Protein Alignment CCKBR and AstA-R1

DIOPT Version :10

• Sequence 1: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Sequence 2: NP_524700.1
• Gene: AstA-R1 / 44126
• FlyBaseID: FBgn0266429
• Length: 394
• Species: Drosophila melanogaster
• Alignment Length: 430
• Identity: 89/430 - (20%)
• Similarity: 163/430 - (37%)
• Gaps: 150/430 - (34%)

Human    61 YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTV 125
            :.:|....:.||.|:|:|:..::::|:.||..:::|||||:|..:.|:|||....::..:.||.|
  Fly    81 FGIIGFAGLLGNGLVILVVVANQQMRSTTNLLIINLAVSDILFVIFCVPFTATDYVLPEWPFGNV 145

Human   126 ICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYP 190
            .||.|.|::.|:...|..:||.::.:|:.|:..|:.:...:|..:|...|:..|:......:|..
  Fly   146 WCKFVQYMIVVTCHCSVYTLVLMSFDRFLAVVHPVTSMSLRTERNATLAIMCAWITIVTTAIPVA 210

Human   191 V---YTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFD 252
            :   ..:.|..|.....||.    :...:.||::...:.||:...|..:.  ||. .||:|:.
  Fly   211 LSHSVRIYQYHGNAGTACVF----STEEEIWSLVGFQVSFFLSSYVAPLT--LIC-FLYMGML-- 266

Human   253 GDSDSDSQSRVRNQGGLPGGAGPREQNLGEAELWRATGPAGVGGTEMKVRVRRKLEMELSWERRS 317
                                          |.||:
  Fly   267 ------------------------------ARLWK------------------------------ 271

Human   318 GGDWAGDWGDSPFSLTAHPLCSGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPG 382
                                                                         :||
  Fly   272 -------------------------------------------------------------SAP- 274

Human   383 PGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFI--- 444
               |.:|:......|:||.||::|:|:.|.:||||::.....:|.:..|      |:.:|.|
  Fly   275 ---GCKPSAESRKGKRRVTRMVVVVVLAFAICWLPIHVILVLKALNLYG------GSHLSVIIQI 330

Human   445 --HLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPP 482
              |:::|.::|:||::|.|:...||:|..:..  .|..||
  Fly   331 ISHVVAYTNSCINPILYAFLSDNFRKAFRKVV--WCGSPP 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:475119	85/416 (20%)
		TM helix 1	57..81	CDD:320645	6/19 (32%)
		TM helix 2	90..112	CDD:320645	10/21 (48%)
		TM helix 3	128..150	CDD:320645	7/21 (33%)
		TM helix 4	173..189	CDD:320645	2/15 (13%)
		TM helix 5	216..239	CDD:320645	5/22 (23%)
		TM helix 6	401..423	CDD:320645	9/21 (43%)
		TM helix 7	438..463	CDD:320645	10/29 (34%)
AstA-R1	NP_524700.1	7tmA_AstA_R_insect	75..358	CDD:320224	85/416 (20%)
		TM helix 1	76..102	CDD:320224	6/20 (30%)
		TM helix 2	109..135	CDD:320224	12/25 (48%)
		TM helix 3	147..177	CDD:320224	10/29 (34%)
		TM helix 4	189..209	CDD:320224	3/19 (16%)
		TM helix 5	239..268	CDD:320224	8/63 (13%)
		TM helix 6	284..314	CDD:320224	12/29 (41%)
		TM helix 7	326..351	CDD:320224	8/24 (33%)