Protein Alignment PER3 and cyc

DIOPT Version :9

• Sequence 1: NP_001276791.1
• Gene: PER3 / 8863
• HGNCID: 8847
• Length: 1210
• Species: Homo sapiens
• Sequence 2: NP_524168.2
• Gene: cyc / 40162
• FlyBaseID: FBgn0023094
• Length: 413
• Species: Drosophila melanogaster
• Alignment Length: 426
• Identity: 101/426 - (23%)
• Similarity: 172/426 - (40%)
• Gaps: 91/426 - (21%)

Human    15 KDEALGEESGERWSPEFHLQRKLADSSHSEQQDRNRVSEELIMVVQEMKKYFPS--ERRNKPSTL 77
            :||...||...|.|.|   .||   .:|||.:.|.|  :::...:.|:....|.  ..:.|...|
  Fly    14 EDENYDEEKSARTSDE---NRK---QNHSEIEKRRR--DKMNTYINELSSMIPMCFAMQRKLDKL 70

Human    78 DALNYALRCVHSVQANSEFFQILSQNGAPQADVSMYSLEELATI---ASEHTSKNTDTFVAVFSF 139
            ..|..|::.:..::.:.........:..|    |..|.:||..|   |||       .|:.|...
  Fly    71 TVLRMAVQHLRGIRGSGSLHPFNGSDYRP----SFLSDQELKMIILQASE-------GFLFVVGC 124

Human   140 LSGRLVHISEQAALILN-RKKDVLASSHFVDLLAPQDM-RVFYAHTARAQLPFWNNWTQRAAARY 202
            ..||::::|:..:.:|| .:.|:|..|.| |:|.|:|: :|....::..|.|     .:|.....
  Fly   125 DRGRILYVSDSVSSVLNSTQADLLGQSWF-DVLHPKDIGKVKEQLSSLEQCP-----RERLIDAK 183

Human   203 ECAPVK----------------PFFCRIR---------------GGEDRKQEKCHS------PFR 230
            ...|||                .||||::               ....|...|..|      .:|
  Fly   184 TMLPVKTDVPQSLCRLCPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYR 248

Human   231 II----------PYLIHVHHPAQPELESEPCCLTVVEKIHSGYEAPRIP--------VNKRIFTT 277
            :|          |...........|..:...||..:.:|........:|        :...:|.:
  Fly   249 VIQCTGYLKSWTPIKDEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFIS 313

Human   278 THTPGCVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPI- 341
            .|:....||.:|::|..::|:|||:::|||...|.|.||.:.::..|:.|::.   |....:.:
  Fly   314 RHSGEGKFLFIDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQV---PEKVTTQVY 375

Human   342 RFCTQNGDYIILDSSWSSFVNPWSRKISFIIGRHKV 377
            ||..::..||.|.|.|.:|.|||:.:|.:||.::.|
  Fly   376 RFRCKDNSYIQLQSEWRAFKNPWTSEIDYIIAKNSV 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PER3	NP_001276791.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		13/34 (38%)
		Nuclear export signal 1. /evidence=ECO:0000250	55..64		1/8 (13%)
		PAS	285..377	CDD:238075	32/92 (35%)
		Nuclear export signal 3. /evidence=ECO:0000250	404..413
		CSNK1E binding domain. /evidence=ECO:0000250	563..768
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	725..796
		Nuclear localization signal. /evidence=ECO:0000250	737..753
		Herpes_BLLF1	<756..1066	CDD:282904
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	889..931
		Nuclear export signal 2. /evidence=ECO:0000250	933..940
		5 X 18 AA tandem repeats of S-[HP]-[AP]-T-[AT]-[GST]-[ATV]-L-S-[MT]-G-[LS]-P-P-[MRS]- [EKR]-[NST]-P	974..1063
		Period_C	<1083..1198	CDD:403366
		CRY binding domain. /evidence=ECO:0000250	1132..1210
cyc	NP_524168.2	HLH	31..84	CDD:278439	13/57 (23%)
		PAS	111..212	CDD:279347	29/113 (26%)
		PAS	111..173	CDD:214512	19/69 (28%)
		PAS_11	311..411	CDD:291273	34/102 (33%)
		PAS	311..406	CDD:238075	32/97 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331262at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920