Protein Alignment SYNJ2 and Synj2

DIOPT Version :10

• Sequence 1: NP_003889.1
• Gene: SYNJ2 / 8871
• HGNCID: 11504
• Length: 1496
• Species: Homo sapiens
• Sequence 2: NP_001106842.1
• Gene: Synj2 / 84018
• RGDID: 69436
• Length: 1496
• Species: Rattus norvegicus
• Alignment Length: 1515
• Identity: 1263/1515 - (83%)
• Similarity: 1327/1515 - (87%)
• Gaps: 45/1515 - (2%)

Human     1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDAYGCLG 65
            ||||||||||.||...|..|||||||||.||||||||.||||||||||||||.|||.||||||||
  Rat     1 MALSKGLRLLARLDPTGPSSVLLEARGRGDCLLFEAGAVATLAPEEKEVIKGLYGKPTDAYGCLG 65

Human    66 ELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIALKKILSSGVFY 130
            ||.|||||..|||||||||||||||||||||||||.|:|||||||||||:||.||||||||||||
  Rat    66 ELSLKSGGVPLSFLVLVTGCTSVGRIPDAEIYKITGTEFYPLQEEAKEEDRLPALKKILSSGVFY 130

Human   131 FSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDWLLKIICGVVTIRTVY 195
            |:|||||:.||||:|.||||||.||||.|||||||||||||||||:|.|||||:|||||||||||
  Rat   131 FAWPNDGACFDLTIRAQKQGDDCSEWGTSFFWNQLLHVPLRQHQVNCHDWLLKVICGVVTIRTVY 195

Human   196 ASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIRGSVPLFWE 260
            ||||||||||:||:||||.|.||.||||||||||||||||||.||||||||||||||||||||||
  Rat   196 ASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQAIYMDDGVSSFVQIRGSVPLFWE 260

Human   261 QPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASC 325
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
  Rat   261 QPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASC 325

Human   326 HAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSPRFQKGTLRMNCLDCL 390
            ||||||||||||||||||.||||||.||||||||||:||.||.||||||||||||||||||||||
  Rat   326 HAGDTPMINFDFHQFAKGRKLEKLENLLRPQLKLHWDDFGVFAKGENVSPRFQKGTLRMNCLDCL 390

Human   391 DRTNTVQSFIALEVLHLQLKTLGLSSKPIVDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVG 455
            |||||||.|||||||||||::|||:||||.||||||||||||||||.||||||||||||||||||
  Rat   391 DRTNTVQCFIALEVLHLQLESLGLNSKPITDRFVESFKAMWSLNGHGLSKVFTGSRALEGKAKVG 455

Human   456 KLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALL------------ 508
            |||||||||||||||||||||||||||||||||||.||..|||.||||:||||
  Rat   456 KLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTALLGLGSNKQNSLSG 520

Human   509 -----VTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGA 568
                 .|||||||||||||||||||||:|||||||||||||||||:|.|.||||||||:||||||
  Rat   521 MLDGKATPRILKAMTERQSEFTNFKRIQIAMGTWNVNGGKQFRSNLLGTTELTDWLLDAPQLSGA 585

Human   569 TDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVC 633
            .|||||..|||||||||||||||||||||||||||:|||||||||||||||||||||||||||||
  Rat   586 VDSQDDGGPADIFAVGFEEMVELSAGNIVNASTTNRKMWGEQLQKAISRSHRYILLTSAQLVGVC 650

Human   634 LYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNE 698
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   651 LYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNE 715

Human   699 DYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSG 763
            ||:|||.||.||.|||:|||||||||||||||||||||||||||||||||||:||||||||||||
  Rat   716 DYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLMEFDQLQLQKSSG 780

Human   764 KIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLD 828
            |||||||||.|||||||||||||||||||||||||||||||||||||||:|||||||||||||||
  Rat   781 KIFKDFHEGTINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPYDKTAGELNLLDSDLD 845

Human   829 VDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVV 893
            .|..:|||||||.|:||||||||||||||||||||||||||||||||||||||||.||||||||:
  Rat   846 GDANIRHTWSPGTLKYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSVQGPLDATVI 910

