Protein Alignment CCKBR and cckbrb

DIOPT Version :10

• Sequence 1: NP_001350481.1
• Gene: CCKBR / 887
• HGNCID: 1571
• Length: 516
• Species: Homo sapiens
• Sequence 2: XP_017213239.2
• Gene: cckbrb / 100331465
• ZFINID: ZDB-GENE-201012-1
• Length: 442
• Species: Danio rerio
• Alignment Length: 534
• Identity: 244/534 - (45%)
• Similarity: 329/534 - (61%)
• Gaps: 112/534 - (20%)

Human     1 MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNL-----SCEP----PRIRGAGTRELELAI 56
            |:|..||.:      |..|.|....|.:||.||.|:|     :||.    |:|..|..:|:: ::
Zfish     1 MDLQLLNDT------GIWACLQLHNASILNRSSNGSLEVPNGTCEDALLLPKIEPARAKEMD-SL 58

Human    57 RITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFI 121
            ||.||.:|||:||.||:||||||.:::|:|||||:||||||:|||::||.||||||:|||||.||
Zfish    59 RILLYCLIFLLSVFGNLLIIVVLMVNKRMRTVTNSFLLSLAISDLMMAVVCMPFTLIPNLMGDFI 123

Human   122 FGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLM 186
            ||..:||.|:||||:||.:||.||||||:|||||||.||::|.|||||||.:||.:||::|.|:|
Zfish   124 FGAAMCKIVAYLMGISVCISTFSLVAIAIERYSAICNPLKSRAWQTRSHAYKVIASTWVVSFLIM 188

Human   187 VPYPVY-TVVQPVGPRVL---QCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYL 247
            .|||:: |:|:......:   .|.|.|.::.|.:.|.:|||.:|||||||||.:||||||||||.
Zfish   189 TPYPIFSTLVEFTKNNNITGHMCRHDWMNSEVEKAWCILLLFVLFFIPGVVMIIAYGLISRELYR 253

Human   248 GLRFDGDSDSDSQSRVRNQGGLPGGAGPREQNLGEAELWRATGPAGVGGTEMKVRVRRKLEMELS 312
            |::|                                ||.:..|..|:
Zfish   254 GIQF--------------------------------ELEQKKGQCGM------------------ 268

Human   313 WERRSGGDWAGDWGDSPFSLTAHPLCSGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTA 377
               ::|             ::|..|.|                .:|.||||:|:.:...::|::|
Zfish   269 ---KNG-------------ISATVLIS----------------SDDGDGCYIQVSKRPNSMEMSA 301

Human   378 LTAPGPGSGSRP----TQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSG 438
            ||..|.....||    ::|||:|||||:|||:|||.:||:||:||||.|||:|||...|||||||
Zfish   302 LTPTGSAKVDRPRSNTSEAKLMAKKRVIRMLIVIVAMFFICWMPVYSVNTWKAFDLASAHRALSG 366

Human   439 APISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCC-PRPPRARPRALPD-EDPPTPSIAS 501
            |||||||||||.||||||::||||::|||:|.|.|.:.|| |    .|.|...: :|..|.:.||
Zfish   367 APISFIHLLSYTSACVNPIIYCFMNKRFRKALLATFSCCCWP----CRKRGFREGDDEVTATGAS 427

Human   502 LSRLSYTTISTLGP 515
            :|:.:|||:||:||
Zfish   428 MSKFNYTTVSTMGP 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKBR	NP_001350481.1	7tm_GPCRs	55..470	CDD:475119	204/422 (48%)
		TM helix 1	57..81	CDD:320645	17/23 (74%)
		TM helix 2	90..112	CDD:320645	16/21 (76%)
		TM helix 3	128..150	CDD:320645	15/21 (71%)
		TM helix 4	173..189	CDD:320645	7/15 (47%)
		TM helix 5	216..239	CDD:320645	14/22 (64%)
		TM helix 6	401..423	CDD:320645	14/21 (67%)
		TM helix 7	438..463	CDD:320645	21/24 (88%)
cckbrb	XP_017213239.2	None