Protein Alignment CCKAR and Cckar

DIOPT Version :10

• Sequence 1: NP_000721.1
• Gene: CCKAR / 886
• HGNCID: 1570
• Length: 428
• Species: Homo sapiens
• Sequence 2: NP_036820.1
• Gene: Cckar / 24889
• RGDID: 2289
• Length: 444
• Species: Rattus norvegicus
• Alignment Length: 428
• Identity: 392/428 - (91%)
• Similarity: 411/428 - (96%)
• Gaps: 1/428 - (0%)

Human     1 MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITV 65
            ||||||||:||||||||||||||||||||||||:||||||.|:||||||:|||||||||||||||
  Rat    16 MDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITV 80

Human    66 LIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTF 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    81 LIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTF 145

Human   131 NLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANM 195
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   146 NLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANM 210

Human   196 CRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSS 260
            ||||||:|.|||||.|||||||||:|||||:||||||||||||||||:|||||||||:||||.||
  Rat   211 CRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSS 275

Human   261 GKYEDSDGCYLQKTRPPRKLELRQLSTGS-SSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFL 324
            .:|||||||||||:||||||||:|||:|| .||.|||||:||||||:||||||||||||||||||
  Rat   276 TRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFL 340

Human   325 CWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCP 389
            ||||||||||||||||.|||:.|||||||||||||||||||||||||||||||||||||||||||
  Rat   341 CWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCP 405

Human   390 NPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPP 427
            ||||||.||||||||:|.|..|.|||:||||||.|.||
  Rat   406 NPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPP 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKAR	NP_000721.1	CholecysA-Rec_N	1..47	CDD:462713	41/45 (91%)
		7tm_GPCRs	42..381	CDD:475119	315/339 (93%)
		TM helix 1	44..68	CDD:410628	22/23 (96%)
		TM helix 2	77..99	CDD:410628	21/21 (100%)
		TM helix 3	115..137	CDD:410628	21/21 (100%)
		TM helix 4	160..176	CDD:410628	15/15 (100%)
		TM helix 5	207..230	CDD:410628	19/22 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	248..272		19/23 (83%)
		TM helix 6	312..334	CDD:410628	21/21 (100%)
		TM helix 7	349..374	CDD:410628	24/24 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..428		25/34 (74%)
Cckar	NP_036820.1	CholecysA-Rec_N	16..62	CDD:462713	41/45 (91%)
		7tm_GPCRs	57..397	CDD:475119	315/339 (93%)
		TM helix 1	59..83	CDD:410628	22/23 (96%)
		TM helix 2	92..114	CDD:410628	21/21 (100%)
		TM helix 3	130..152	CDD:410628	21/21 (100%)
		TM helix 4	175..191	CDD:410628	15/15 (100%)
		TM helix 5	222..245	CDD:410628	19/22 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	263..288		20/24 (83%)
		TM helix 6	328..350	CDD:410628	21/21 (100%)
		TM helix 7	365..390	CDD:410628	24/24 (100%)