Human   894 VNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKG 958
            ||||||||||:||||||||||||||||:||||:||||||||||||||||||||||||||||||||
  Rat   911 VNLQSPTLEERNEFPEDLRTELMQTLGNYGTIILVRINQGQMLVTFADSHSALSVLDVDGMKVKG 975

Human   959 RAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDEDYLV 1023
            |||||||||||||:|||||:|||||||||||||||||||||||||||||||||||:||||||||.
  Rat   976 RAVKIRPKTKDWLEGLREELIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDVLEDDEDYLA 1040

Human  1024 DEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRELEAVGEFR 1088
            |||.||.||||||||||.||.  .:|..|.||||||.||||||||||||||:.||.|||..|.||
  Rat  1041 DEFGQPVVSDSELGGDDSSDT--MSASTPASKSPALAKKKQHPTYKDDADLMTLKLELEVAGNFR 1103

Human  1089 HRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTARLLPGAPQQPP 1153
            |||||||||||||||||.||||||||||||||||||||||||||||||||||||:||||||||||
  Rat  1104 HRSPSRSLSVPNRPRPPHPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTAKLLPGAPQQPP 1168

Human  1154 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTP----G 1214
            |||||||||||||||||||||||||||||||||.||..|.|              |..||    |
  Rat  1169 KARTGISKPYNVKQIKTTNAQEAEAAIRCLLEAGGGVPESA--------------PGATPLRNQG 1219

Human  1215 AAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVT 1279
            ::|||....||:|||||.||||.:|||||||||||:..|||.|||.||||:...|.::|.||.:|
  Rat  1220 SSKPEASLGPPVLPRRPVPRVPTMKKPTLRRTGKPMLSEEQCEQQPVHFTMASQEMNLETPPPIT 1284

Human  1280 APRVPPVPKPRTFQPGKAAE-RPSHRKPASDEAPPGAGA---SVPPPLEAPPLVPKVPPRRKKSA 1340
            || :||||||||||||:..| |||..||..|:|||..||   |.|...|||.|.|||||||||||
  Rat  1285 AP-IPPVPKPRTFQPGRGVERRPSGGKPEPDDAPPVTGAVELSSPEAPEAPSLAPKVPPRRKKSA 1348

Human  1341 PAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAA 1405
            ||||||||||||||||||||.:|| |||...|....::|| ..|.||||.||::||.:..:||||
  Rat  1349 PAAFHLQVLQSNSQLLQGLTCSSS-SPSPPKPDTPLLYPQ-MALGTSSAISPETDGPRVTEPEAA 1411

Human  1406 PLLGDYQDPFWNLLHHPKLL-NNTWLSKSSDPLDSGTRSPKRDPIDPVSAGASAAKAELPPDHEH 1469
            ...|||.||||:|||||||| |||||||||:|||.|:|:|:|...|.....||..:..|||||..
  Rat  1412 SFHGDYPDPFWSLLHHPKLLNNNTWLSKSSEPLDLGSRTPERTHTDSAQVNASVVERGLPPDHGG 1476

Human  1470 KTLGHWVTISDQEKRTALQV 1489
            |...||:..|:::|||.|.|
  Rat  1477 KDFSHWMAASNKDKRTTLGV 1496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SYNJ2	NP_003889.1	COG5329	13..485	CDD:227637	427/471 (91%)
		EEP	530..861	CDD:469791	307/330 (93%)
		DUF1866	872..1008	CDD:286093	128/135 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1027..1073		33/45 (73%)
		PHA03247	<1035..1407	CDD:223021	266/379 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1085..1166		77/80 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1190..1405		128/222 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1427..1473		24/45 (53%)
Synj2	NP_001106842.1	COG5329	28..485	CDD:227637	417/456 (91%)
		EEP	547..878	CDD:469791	307/330 (93%)
		DUF1866	889..1025	CDD:286093	128/135 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1047..1083		26/37 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1100..1149		46/48 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1205..1357		96/166 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1393..1413		11/19 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1442..1461		8/18 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1468..1496		13/27 (48%)