Protein Alignment CCKBR and TkR99D

DIOPT Version :10

• Sequence 1: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Sequence 2: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 429
• Identity: 91/429 - (21%)
• Similarity: 169/429 - (39%)
• Gaps: 157/429 - (36%)

Human    57 RITLYAVIF----LMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLM 117
            |..|::::|    :::.|||::::.::..::|:|||||.|:::|:::|.:::...:.|.....|.
  Fly   100 RQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLD 164

Human   118 GTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLS 182
            ..:.||...||...::..:|:..|..:|:||:::||.||.||||.|:.:..:.|...::  ||.|
  Fly   165 SDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLAIAAVI--WLAS 227

Human   183 GLLMVPYPVYTVVQPVGPRVLQ----CVHRWPS-----ARVRQTWSVLLLLLLFFIPGVVMAVAY 238
            .|:..|..:....:.|..|.|.    |...||.     :.:...:::|:::|.:|:|.|.|.|.|
  Fly   228 TLISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSMTVTY 292

Human   239 GLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGGAGPREQNLGEAELWRATGPAGVGGTEMKVRV 303
            ..:..||
  Fly   293 SRVGIEL---------------------------------------------------------- 299

Human   304 RRKLEMELSWERRSGGDWAGDWGDSPFSLTAHPLCSGAVHQNGRCRPETGAVGEDSDGCYVQLPR 368
                                 ||....               |.|.|.             |:..
  Fly   300 ---------------------WGSKTI---------------GECTPR-------------QVEN 315

Human   369 SRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAH 433
            .|                         :|:|||:|::|:|::|.:||||.:|     .|.....:
  Fly   316 VR-------------------------SKRRVVKMMIVVVLIFAICWLPFHS-----YFIITSCY 350

Human   434 RALSGAPI-----SFIHLLSYASACVNPLVYCFMHRRFR 467
            .|::.||.     ..|:.|:.:::..||::||:|:.|||
  Fly   351 PAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFR 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:475119	91/429 (21%)
		TM helix 1	57..81	CDD:320645	6/27 (22%)
		TM helix 2	90..112	CDD:320645	5/21 (24%)
		TM helix 3	128..150	CDD:320645	6/21 (29%)
		TM helix 4	173..189	CDD:320645	4/15 (27%)
		TM helix 5	216..239	CDD:320645	7/22 (32%)
		TM helix 6	401..423	CDD:320645	10/21 (48%)
		TM helix 7	438..463	CDD:320645	8/29 (28%)
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	90/427 (21%)
		TM helix 1	103..129	CDD:320512	5/25 (20%)
		TM helix 2	136..162	CDD:320512	6/25 (24%)
		TM helix 3	174..204	CDD:320512	10/29 (34%)
		TM helix 4	215..236	CDD:320512	6/22 (27%)
		TM helix 5	269..298	CDD:320512	8/28 (29%)
		TM helix 6	317..347	CDD:320512	15/59 (25%)
		TM helix 7	360..385	CDD:320512	6/24 (25%)