DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SYNJ2 and Synj

DIOPT Version :9

Sequence 1:	NP_003889.1	Gene:	SYNJ2 / 8871	HGNCID:	11504	Length:	1496	Species:	Homo sapiens
Sequence 2:	NP_001246454.1	Gene:	Synj / 37517	FlyBaseID:	FBgn0034691	Length:	1218	Species:	Drosophila melanogaster

Alignment Length:	1381	Identity:	542/1381 - (39%)
Similarity:	757/1381 - (54%)	Gaps:	212/1381 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     1 MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDAYGCLG 65
            ||:||.:|:|.:..|....|||||.|.:.|.:|||:..||.|..:|.:||:.||.|:.|||||||
  Fly     1 MAMSKVIRVLEKSIAPSPHSVLLEHRNKSDSILFESHAVALLTQQETDVIRKQYTKVCDAYGCLG 65

Human    66 ELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIALKKILSSGVFY 130
            .|:|.:|.:::.||||||||.|:|:|.|.||::||.|.|..||..|..|:::..::|:|:||.||
  Fly    66 ALQLNAGESTVLFLVLVTGCVSMGKIGDIEIFRITQTTFVSLQNAAPNEDKISEVRKLLNSGTFY 130

Human   131 FSWPNDGS--------RFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDWLLKIICG 187
            |:..|..:        |||:|:..|:: ..:.|..|.||||:::|:.|.:..:.|..|||:.:||
  Fly   131 FAHTNASASASGASSYRFDITLCAQRR-QQTQETDNRFFWNRMMHIHLMRFGIDCQSWLLQAMCG 194

Human   188 VVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIYMDDGVSSFVQIR 252
            .|.:||||...|||:|.::||:||||.||||:.||.||:|:|:|||||||:||:|..|:|:||.|
  Fly   195 SVEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTR 259

Human   253 GSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNLL-----GSRGGEEV 312
            |||||||||||:|||||.::|.||.|.:|.||||||.:::::||.|.|||||     ||:.||.:
  Fly   260 GSVPLFWEQPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAM 324

Human   313 LNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSPRF 377
            |:..|::....|.|. |.|.:.||:||..:||....| ..|:.::.....::.||........|.
  Fly   325 LSNEFQRHHGMSAHK-DVPHVVFDYHQECRGGNFSAL-AKLKERIVACGANYGVFHASNGQVLRE 387

Human   378 QKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSK-PIVDRFVESFKAMWSLNGHSLSKV 441
            |.|.:|.||||||||||.||:::.|:.|.:||:.|.:..| ..:.||.|.|:.||..||:.:||:
  Fly   388 QFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQMWINNGNEVSKI 452

Human   442 FTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTA 506
            :.|:.|::|.:   ||.|||||.:||||:|..|..|||||.:||||.....|:||:..:||.|..
  Fly   453 YAGTGAIQGGS---KLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNM 514

Human   507 LLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGA--- 568
            |.....:|:.:.:|.:|:...:..|:|:||:||||||.|||.|.:.: |.|||||...|:.:
  Fly   515 LHAPTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKDS-LADWLLDCHALARSKAL 578

Human   569 ----TDSQDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQL 629
                ..|::...|.||:|:||||:|:|:|.||:.|||.|.|:|.|:|||.|||.:.|:|||..||
  Fly   579 VDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTYQQL 643

Human   630 VGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVK 694
            |||||||::||.|.|.|||||||.||||:||..|||||..|||..|.||.||:|:|..||||||.
  Fly   644 VGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVA 708

Human   695 ERNEDYKEITQKLCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQ 759
            |||.||.|||:||.|||||.:.|||:||||||||||||:..:|:...|:..|...:||||||:.:
  Fly   709 ERNADYAEITRKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKDELKECVRNGDLSTVLEFDQLRKE 773

Human   760 KSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLD 824
            :.:|.:|.:|.||.|.|.||||||:.|..||||:|.|.|||||||||.|:|          .|.:
  Fly   774 QEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRK----------ALAE 828

Human   825 SDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLD 889
            .|.     ....|:||.|.:|||:||:.||||||:||::.|:.|:|...|..||::|....||.|
  Fly   829 GDF-----AASAWNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIRDLGPPD 888

Human   890 ATVVVNL---------QSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSA 945
            :|:||::         ..||:     :.|::.:.|:..|...|.:.|||..:..|.|||.|..||
  Fly   889 STIVVHVLESSATGDEDGPTI-----YDENVMSALITELSKMGEVTLVRYVEDTMWVTFRDGESA 948

Human   946 LSVLDVDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPV--SPTANSCLLEENFDFTSLDY 1008
            |:......::|.|..:.:..|:|||...:..||.....:..|:  :|..::.||:.
  Fly   949 LNASSKKSIQVCGLDLILELKSKDWQHLVDSEIELCTTNTIPLCANPVEHAQLLQA--------- 1004

Human  1009 ESEGDILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDAD 1073
                         :..|..|.               |......||::.|.....|..|.:.....
  Fly  1005 -------------ITPELPQR---------------PKQPPTRPPARPPMPMSPKNSPRHLPHVG 1041

Human  1074 LVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSI 1138
            ::.:                    ||...:||.|||....|
  Fly  1042 VISI--------------------VPKPAKPPMPPQPQSQP------------------------ 1062

Human  1139 LQTARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAPRDL 1203
                 |:| :|.||..|      |.....:.||.:.:::                     :|.:|
  Fly  1063 -----LIP-SPLQPQVA------PPRPPAMDTTPSSKSQ---------------------SPTEL 1094

Human  1204 EASSEPEPTPGAAKPETP---QAPPLLPRR-PPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFT 1264
            .::|....:.|...|..|   ..||..||: ...:...:..|| |:.|.|..|.
  Fly  1095 VSASSSTSSSGKTSPTAPAVLSGPPTPPRQMQSKQATPVSTPT-RQVGSPKDPI----------- 1147

Human  1265 IGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVPPPLEAPPLV 1329
              |.:|:.|....:.......||.||            |..||.  .||..||.:.||   |||.
  Fly  1148 --PSDTAYETASNIYEEIQEDVPAPR------------HPPPAG--PPPVIGAPMGPP---PPLP 1193

Human  1330 ----PKVPPRRKKSAP 1341
                |...|.|..:||
  Fly  1194 NRRGPPPIPNRSGNAP 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SYNJ2	NP_003889.1	Syja_N	61..342	CDD:280532	146/293 (50%)
		EEP	530..861	CDD:294334	186/337 (55%)
		DUF1866	872..1008	CDD:286093	39/146 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1027..1073		7/45 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1085..1166		15/80 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1190..1405		40/160 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1427..1473
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	146/293 (50%)
		INPP5c_Synj	538..863	CDD:197323	188/340 (55%)
		DUF1866	862..1008	CDD:286093	42/172 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146120
Domainoid	1	1.000	86	1.000	Domainoid score	I8104
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	1	1.000	-	-		FOG0002172
OrthoInspector	1	1.000	-	-		otm41819
orthoMCL	1	0.900	-	-		OOG6_101787
Panther	1	1.100	-	-	O	PTHR11200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1445
SonicParanoid	1	1.000	-	-		X1883
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.740