Protein Alignment CCKBR and AstC-R1

DIOPT Version :10

• Sequence 1: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Sequence 2: NP_649040.2
• Gene: AstC-R1 / 40020
• FlyBaseID: FBgn0036790
• Length: 483
• Species: Drosophila melanogaster
• Alignment Length: 485
• Identity: 106/485 - (21%)
• Similarity: 180/485 - (37%)
• Gaps: 167/485 - (34%)

Human    58 ITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIF 122
            :.||..:.::.:.||.|:|.|:....:::||||.::|:|||:|....:. :||.|....:.::.|
  Fly    81 VVLYGFVCIIGLFGNTLVIYVVLRFSKMQTVTNIYILNLAVADECFLIG-IPFLLYTMRICSWRF 144

Human   123 GTVICKAVSYLMGVSVS--VSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVA-TWLLSGL 184
            |..:|||  |::..|::  .|::.|:.::.:||.|:|.|:.:..::| .|.|:|:.| .|..|.:
  Fly   145 GEFMCKA--YMVSTSITSFTSSIFLLIMSADRYIAVCHPISSPRYRT-LHIAKVVSAIAWSTSAV 206

Human   185 LMVPYPVY--TVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYL 247
            ||:|..:|  ||.|..|.. ..|...||.|..:.:.:..:|...|                   |
  Fly   207 LMLPVILYASTVEQEDGIN-YSCNIMWPDAYKKHSGTTFILYTFF-------------------L 251

Human   248 GLRFDGDSDSDSQSRVRNQGGLPGGAGPREQNLGEAELWRATGPAGVGGTEMKVRVRRKLEMELS 312
            |.
  Fly   252 GF--------------------------------------------------------------- 253

Human   313 WERRSGGDWAGDWGDSPFSLTAHPLCSGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTA 377
                                 |.|||                           ...|...|.:..
  Fly   254 ---------------------ATPLC---------------------------FILSFYYLVIRK 270

Human   378 LTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPIS 442
            |.:.||..|:: ::.|..|.::|.|::|.::.::.|||||.:.:........| |.|.||...|.
  Fly   271 LRSVGPKPGTK-SKEKRRAHRKVTRLVLTVISVYILCWLPHWISQVALIHSNP-AQRDLSRLEIL 333

Human   443 FIHLLS---YASACVNPLVYCFMHRRFRQACLE--TC-------ARCCPRP---------PRARP 486
            ...||.   |:::.|||::|.|:...||::..:  ||       |:....|         .|...
  Fly   334 IFLLLGALVYSNSAVNPILYAFLSENFRKSFFKAFTCMNKQDINAQLQLEPSVFTKQGSKKRGGS 398

Human   487 RALPDEDPPTPSIASL----SRLSYTTIST 512
            :.|...:|..|.:..|    :..|.||.||
  Fly   399 KRLLTSNPQIPPLLPLNAGNNNSSTTTSST 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:475119	92/419 (22%)
		TM helix 1	57..81	CDD:320645	7/22 (32%)
		TM helix 2	90..112	CDD:320645	8/21 (38%)
		TM helix 3	128..150	CDD:320645	6/23 (26%)
		TM helix 4	173..189	CDD:320645	6/16 (38%)
		TM helix 5	216..239	CDD:320645	2/22 (9%)
		TM helix 6	401..423	CDD:320645	7/21 (33%)
		TM helix 7	438..463	CDD:320645	9/27 (33%)
AstC-R1	NP_649040.2	7tmA_AstC_insect	78..364	CDD:320222	92/419 (22%)
		TM helix 1	79..105	CDD:320222	7/23 (30%)
		TM helix 2	112..138	CDD:320222	10/26 (38%)
		TM helix 3	149..179	CDD:320222	10/31 (32%)
		TM helix 4	191..213	CDD:320222	9/21 (43%)
		TM helix 5	241..270	CDD:320222	10/158 (6%)
		TM helix 6	287..317	CDD:320222	9/29 (31%)
		TM helix 7	332..357	CDD:320222	9/24 (38%)