Protein Alignment CCKBR and AstA-R2

DIOPT Version :10

• Sequence 1: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Sequence 2: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Alignment Length: 512
• Identity: 100/512 - (19%)
• Similarity: 177/512 - (34%)
• Gaps: 192/512 - (37%)

Human    30 NSSSVGNLSCEPPR----IRGAGTRELELAIRITL-------YAVIFLMSVGGNMLIIVVLGLSR 83
            |::.:.|:|....|    |....|.|..|||..||       :.||.:....||:|:|:|:..:.
  Fly     3 NTTMLANISLNATRNEENITSFFTDEEWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFNN 67

Human    84 RLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAI 148
            .:|:.||..:::||.:||:..:.|:|||....::..:.:|...|::|.||:.|:...|..:||.:
  Fly    68 NMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLM 132

Human   149 ALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPV---------------------- 191
            :::|:.|:..|:::|:.:|.:.....||..|::  :|:|..||
  Fly   133 SIDRFLAVVHPIRSRMMRTENITLIAIVTLWIV--VLVVSVPVAFTHDVVVDYDAKKNITYGMCT 195

Human   192 YTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSD 256
            :|....:|||               |:.|...:..:.:|.::::   ||..|.:
  Fly   196 FTTNDFLGPR---------------TYQVTFFISSYLLPLMIIS---GLYMRMI----------- 231

Human   257 SDSQSRVRNQGGLPGGAGPREQNLGEAELWRATGPAGVGGTEMKVRVRRKLEMELSWERRSGGDW 321
                                      ..|||
  Fly   232 --------------------------MRLWR---------------------------------- 236

Human   322 AGDWGDSPFSLTAHPLCSGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSG 386
                                                                         .|:|
  Fly   237 -------------------------------------------------------------QGTG 240

Human   387 SRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYAS 451
            .|.::.....:|||.|:::|:|:.|...||||......::.|....:.............|:|:|
  Fly   241 VRMSKESQRGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTLTKLVIQVTAQTLAYSS 305

Human   452 ACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYT 508
            :|:|||:|.|:...||:|..: ...|..|....      ..|.|.|...|.:|.|.|
  Fly   306 SCINPLLYAFLSENFRKAFYK-AVNCSSRYQNY------TSDLPPPRKTSCARTSTT 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:475119	82/443 (19%)
		TM helix 1	57..81	CDD:320645	9/30 (30%)
		TM helix 2	90..112	CDD:320645	8/21 (38%)
		TM helix 3	128..150	CDD:320645	7/21 (33%)
		TM helix 4	173..189	CDD:320645	5/15 (33%)
		TM helix 5	216..239	CDD:320645	3/22 (14%)
		TM helix 6	401..423	CDD:320645	8/21 (38%)
		TM helix 7	438..463	CDD:320645	9/24 (38%)
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	78/436 (18%)
		TM helix 1	40..66	CDD:320224	7/25 (28%)
		TM helix 2	73..99	CDD:320224	10/25 (40%)
		TM helix 3	111..141	CDD:320224	10/29 (34%)
		TM helix 4	153..173	CDD:320224	5/21 (24%)
		TM helix 5	204..233	CDD:320224	8/83 (10%)
		TM helix 6	249..279	CDD:320224	11/29 (38%)
		TM helix 7	292..317	CDD:320224	9/24 (38%)