Protein Alignment CCKBR and ckr-1

DIOPT Version :10

• Sequence 1: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Sequence 2: NP_491918.3
• Gene: ckr-1 / 188774
• WormBaseID: WBGene00020712
• Length: 421
• Species: Caenorhabditis elegans
• Alignment Length: 485
• Identity: 138/485 - (28%)
• Similarity: 211/485 - (43%)
• Gaps: 120/485 - (24%)

Human    53 ELAIRITLYAV----IFL----MSVGGNMLIIV-VLGLSRRLRTVTNAFLLSLAVSDLLLAVACM 108
            |.::.|:.|.:    |||    :|:.||.::|: :||.|.|.|::||.:||:||.:|||.::.|:
 Worm     4 ECSVIISPYTIMISSIFLLCLILSLLGNAIVILTILGKSHRSRSITNFYLLNLAFADLLRSIICI 68

Human   109 PFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAAR 173
            |.|||..|...::.|..:||.|::|..|.|..|..:|..||:|||.||||||::|.|||:..|..
 Worm    69 PSTLLGELTQCWLLGAAMCKIVAFLQPVGVCASAYTLAVIAIERYYAICRPLESRKWQTKKRALI 133

Human   174 VIVATW-------LLSGLLMVPYP-VYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIP 230
            .|...|       |.|..|....| .:|.....||            .|...:.:.|...|.|:|
 Worm   134 TISLVWCFSFSANLTSLFLYDANPGKFTCDSTKGP------------LVDFIYQLYLTFTLLFVP 186

Human   231 GVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGGAGPREQNLGEAELWRATGPAGVG 295
            ..:|...||.:.  :.|....:.|..:..|..:...  ||..|...:        |..:....|
 Worm   187 LALMVGLYGNVI--ITLNTAINSDHPTVEQQMIEKT--LPSRASFSD--------WFVSAVQRV- 238

Human   296 GTEMKV---RVRRKLEMELSWERRSGGDWAGDWGDSPFSLTAHPLCSGAVHQNGRCRPETGAVGE 357
             ..|||   ..:.|.:..||..:.||             |:..|                   ..
 Worm   239 -PSMKVVSKTFQFKEKNSLSIPQTSG-------------LSVRP-------------------SR 270

Human   358 DSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAK--LLAKKRVVRMLLVIVVLFFLCWLPVY- 419
            .|...:...||.  :.::|.|.        |.|..:  |:|||:|.|||:.:|::|..||:|.|
 Worm   271 SSFSSFFSTPRG--SFDVTMLL--------RSTNQEKILIAKKKVTRMLITLVIVFAFCWVPSYL 325

Human   420 -----------SANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLET 473
                       :.:.|    .||.:.:|:        :::|.|:..||:.||||::.||.:.|
 Worm   326 YWLLLRMAELAATDLW----NPGLNSSLT--------IMTYISSLANPITYCFMNKSFRSSVL-- 376

Human   474 CARCCPRP--PRARPRALPD-EDPPTPSIA 500
             |.|.|:|  |..|..|||. :.|.:|:.|
 Worm   377 -AYCRPKPKRPLTRCSALPTRKSPSSPTHA 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:475119	124/448 (28%)
		TM helix 1	57..81	CDD:320645	10/32 (31%)
		TM helix 2	90..112	CDD:320645	10/21 (48%)
		TM helix 3	128..150	CDD:320645	8/21 (38%)
		TM helix 4	173..189	CDD:320645	5/22 (23%)
		TM helix 5	216..239	CDD:320645	5/22 (23%)
		TM helix 6	401..423	CDD:320645	9/33 (27%)
		TM helix 7	438..463	CDD:320645	7/24 (29%)
ckr-1	NP_491918.3	7tmA_CCKR-like	30..375	CDD:320124	118/424 (28%)
		TM helix 2	49..75	CDD:320124	14/25 (56%)
		TM helix 3	87..117	CDD:320124	14/29 (48%)
		TM helix 4	131..149	CDD:320124	4/17 (24%)
		TM helix 5	171..196	CDD:320124	6/24 (25%)
		TM helix 6	300..330	CDD:320124	13/29 (45%)
		TM helix 7	343..368	CDD:320124	10/32 (31%)