DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NR1I2 and EcR

DIOPT Version :9

Sequence 1:	NP_071285.1	Gene:	NR1I2 / 8856	HGNCID:	7968	Length:	473	Species:	Homo sapiens
Sequence 2:	NP_001163061.1	Gene:	EcR / 35540	FlyBaseID:	FBgn0000546	Length:	878	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	136/497 - (27%)
Similarity:	225/497 - (45%)	Gaps:	93/497 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    28 LASNH-PRGPEANL------EVRPKESWN-HADFVHCEDTESVPGKPSVNADEEVGGPQICRVCG 84
            |...| ||....|.      ::.|..|.| ::....|:..:|..| |:....||     :|.|||
  Fly   210 LGMQHTPRSDSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKG-PAPRVQEE-----LCLVCG 268

Human    85 DKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKE 149
            |:|:|||:|.:|||||||||||::.::|...|.|.: |||:....||:||.|||:|||..||:.|
  Fly   269 DRASGYHYNALTCEGCKGFFRRSVTKSAVYCCKFGR-ACEMDMYMRRKCQECRLKKCLAVGMRPE 332

Human   150 MIM-SDEAVEERRALIKRKKSERTGTQPLGVQGLTEE------QRMMIRELMDAQMKTFDTTFSH 207
            .:: .::...:||....:|:.::..|.|....|....      |..:.:|::|...
  Fly   333 CVVPENQCAMKRREKKAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMT--------- 388

Human   208 FKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVW---NYKPPAD 269
                         ||.|:....|...:........:::.||..: ||......:|   .|:.|::
  Fly   389 -------------CEPPQHATIPLLPDEILAKCQARNIPSLTYN-QLAVIYKLIWYQDGYEQPSE 439

Human   270 SGGKEIFS-----------LLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELC 323
            ...:.|.|           ...|:.:::....:.|:.|||.:..|..:|.||||:|||..:.|:.
  Fly   440 EDLRRIMSQPDENESQTDVSFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVM 504

Human   324 QLRF--------NTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYV 380
            .||.        :::|.|...::.  |.||.:...|..     :|.:|.|...:..:::...||.
  Fly   505 MLRMARRYDHSSDSIFFANNRSYT--RDSYKMAGMADN-----IEDLLHFCRQMFSMKVDNVEYA 562

Human   381 LMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNR--PQPAHRFLFLKIMAMLTELRSIN 443
            |:.||.:|| ||||:.:.::|:.:|..:..||:.|| .||  ........:.|::::|||||::.
  Fly   563 LLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYI-LNRHCGDSMSLVFYAKLLSILTELRTLG 625

Human   444 AQHTQR--------------LLRIQDIHPFATPLMQELFGIT 471
            .|:.:.              |..|.|:|.. .|.:|....||
  Fly   626 NQNAEMCFSLKLKNRKLPKFLEEIWDVHAI-PPSVQSHLQIT 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NR1I2	NP_071285.1	NR_DBD_PXR	79..166	CDD:143536	42/87 (48%)
NR1I2	NP_071285.1	NR_LBD_PXR_like	182..467	CDD:132732	74/328 (23%)
EcR	NP_001163061.1	NR_DBD_EcR	261..351	CDD:143535	44/95 (46%)
EcR	NP_001163061.1	NR_LBD_EcR	420..652	CDD:132736	61/240 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157580
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940