DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCKAR and CCKLR-17D3

DIOPT Version :9

Sequence 1:	NP_000721.1	Gene:	CCKAR / 886	HGNCID:	1570	Length:	428	Species:	Homo sapiens
Sequence 2:	NP_001097023.1	Gene:	CCKLR-17D3 / 32864	FlyBaseID:	FBgn0030954	Length:	584	Species:	Drosophila melanogaster

Alignment Length:	479	Identity:	166/479 - (34%)
Similarity:	237/479 - (49%)	Gaps:	71/479 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    15 TPPCELGLENETLFCL---DQPRPS---------KEWQPAVQILLYSLIFLLSVLGNTLVITVLI 67
            |.|.:  |..|..|.|   ..|.||         ....|...|..||:|.|.:||||.|||:.|:
  Fly    75 TEPSD--LVTELAFSLGTSSSPSPSSTPASSSSTSTGMPVWLIPSYSMILLFAVLGNLLVISTLV 137

Human    68 RNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNL 132
            :|:||||:||:|||:||:||::|.:.|||..|:..||::||||..:||...:....||:||::.|
  Fly   138 QNRRMRTITNVFLLNLAISDMLLGVLCMPVTLVGTLLRNFIFGEFLCKLFQFSQAASVAVSSWTL 202

Human   133 VAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCR 197
            ||||.|||.|||.||:||.|||.|||.|:|...|......|||..::|.|:|.::..   ...||
  Fly   203 VAISCERYYAICHPLRSRSWQTISHAYKIIGFIWLGGILCMTPIAVFSQLIPTSRPG---YCKCR 264

Human   198 FLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQ-----------KKSAK 251
            ...|:...:..::..|..:|.::|.:|:.|||.||:..||.|:..::.:           .....
  Fly   265 EFWPDQGYELFYNILLDFLLLVLPLLVLCVAYILITRTLYVGMAKDSGRILQQSLPVSATTAGGS 329

Human   252 ERKPSTTSS---------------------GKYEDSDG-------CYLQKTRPPRKLELRQLST- 287
            ...|.|:||                     |..|.|.|       .....|||.....:...:|
  Fly   330 APNPGTSSSSNCILVLTATAVYNENSNNNNGNSEGSAGGGSTNMATTTLTTRPTAPTVITTTTTT 394

Human   288 -----GSSSRANRI-----RSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTAS 342
                 .:||.:.|:     |.::.|..|.:||||::||.|:|:.||:||.|::..|.........
  Fly   395 TVTLAKTSSPSIRVHDAALRRSNEAKTLESKKRVVKMLFVLVLEFFICWTPLYVINTMVMLIGPV 459

Human   343 AERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGG 407
            ....:..|.|||:.||:|:|||.|||.|||||..||..|:.||...|.....||.|.||....||
  Fly   460 VYEYVDYTAISFLQLLAYSSSCCNPITYCFMNASFRRAFVDTFKGLPWRRGAGASGGVGGAAGGG 524

Human   408 TT----GASLSRFSYSHMSASVPP 427
            .:    ||....::.::.:.|:.|
  Fly   525 LSASQAGAGPGAYASANTNISLNP 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCKAR	NP_000721.1	CholecysA-Rec_N	1..47	CDD:286302	11/43 (26%)
		7tm_4	48..>196	CDD:304433	73/147 (50%)
		7tm_1	58..370	CDD:278431	127/361 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..272		8/51 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..428		11/38 (29%)
CCKLR-17D3	NP_001097023.1	7tm_4	120..>244	CDD:304433	65/123 (53%)
CCKLR-17D3	NP_001097023.1	7tm_1	128..487	CDD:278431	127/361 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147360
Domainoid	1	1.000	227	1.000	Domainoid score	I2509
eggNOG	1	0.900	-	-		E33208_3BDYY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3167
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1042780at2759
OrthoFinder	1	1.000	-	-		FOG0001992
OrthoInspector	1	1.000	-	-		otm42082
orthoMCL	1	0.900	-	-		OOG6_105354
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1306
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.660