DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PER2 and per

DIOPT Version :10

Sequence 1:NP_073728.1 Gene:PER2 / 8864 HGNCID:8846 Length:1255 Species:Homo sapiens
Sequence 2:NP_525056.2 Gene:per / 31251 FlyBaseID:FBgn0003068 Length:1218 Species:Drosophila melanogaster


Alignment Length:1361 Identity:280/1361 - (20%)
Similarity:463/1361 - (34%) Gaps:427/1361 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    37 GSSGHETNENCSTGRDSQGSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSDQ 101
            |....|:..|......:..:.|.:|           .:::|..:.|.:  ...|:..:||.....
  Fly     3 GGESTESTHNTKVSDSAYSNSCSNS-----------QSQRSGSSKSRL--SGSHSSGSSGYGGKP 54

Human   102 SSKVDTHKELIKTLKELKVHLPADKKAK--------GKASTLATLKYAL---------------- 142
            |::..:...:||..|:     .:.||.|        |:|.||.:...:|                
  Fly    55 STQASSSDMIIKRNKD-----KSRKKKKNKGAGQGAGQAQTLISASTSLEGRDEEKPRPSGTGCV 114

Human   143 --------------------RSVKQVKANEEYYQLLMSSE------------------------- 162
                                ::::|::..||..|....||                         
  Fly   115 EQQICRELQDQQHGEDHSEPQAIEQLQQEEEEDQSGSESEADRVEGVAKSEAAQSFPIPSPLSVT 179

Human   163 ------------GHPCGADVPSYTVE--------EMESVT------------SEHIVKNADMFAV 195
                        ||..|.|......:        ::||:|            .|.:  ..|.|..
  Fly   180 IVPPSMGGCGGVGHAAGLDSGLAKFDKTWEAGPGKLESMTGVGAAAAGTGQRGERV--KEDSFCC 242

Human   196 AVSLVSGKILYISDQVASIFHCKRDAFSDAKFVEFLAPHDVGVFHSFTSPYKLPLWSMCSGADSF 260
            .:|:..|.:||.:..:..:....||.:....|::|:...|...|.|..:. .:|:      |:|.
  Fly   243 VISMHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITT-GIPI------AESR 300

Human   261 TQECMEEKSFFCRVSVRKSH----------ENEIRYHPFRM------TP-------YLVKVRDQQ 302
            .....:.||.|| |.:|:..          ...:.|.|||:      .|       |:|    ..
  Fly   301 GSVPKDAKSTFC-VMLRRYRGLKSGGFGVIGRPVSYEPFRLGLTFREAPEEARPDNYMV----SN 360

Human   303 GAESQLCCLLLAERVHSGYEAPR--IPPEKRIFTTTHTPNCLFQDVDERAVPLLGYLPQDLIETP 365
            |  :.:..::.|..:.|.|:.|.  :..:...|...||...:...||..||..|||||||||...
  Fly   361 G--TNMLLVICATPIKSSYKVPDEILSQKSPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRS 423

Human   366 VLVQLHPSDRPLMLAIHKKILQSG---GQPFDYSPIRFRARNGEYITLDTSWSSFINPWSRKISF 427
            ::...|..|..:|...::.:::.|   |..|...|.||..:||.|:.|:|.|:||:||||||:.|
  Fly   424 IMDFYHHEDLSVMKETYETVMKKGQTAGASFCSKPYRFLIQNGCYVLLETEWTSFVNPWSRKLEF 488

Human   428 IIGRHKVRVGPLNEDVFAAHP-C-----TEEKALHPSIQE-LTEQIHRLLLQP---VPHSGSSGY 482
            ::|.|:|..||...:||.|.| |     .|.::.:..|:| :.:::...:.:|   |....|...
  Fly   489 VVGHHRVFQGPKQCNVFEAAPTCKLKISEEAQSRNTRIKEDIVKRLAETVSRPSDTVKQEVSRRC 553

Human   483 GSLGSNGSHEHLMSQTSSSDSN---GHED----SRRRRAEICKNGNKTKNRSHYSHESGEQKKKS 540
            .:|.|  ..|.||.:.|.:|..   .||:    |.|....:   |..:.:..:|.       .||
  Fly   554 QALAS--FMETLMDEVSRADLKLELPHENELTVSERDSVML---GEISPHHDYYD-------SKS 606

Human   541 VTEMQTNPPAEKKAVPAMEKDSLGVSFPEELACKNQPTCSYQQISCLDSVIRYLESCNEAATLKR 605
            .||   .||                              ||.|::..::::|:..|        :
  Fly   607 STE---TPP------------------------------SYNQLNYNENLLRFFNS--------K 630

Human   606 KCEFPANV--PALRSSDKRKATVS--PGP----HAGEAEPPSRVNSRTGVGTHLTSLAL------ 656
            ....||.:  |.....:.|...||  .||    |.|.....|..|..|....|::|:..      
  Fly   631 PVTAPAELDPPKTEPPEPRGTCVSGASGPMSPVHEGSGGSGSSGNFTTASNIHMSSVTNTSIAGT 695

