Protein Alignment SYNJ1 and Synj

DIOPT Version :9

• Sequence 1: NP_003886.3
• Gene: SYNJ1 / 8867
• HGNCID: 11503
• Length: 1612
• Species: Homo sapiens
• Sequence 2: NP_001246454.1
• Gene: Synj / 37517
• FlyBaseID: FBgn0034691
• Length: 1218
• Species: Drosophila melanogaster
• Alignment Length: 1349
• Identity: 627/1349 - (46%)
• Similarity: 832/1349 - (61%)
• Gaps: 179/1349 - (13%)

Human    40 MAFSKGFRIYHK-LDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAYGLLG 103
            ||.||..|:..| :.|.|.|:::|.|:|.:.::|||.|||:|:..|.:.|:..|:||.||||.||
  Fly     1 MAMSKVIRVLEKSIAPSPHSVLLEHRNKSDSILFESHAVALLTQQETDVIRKQYTKVCDAYGCLG 65

Human   104 VLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVRKVLNSGNFY 168
            .|:||.|::.:.:|||||||:|:|||.:.|:||:|.|.|:||:..:.:||:||||||:||||.||
  Fly    66 ALQLNAGESTVLFLVLVTGCVSMGKIGDIEIFRITQTTFVSLQNAAPNEDKISEVRKLLNSGTFY 130

Human   169 FAW-----SASGIS---LDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGG 225
            ||.     ||||.|   .|::|.|.|..|.|.||||||||:.:|:||..:|::|..|||:.|||.
  Fly   131 FAHTNASASASGASSYRFDITLCAQRRQQTQETDNRFFWNRMMHIHLMRFGIDCQSWLLQAMCGS 195

Human   226 VEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLDDSVSSFIQIRG 290
            ||:||:|...|||:|.:||||||||||||||||||||:|:||||||||||:|:|..|:|::|.||
  Fly   196 VEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTRG 260

Human   291 SVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLL-----GSKEGEHML 350
            ||||||||||:|||||:|::|||||.:|.|||||...::..||.|.:||||     ||||||.||
  Fly   261 SVPLFWEQPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAML 325

Human   351 SKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFFYFNGSEVQRCQS 415
            |..||.|...|.| .|:..|.|||||..:||....|..:.:..|....:||.|:.:..:|.|.|.
  Fly   326 SNEFQRHHGMSAH-KDVPHVVFDYHQECRGGNFSALAKLKERIVACGANYGVFHASNGQVLREQF 389

Human   416 GTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTRFQEVFRSMWSVNGDSISKIYA 480
            |.|||||||||||||.||.:|||:.|..|||||.:..|.|.::||:|:||.||..||:.:|||||
  Fly   390 GVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFEEIFRQMWINNGNEVSKIYA 454

Human   481 GTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSE 545
            ||||::|.:||.|||||..||||||..|:||||||||||:|:||:|:|||:||.||.:..|.
  Fly   455 GTGAIQGGSKLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNMLH--- 516

Human   546 QTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGI 610
                 |.:.||:.:|:.:.:|.:|:..||.|||:||||||.||||.||: :|.|||||...||..
  Fly   517 -----APTTVLRELCKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKD-SLADWLLDCHALARS 575

Human   611 QEFQDKRS------KPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLAS 669
            :...|..:      .|.||:||||||:|:|||.||::|||.|.||||.||||||||||.||||..
  Fly   576 KALVDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTISRDNDYVLLTY 640

Human   670 EQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQS 734
            :|||||||:::|||:|||.|||||:|.||||:|||||||||.|||.:.|.||:||||:|||||||
  Fly   641 QQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQS 705

Human   735 QVKERNEDFIEIARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQL 799
            ||.|||.|:.||.|||:|||||.|.|||:||||||||||||:..:|:||.:|..:..:::..|||
  Fly   706 QVAERNADYAEITRKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKDELKECVRNGDLSTVLEFDQL 770

Human   800 INQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLD 864
            ..::.||.||..||||::||.|||||||||||||||||.|.|||||||||||||          .
  Fly   771 RKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRK----------A 825

Human   865 LLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQG 929
            |....|...:     |.||.|:||||:|||.||||||:|:||.:|.|::.:.|:.::::||...|
  Fly   826 LAEGDFAASA-----WNPGKLIHYGRSELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIRDLG 885

Human   930 PPDGTVLVSIKSSLPENN-----FFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALN 989
            |||.|::|.:..|....:     .:|:.::..|:.:.:..|||.|:|:|||.|||||.:|.||||
  Fly   886 PPDSTIVVHVLESSATGDEDGPTIYDENVMSALITELSKMGEVTLVRYVEDTMWVTFRDGESALN 950

Human   990 VLSLNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDV 1054
            ..|....::....:.:.|||.||...::.|:.|         .|::|:
  Fly   951 ASSKKSIQVCGLDLILELKSKDWQHLVDSEIEL---------CTTNTI----------------- 989

Human  1055 DDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS 1119
                                      |..:   :|.:...:.:...|.||.||.:.|:|.|..|.
  Fly   990 --------------------------PLCA---NPVEHAQLLQAITPELPQRPKQPPTRPPARPP 1025

Human  1120 AQSSPIDAQPATP-------LPQKDPAQPLEPKRPPPPRPVAPPTRPAP--PQRPPPPSGARSPA 1175
            ...||.::....|       :|:  ||:|     |.||:|.:.|..|:|  ||..||...|....
  Fly  1026 MPMSPKNSPRHLPHVGVISIVPK--PAKP-----PMPPQPQSQPLIPSPLQPQVAPPRPPAMDTT 1083

Human  1176 PTRKEFGGIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPR 1240
            |:.|.       .||      .|...:..:|  .:.|::.|:..|.|:||         || |||
  Fly  1084 PSSKS-------QSP------TELVSASSST--SSSGKTSPTAPAVLSGP---------PT-PPR 1123

Human  1241 AGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSL------------- 1292
                   |..::.:....||..|..:.:         :|:....|:...|::
  Fly  1124 -------QMQSKQATPVSTPTRQVGSPK---------DPIPSDTAYETASNIYEEIQEDVPAPRH 1172

Human  1293 PPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASS 1341
            ||||    .|...:.|||....|.||...||..|.||.::..||:..::
  Fly  1173 PPPA----GPPPVIGAPMGPPPPLPNRRGPPPIPNRSGNAPPLPTRPAN 1217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SYNJ1	NP_003886.3	Syja_N	99..379	CDD:280532	175/292 (60%)
		INPP5c_Synj1	572..907	CDD:197332	213/340 (63%)
		DUF1866	906..1047	CDD:286093	43/145 (30%)
Synj	NP_001246454.1	Syja_N	61..353	CDD:280532	175/292 (60%)
		INPP5c_Synj	538..863	CDD:197323	213/340 (63%)
		DUF1866	862..1008	CDD:286093	45/200 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146097
Domainoid	1	1.000	409	1.000	Domainoid score	I694
eggNOG	1	0.900	-	-		E1_COG5411
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48252
Inparanoid	1	1.050	1110	1.000	Inparanoid score	I229
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48338
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	1	1.000	-	-		FOG0002172
OrthoInspector	1	1.000	-	-		otm41819
orthoMCL	1	0.900	-	-		OOG6_101787
Panther	1	1.100	-	-	LDO	PTHR11200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1445
SonicParanoid	1	1.000	-	-		X1883
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800