Protein Alignment CCKBR and TkR86C

DIOPT Version :10

• Sequence 1: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Sequence 2: NP_001097741.1
• Gene: TkR86C / 41286
• FlyBaseID: FBgn0004841
• Length: 555
• Species: Drosophila melanogaster
• Alignment Length: 495
• Identity: 107/495 - (21%)
• Similarity: 188/495 - (37%)
• Gaps: 190/495 - (38%)

Human    49 TRELELA-IRITLYAVIF----LMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACM 108
            ||..||. .:.|::|:||    .:::.||.:::.::...|.:|||||.|||:|:::|||::....
  Fly    73 TRPYELPWEQKTIWAIIFGLMMFVAIAGNGIVLWIVTGHRSMRTVTNYFLLNLSIADLLMSSLNC 137

Human   109 PFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAAR 173
            .|..:..|...:.||::.|...:::..|:||.|..:||||:.:||.||..||:.|.  :|.....
  Fly   138 VFNFIFMLNSDWPFGSIYCTINNFVANVTVSTSVFTLVAISFDRYIAIVHPLKRRT--SRRKVRI 200

Human   174 VIVATWLLSGLLMVPYPVYTVVQPV----GPRVLQCVHRWPSAR-----VRQTWSVLLLLLLFFI 229
            ::|..|.||.:|..|..:|:.:...    |.....|...||..|     ....:::::|:|.:.|
  Fly   201 ILVLIWALSCVLSAPCLLYSSIMTKHYYNGKSRTVCFMMWPDGRYPTSMADYAYNLIILVLTYGI 265

Human   230 PGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGGAGPREQNLGEAELWRATGPAGV 294
            |.:||.:.|.|:.|.|
  Fly   266 PMIVMLICYSLMGRVL------------------------------------------------- 281

Human   295 GGTEMKVRVRRKLEMELSWERRSGGDWAGDWGDSPFSLTAHPLCSGAVHQNGRCRPETGAVGEDS 359
                                          ||                         :.::||::
  Fly   282 ------------------------------WG-------------------------SRSIGENT 291

Human   360 DGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLP-----VY 419
            |       |...:::                     :|::||||.:.||.:|.:||||     :|
  Fly   292 D-------RQMESMK---------------------SKRKVVRMFIAIVSIFAICWLPYHLFFIY 328

Human   420 SANTWRAFDGPGAHRALSGAPISFIHL----LSYASACVNPLVYCFMHRRFRQACLETCARCCP- 479
            :.:.         ::..|...:..::|    |:.::|.||||:|.:|::|||.........||.
  Fly   329 AYHN---------NQVASTKYVQHMYLGFYWLAMSNAMVNPLIYYWMNKRFRMYFQRIICCCCVG 384

Human   480 ------RPPRAR-----------------PRALPDEDPPT 496
                  ..|::|                 ..:||:..|||
  Fly   385 LTRHRFDSPKSRLTNKNSSNRHTRGGYTVAHSLPNSSPPT 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:475119	94/437 (22%)
		TM helix 1	57..81	CDD:320645	6/27 (22%)
		TM helix 2	90..112	CDD:320645	9/21 (43%)
		TM helix 3	128..150	CDD:320645	8/21 (38%)
		TM helix 4	173..189	CDD:320645	5/15 (33%)
		TM helix 5	216..239	CDD:320645	6/22 (27%)
		TM helix 6	401..423	CDD:320645	11/26 (42%)
		TM helix 7	438..463	CDD:320645	8/28 (29%)
TkR86C	NP_001097741.1	7tmA_TACR	84..374	CDD:320512	94/432 (22%)
		TM helix 1	85..111	CDD:320512	5/25 (20%)
		TM helix 2	118..144	CDD:320512	10/25 (40%)
		TM helix 3	156..186	CDD:320512	12/29 (41%)
		TM helix 4	197..218	CDD:320512	6/20 (30%)
		TM helix 5	251..280	CDD:320512	8/28 (29%)
		TM helix 6	299..329	CDD:320512	12/50 (24%)
		TM helix 7	342..367	CDD:320512	8/24 (33%)