Human   657 ------------------PGKAESVASLTSQCSYSSTIVHVGDKKPQPELEMVEDAASGPESLDC 703
                              .|......:.|...:.:.|....|:.         .::.:|..:...
  Fly   696 GGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGNG---------TNSGTGTGTASS 751

Human   704 LAGPALACGLSQEKEPFKKLGLTKEVLAAHTQKEEQSFLQKFKEIRKLSIFQSHCHYYLQERSKG 768
            ..|.:.|         ...:.||:.:|..|..:.|:..|:|.:|.|..:          .|:||.
  Fly   752 SKGGSAA---------IPPVTLTESLLNKHNDEMEKFMLKKHRESRGRT----------GEKSKK 797

Human   769 QPS------ERTAPGLRNTSGIDSPWKKTGKNRKLKSKRVKPRDSSE--------STGSGGPVSA 819
            ..:      |.:.||.....|....|:  |:..|.|.:.....|:.:        :.|:||..|.
  Fly   798 SANDTLKMLEYSGPGHGIKRGGSHSWE--GEANKPKQQLTLGTDAIKGAAGSAGGAVGTGGVGSG 860

Human   820 RPPLVGLNAT----AWSP----SDTSQSSCP-------------------AVPFPAPVPAAY--- 854
            ...:.|...:    |.:|    :.||.:..|                   :|....|.|::|   
  Fly   861 GAGVAGGGGSGTGVAGTPEGRATTTSGTGTPGGAGGGGGAGAAAAAGASSSVGSSTPGPSSYPTC 925

Human   855 --SLPVFPAPGTVAAPPAPPHASFTVPAVPVDLQHQFAVQP--PPF---PAPLAPVMAFMLP--- 909
              ::.::| |.:|...| |.|::.|..|     |..|:...  |.|   ||.|.|......|   
  Fly   926 TQNINLWP-PFSVGITP-PVHSTHTAMA-----QSSFSSAGLFPTFYYIPASLTPTSPTRSPRMH 983

Human   910 SYSFPSGT--PNLPQ-----------------AFFPSQPQFPSHPTLTSEMASASQP-EFPSRTS 954
            .:....||  |...|                 ..:|....|.:||...:..|...|| .||...:
  Fly   984 KHPHKGGTDMPTTSQQAAAAAAQAMPLQYMAGVMYPHPSLFYTHPAAAAATAMMYQPMPFPGMAN 1048

Human   955 ---IPRQPCAC-----PATRATPPSAMGRASPPLFQSRSSSPLQLNLLQLEEAPEGGTGAMGTTG 1011
               ||.:|...     .:...|.|::|.:..|..|.| .::|.|:      :.|...:.::.|..
  Fly  1049 ALQIPERPLGSQSAYNKSVYTTTPASMTKKVPGAFHS-VTTPAQV------QRPSSQSASVKTEP 1106

Human  1012 ATETAAVGADCKPGTSRDQQPKAPLTRDEPSDTQNSDALSTSSGLLNLLLNEDLCSASGSAASES 1076
            .: :|||...||.... |..|...:..|     .|||...:||...|   |:....::|:     
  Fly  1107 GS-SAAVSDPCKKEVP-DSSPIPSVMGD-----YNSDPPCSSSNPAN---NKKYTDSNGN----- 1156

Human  1077 LGSGSLGCDASPSGAGSSDTSHTSKYFGSIDSSEN--------NHKAKMNTGMEES---EH 1126
                      |....|||.:|..|.:..:.|.||:        .|:...:....||   ||
  Fly  1157 ----------SDDMDGSSFSSFYSSFIKTTDGSESPPDTEKDPKHRKLKSMSTSESKIMEH 1207

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PER2NP_073728.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..79 6/41 (15%)
Nuclear export signal 1. /evidence=ECO:0000250|UniProtKB:O54943 111..120 3/8 (38%)
LXXLL 308..312 0/3 (0%)
PAS_3 346..430 CDD:430001 37/86 (43%)
Nuclear export signal 2. /evidence=ECO:0000250|UniProtKB:O54943 462..471 0/8 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 473..557 22/93 (24%)
Important for protein stability. /evidence=ECO:0000250|UniProtKB:Q9Z301 480..484 0/3 (0%)
CSNK1E binding domain. /evidence=ECO:0000250|UniProtKB:O54943 512..717 35/236 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 617..646 9/34 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 764..838 20/95 (21%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O54943 789..805 3/15 (20%)
Interaction with PPARG. /evidence=ECO:0000250|UniProtKB:O54943 888..1071 49/218 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..985 17/62 (27%)
Nuclear export signal 3. /evidence=ECO:0000250|UniProtKB:O54943 989..996 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1018..1050 9/31 (29%)
Period_C 1046..1208 CDD:463464 22/92 (24%)
LXXLL 1057..1061 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1077..1106 6/28 (21%)
CRY binding domain. /evidence=ECO:0000250|UniProtKB:Q9Z301 1155..1255
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1231..1255
perNP_525056.2 PAS 238..333 CDD:395786 22/102 (22%)
PAS 388..495 CDD:238075 42/106 (40%)
Blue background indicates that the domain is not in the aligned region.

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