Protein Alignment CCKBR and sNPF-R

DIOPT Version :10

• Sequence 1: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Sequence 2: NP_524176.1
• Gene: sNPF-R / 40195
• FlyBaseID: FBgn0036934
• Length: 600
• Species: Drosophila melanogaster
• Alignment Length: 479
• Identity: 121/479 - (25%)
• Similarity: 194/479 - (40%)
• Gaps: 135/479 - (28%)

Human    60 LYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGT 124
            |||.:|::.|.||:|:..|:..:|.::||||.|:.:||:||:||.|..:|||.|...||.:.||.
  Fly    69 LYATVFVLGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPFTPLYTFMGRWAFGR 133

Human   125 VICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPY 189
            .:|..||:..|.|:.:|||:|.:||::||..|..|...|:  ..|....:||:.|:::.|..|||
  Fly   134 SLCHLVSFAQGCSIYISTLTLTSIAIDRYFVIIYPFHPRM--KLSTCIGIIVSIWVIALLATVPY 196

Human   190 PVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGD 254
            .:|          ::..:...:.  .||.:..|:.....:.|..:|...|.|..
  Fly   197 GMY----------MKMTNELVNG--TQTGNETLVEATLMLNGSFVAQGSGFIEA----------- 238

Human   255 SDSDSQSRVRNQGGLPGGAGPR--------EQNLGEAELWRATGPAGVGGTEMKVRVRRKLEMEL 311
            .||.|.::...|....|..||.        |:|      |.:.....|.|.     :...|:..|
  Fly   239 PDSTSATQAYMQVMTAGSTGPEMPYVRVYCEEN------WPSEQYRKVFGA-----ITTTLQFVL 292

Human   312 SWERRSGGDWAGDWGDSPFSLTAHPLCSGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELT 376
                             ||.:.:.                          |||.:     :::|.
  Fly   293 -----------------PFFIISI--------------------------CYVWI-----SVKLN 309

Human   377 ALTAPGPGS-GSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVY----------SANTWRAFDGP 430
            ......||| .||..:|....|||..|||:.:|.:|.|.|||:.          .:|.||.:
  Fly   310 QRARAKPGSKSSRREEADRDRKKRTNRMLIAMVAVFGLSWLPINVVNIFDDFDDKSNEWRFY--- 371

Human   431 GAHRALSGAPISFI---HLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDE 492
                      |.|.   |.::.:|.|.||.:|.:::..||               :.....||..
  Fly   372 ----------ILFFFVAHSIAMSSTCYNPFLYAWLNENFR---------------KEFKHVLPCF 411

Human   493 DPPTPSIASLSR-LSYTTISTLGP 515
            :|...:|.:::| .:.:..:|.||
  Fly   412 NPSNNNIINITRGYNRSDRNTCGP 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:475119	113/431 (26%)
		TM helix 1	57..81	CDD:320645	9/20 (45%)
		TM helix 2	90..112	CDD:320645	11/21 (52%)
		TM helix 3	128..150	CDD:320645	9/21 (43%)
		TM helix 4	173..189	CDD:320645	5/15 (33%)
		TM helix 5	216..239	CDD:320645	5/22 (23%)
		TM helix 6	401..423	CDD:320645	9/31 (29%)
		TM helix 7	438..463	CDD:320645	8/27 (30%)
sNPF-R	NP_524176.1	7tmA_NPYR-like	64..404	CDD:320331	113/446 (25%)
		TM helix 1	65..91	CDD:320331	9/21 (43%)
		TM helix 2	98..123	CDD:320331	13/24 (54%)
		TM helix 3	136..166	CDD:320331	13/29 (45%)
		TM helix 4	177..198	CDD:320331	7/20 (35%)
		TM helix 5	278..307	CDD:320331	9/81 (11%)
		TM helix 6	329..359	CDD:320331	12/29 (41%)
		TM helix 7	372..397	CDD:320331	8/24 (33%)