263
            ::...|...::..:. .:|....::|...||.|  ..:|  .:.||.:     :|:||..   .|
pombe   433 FYRRKYHSLIERLDL-FTPSFVLIQSSALGFLTRHAIVNMLDNLYNYIPLFNRMQSILRANMFRN 496

Human   264 EYSKELQTVLS------TYLRPLQTSEKLSSANISYLMGNLEEICSFQQM------------LVQ 310
            |:|..|.:|.|      :..:.....:.::..|.| |:|.|:.....|.:            .::
pombe   497 EWSNFLDSVQSFPVSFHSICKGRLIRDSINRLNGS-LLGELDNFIKLQNLSRGFMIRRAFKEKLE 560

Human   311 SLEECTKLPEAQQRVGGCFLNLMPQMKTLY-------------------------LTYCANH--- 347
            .|:..|....|.|.:...|| |...::::|                         :.||.::   
pombe   561 KLKASTSSFIALQAIVRAFL-LRKNLESIYDSFQKSHLSVIKAQSLYRGFITRTKIDYCNDYLLK 624

Human   348 --------PSAVNVL-----TEHSE-ELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKE 398
                    .|||..:     ..::| :|..|:..        :||...|.:.::..:|:...|:.
pombe   625 RLPDIVFMQSAVRAILLRDDVNYTEVQLDSFIPE--------IVLLQSLIRGYLSRNKFSRKLQN 681

Human   399 LERHMED------YHTDRQD--IQKSMAAFKNLSAQ----------------------------- 426
            ..::||:      ....||:  ..:.:|..||....                             
pombe   682 FHKNMENPIVAKSIFRGRQEGLAYRELATAKNPPVMTVKNFVHLLDDTNFDFEEEVLLEKMRKEI 746

Human   427 CQEVRKRKELELQI------LTEAIRNWEG-DDIKTLGN--------VTYMSQVLIQCAGSEEKN 476
            .|:||..:|:|:.|      :...::|... ||:....|        ..|:....:........:
pombe   747 VQQVRDNEEIEVHINELDVKIALLVKNKISLDDVLKHHNKYKFGKQSTEYLKINTLSMKSLNNSS 811

Human   477 ERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDS-----------ENHRN-----AF 525
            .::|.|:.....:|..:.......:|. |.|.|.:..|:..:           .|.|.     .|
pombe   812 RKFLELYQCFFYVLQTNEMYLANYFQA-LKTEGTSSVKIRHAVYLVLQIFGHGSNRREEVLLLRF 875

Human   526 EISGSMIERILVSCNNQQDL--QEWVEHL--------QKQTKV--TSVGNPTIKPHSVPSHTLPS 578
            ......:|..||  |:.|||  .:.|..|        .::.|:  |.:|.              .
pombe   876 ISQVIKLEAALV--NSSQDLLSDDCVWKLLFTGYRGDVREVKLWKTILGR--------------I 924

Human   579 HPVTPSSKHADSKPAPLTPAYHTLPH-PSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRP 642
            |.|..:..|.|.:..|||......|. .|...:|..|::.....||..    :|...|    ||.
pombe   925 HKVLVADNHLDFEINPLTLFKSFNPEVASQTDSPKLTLSLAMQHPPTR----NLYVSR----LRE 981

Human   643 SAALC--YKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKT 705
            ...||  :...|||:.:.:...|.....:.|.|    ..|...||.:|  :|..||..:...|..
pombe   982 LRKLCQSFLVALSKNIENIPYALCYTAAQLKNS----LQRYFPAAHKE--EIFGVIGKFVYWAYV 1040

Human   706 RQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRS--SLSRLEPSDLSEDSDYDSIWTAHSYRMGS 768
            ...|.|.       .|..|.|.   |:.:|.|::  :||    |.|||   ..||.:..|.::| 
pombe  1041 APVLVSP-------DNFKLVDG---SITALQRKNLYTLS----SILSE---IFSIESCDSKQLG- 1087

Human   769 TSRSRKESAPQVLLPEEEKIIVEETKSNGQTVIEE----------------KSLVDT----VYAL 813
                       ...|..|  .:|.:|.:...::|.                :.||:|    :|..
pombe  1088 -----------FFRPLSE--FIEVSKQDTMLMLERLVDVVDPEVYFEFDAFEDLVNTKRPVIYMK 1139

Human   814 KDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNM-------NDPAWDETNL 862
            :|::..:......:..|:     |..|:...:|.|:.::       ||...|||::
pombe  1140 RDDILGIYSSIAYVIDSI-----APPDVNDPLRAVVNSLGPVSEQDNDFVQDETDV 1190

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ARHGEF7NP_001340975.1 CH 21..107 CDD:237981 25/137 (18%)
RhoGEF67_u1 117..163 CDD:318756 15/163 (9%)
SH3_betaPIX 167..220 CDD:212994 16/72 (22%)
RhoGEF 251..428 CDD:238091 45/281 (16%)
PH_Cool_Pix 459..557 CDD:269932 21/123 (17%)
Atrophin-1 <562..>643 CDD:331285 18/81 (22%)
RhoGEF67_u2 613..711 CDD:318755 24/99 (24%)
betaPIX_CC 773..859 CDD:318676 17/112 (15%)
rng2NP_593860.1 IQG1 1..1489 CDD:227586 218/1226 (18%)
CH 42..145 CDD:237981 24/101 (24%)
RasGAP_IQGAP_related 846..1217 CDD:213345 87/411 (21%)
RasGAP_C 1274..1410 CDD:281787
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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