Protein Alignment CCKBR and Lkr

DIOPT Version :10

• Sequence 1: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Sequence 2: NP_647968.3
• Gene: Lkr / 38622
• FlyBaseID: FBgn0035610
• Length: 542
• Species: Drosophila melanogaster
• Alignment Length: 488
• Identity: 95/488 - (19%)
• Similarity: 168/488 - (34%)
• Gaps: 201/488 - (41%)

Human    24 PGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTV 88
            |||.  ..:....|...|..|         :|:....|..|.:::|.||.|:|.|:..:|::|||
  Fly    16 PGAE--EEAEFERLYAAPAEI---------VALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTV 69

Human    89 TNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERY 153
            ||.::.:||.:|:::.:.|:||.....|:.::.....:|....::..:||:||..:|.|||::|:
  Fly    70 TNMYIANLAFADVIIGLFCIPFQFQAALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRH 134

Human   154 SAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPV-----------------YTVVQPVGPR 201
            .||..||:||  .|:..:..:|...|:|:.|..||:.:                 |.|.:|.
  Fly   135 RAIINPLRAR--PTKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERFRENNETYNVTRPF--- 194

Human   202 VLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQ 266
               |:::..|....|::...|:.:.:.:|..|::..|
  Fly   195 ---CMNKNLSDDQLQSFRYTLVFVQYLVPFCVISFVY---------------------------- 228

Human   267 GGLPGGAGPREQNLGEAELWRATGPAGVGGTEMKVRVRRKLEMELSWERRSGGDWAGDWGDSPFS 331
                                          .:|.||:                     ||
  Fly   229 ------------------------------IQMAVRL---------------------WG----- 237

Human   332 LTAHPLCSGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLA 396
                                                          ..|||....||.. ..|..
  Fly   238 ----------------------------------------------TRAPGNAQDSRDI-TLLKN 255

Human   397 KKRVVRMLLVIVVLFFLCWLPVYSAN-----------------TWRAFDGPGAHRALSGAPISFI 444
            ||:|::||:::|::|.|||||:...|                 .|...|
  Fly   256 KKKVIKMLIIVVIIFGLCWLPLQLYNILYVTIPEINDYHFISIVWFCCD---------------- 304

Human   445 HLLSYASACVNPLVYCFMHRRFRQACLETCARC 477
             .|:.:::|.||.:|...:.:|::...:..|.|
  Fly   305 -WLAMSNSCYNPFIYGIYNEKFKREFNKRFAAC 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:475119	87/448 (19%)
		TM helix 1	57..81	CDD:320645	8/23 (35%)
		TM helix 2	90..112	CDD:320645	7/21 (33%)
		TM helix 3	128..150	CDD:320645	7/21 (33%)
		TM helix 4	173..189	CDD:320645	5/15 (33%)
		TM helix 5	216..239	CDD:320645	4/22 (18%)
		TM helix 6	401..423	CDD:320645	10/38 (26%)
		TM helix 7	438..463	CDD:320645	5/24 (21%)
Lkr	NP_647968.3	7tmA_leucokinin-like	36..329	CDD:320515	87/448 (19%)
		TM helix 1	37..63	CDD:320515	8/25 (32%)
		TM helix 2	70..95	CDD:320515	8/24 (33%)
		TM helix 3	108..138	CDD:320515	11/29 (38%)
		TM helix 4	149..170	CDD:320515	6/20 (30%)
		TM helix 5	205..234	CDD:320515	6/86 (7%)
		TM helix 6	254..284	CDD:320515	13/29 (45%)
		TM helix 7	297..322	CDD:320515	7/41 (17%)