Protein Alignment CCKAR and ckr-1

DIOPT Version :10

• Sequence 1: NP_000721.1
• Gene: CCKAR / 886
• HGNCID: 1570
• Length: 428
• Species: Homo sapiens
• Sequence 2: NP_491918.3
• Gene: ckr-1 / 188774
• WormBaseID: WBGene00020712
• Length: 421
• Species: Caenorhabditis elegans
• Alignment Length: 394
• Identity: 126/394 - (31%)
• Similarity: 194/394 - (49%)
• Gaps: 66/394 - (16%)

Human    47 LYSLIFLLSVLGNTLVI-TVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFG 110
            ::.|..:||:|||.:|| |:|.::.|.|::||.:||:||.:||:..:.|:|..|:..|.:.::.|
 Worm    19 IFLLCLILSLLGNAIVILTILGKSHRSRSITNFYLLNLAFADLLRSIICIPSTLLGELTQCWLLG 83

Human   111 SAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTI-MT 174
            :|:||...:.....|..|.:.|..|::|||.|||:||:||.||||..||..|:..||.||:. :|
 Worm    84 AAMCKIVAFLQPVGVCASAYTLAVIAIERYYAICRPLESRKWQTKKRALITISLVWCFSFSANLT 148

Human   175 PYPIYSNLVPFTKNNNQTANMCRFLLPN------DVMQQSWHTFLLLILFLIPGIVMMVAYGLIS 233
            ...:|.            ||..:|...:      |.:.|.:.||.||   .:|..:|:..||.:.
 Worm   149 SLFLYD------------ANPGKFTCDSTKGPLVDFIYQLYLTFTLL---FVPLALMVGLYGNVI 198

Human   234 LELYQGIKFE---ASQKK----------------SAKERKPS---TTSSGKYEDSDGCYLQKT-- 274
            :.|...|..:   ..|:.                ||.:|.||   .:.:.::::.:...:.:|
 Worm   199 ITLNTAINSDHPTVEQQMIEKTLPSRASFSDWFVSAVQRVPSMKVVSKTFQFKEKNSLSIPQTSG 263

Human   275 ---RPPRKLELRQLST--GSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANA 334
               ||.|.......||  ||......:||.:....|:|||:|.||||.:|::|..||:|  |...
 Worm   264 LSVRPSRSSFSSFFSTPRGSFDVTMLLRSTNQEKILIAKKKVTRMLITLVIVFAFCWVP--SYLY 326

Human   335 WRAYDTASAERRLSGTPI------SFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGP 393
            |.....|    .|:.|.:      |.:.:::|.||..|||.||||||.||...:|.  |.|.|..
 Worm   327 WLLLRMA----ELAATDLWNPGLNSSLTIMTYISSLANPITYCFMNKSFRSSVLAY--CRPKPKR 385

Human   394 PGAR 397
            |..|
 Worm   386 PLTR 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCKAR	NP_000721.1	CholecysA-Rec_N	1..47	CDD:462713	126/394 (32%)
		7tm_GPCRs	42..381	CDD:475119	120/376 (32%)
		TM helix 1	44..68	CDD:410628	10/21 (48%)
		TM helix 2	77..99	CDD:410628	9/21 (43%)
		TM helix 3	115..137	CDD:410628	5/21 (24%)
		TM helix 4	160..176	CDD:410628	6/16 (38%)
		TM helix 5	207..230	CDD:410628	7/22 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	248..272		5/42 (12%)
		TM helix 6	312..334	CDD:410628	10/21 (48%)
		TM helix 7	349..374	CDD:410628	11/30 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..428		2/4 (50%)
ckr-1	NP_491918.3	7tmA_CCKR-like	30..375	CDD:320124	116/365 (32%)
		TM helix 2	49..75	CDD:320124	11/25 (44%)
		TM helix 3	87..117	CDD:320124	10/29 (34%)
		TM helix 4	131..149	CDD:320124	7/17 (41%)
		TM helix 5	171..196	CDD:320124	9/27 (33%)
		TM helix 6	300..330	CDD:320124	15/31 (48%)
		TM helix 7	343..368	CDD:320124	10/24 (42%)