Protein Alignment KAT2B and pcaf-1

DIOPT Version :10

• Sequence 1: NP_003875.3
• Gene: KAT2B / 8850
• HGNCID: 8638
• Length: 832
• Species: Homo sapiens
• Sequence 2: NP_491173.1
• Gene: pcaf-1 / 171920
• WormBaseID: WBGene00021636
• Length: 767
• Species: Caenorhabditis elegans
• Alignment Length: 793
• Identity: 259/793 - (32%)
• Similarity: 399/793 - (50%)
• Gaps: 109/793 - (13%)

Human    89 KKLEKLGVYSACKAEESCKCNGWK---NPNPSPTPPRA--------------DLQQIIVSLTESC 136
            :|..:|..:::|.| .:|:|.|::   |........||              ||:.:.......|
 Worm     9 EKRRQLTYFTSCNA-GTCQCRGFRPVLNHEDETVERRATRAERENDFAPMTRDLETLGSEEIIEC 72

Human   137 RSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDAD----TKQVYFYLFKLLRKS 197
            |:|.|:::.|...|:.:|:|:::.....:.|::   ||..:..:.|    :.|..:...::|.||
 Worm    73 RTCGHSISFHAEPLKYLSQEDLDTYTDQISDLQ---TCCSELSEIDPSHESLQTLYITMQILLKS 134

Human   198 ILQRGKPVVEGSLEKKPPFEKPSIEQG--VNNFVQYKFSHLPAKERQTIVELAKMFLNRINYWHL 260
            :  |....|:.....||.||..|:...  |..|:..:  .:...|:|.:.|:..:||..:|:|.|
 Worm   135 L--RTLTPVDVPFIGKPNFEPESLSPYILVKKFIASR--PVDNAEKQRLAEIGTLFLTEMNHWKL 195

Human   261 EA--PSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTQVFGR----TLLRSVFTVM 319
            |.  ....:|..|.:. ..|:..|.|...|.|:|....|..:::|..:||.    |....:..|:
 Worm   196 EGFQSLADKLNVPLEQ-GKYRMMYVRMDYYVNMPAKYVSFKQFQTVDIFGEKFTTTFCNYLINVL 259

Human   320 R----------RQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQNSPIWDQDFLSASS 374
            .          ...||:..::......:.|..:.|..|:..|                   :.:.
 Worm   260 NTGNYTPFGLSESDLEENSEDLITFATDLRRYLETEDPQSTS-------------------TTNR 305

Human   375 RTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSGLEANPGEKRKMTDSHVLEE 439
            |...:..:.||        :.|.......:  ::.||||...::|.:| .|..::|...|    .
 Worm   306 RKDSISTEDVI--------LKYVKRKKPTD--HSESSSPRELSTSPVE-EPRRRKKEPSS----S 355

Human   440 AKK-PRVMGDIPMELINEVMSTIT---DPAAMLGPETNF----LSAHSARDEAARLEERRGVIEF 496
            ||| |..  :..|.|:..::..|.   |..|| .|:|..    |:...:|..:|..||..|:|||
 Worm   356 AKKSPET--EESMALLRSLIRAIKFEGDLDAM-EPKTKVEFEALNTEVSRGLSALQEEESGLIEF 417

Human   497 HVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALIK-DGRVIGGICF 560
            .|:||.|:...:.:.|:.||.|||:|..|||:|||||:|||:||.:|:.:.::| |..|||||||
 Worm   418 RVIGNDLDPFQHHEQLVHLVELQNLFGAQLPKMPKEYVTRLIFDSRHQNMVILKRDMGVIGGICF 482

Human   561 RMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKE 625
            |.|||:||.||||||:|:.|||||||||||||.|:|.||:.|.:.||||||:|||||.|||||::
 Worm   483 RTFPSRGFVEIVFCAITAMEQVKGYGTHLMNHCKDYMIKNKIYHMLTYADEFAIGYFTKQGFSEK 547

Human   626 IKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIR-KVYPGLS 689
            ::|..|.|.|:||:|||||||||.|:|:|.||:|....|..:.:.........|:.| ||:.||.
 Worm   548 LEINDTVYQGWIKEYEGATLMGCHLHPQISYTKFPDFSKGIQALHCGYKSENGAESRGKVFGGLE 612

Human   690 -CFKDGVRQ-IPIESIPGIRETGWKPSGKEKSK-----EPRDPDQLYSTLKSILQQVKSHQSAWP 747
             .|::...| :.:..:||      ..|.|...|     :.|| |.|.|.:.:||:::.:.::|||
 Worm   613 HLFRESSPQLLELRKVPG------TDSLKMHKKSCYHLDERD-DSLDSKIGAILKKLTADKNAWP 670

Human   748 FMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKC 812
            |..||...|.|.||:.|:.|:|.|||.|:||.:.|..:.||:|||.|:|.||..:|..|:.|||.
 Worm   671 FASPVDVKEVPEYYDHIKHPIDFKTMQEKLKRKAYTHQHLFIADLNRLFQNCYVFNGAEAVYYKY 735

Human   813 ANILEKFFFSKIK 825
            ...|.:.....:|
 Worm   736 GYKLNELALKLLK 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KAT2B	NP_003875.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54
		PCAF_N	74..325	CDD:461923	60/274 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	395..436		10/40 (25%)
		COG5076	487..826	CDD:227408	165/348 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	706..725		4/23 (17%)
		Bromo_gcn5_like	727..826	CDD:99941	40/99 (40%)
pcaf-1	NP_491173.1	PCAF_N	6..247	CDD:461923	58/246 (24%)
		COG5076	408..735	CDD:227408	162/333 (49%)
		Bromo_gcn5_like	650..748	CDD:99941	39/97 (40%)