DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TSC22D1 and bun

DIOPT Version :9

Sequence 1:	NP_904358.2	Gene:	TSC22D1 / 8848	HGNCID:	16826	Length:	1073	Species:	Homo sapiens
Sequence 2:	NP_001036357.2	Gene:	bun / 34665	FlyBaseID:	FBgn0259176	Length:	1331	Species:	Drosophila melanogaster

Alignment Length:	1368	Identity:	334/1368 - (24%)
Similarity:	487/1368 - (35%)	Gaps:	440/1368 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    19 ARKMAHPAMFP-RRGSGSGSASALNAAGTGVG-------SNATSSEDFP---PPSLLQPPPPAAS 72
            |...|.|...| ||.|....:..:...|||..       |:.||:..|.   |||.:......|.
  Fly    13 ASSNAGPGNNPVRRNSMLTPSRGVTIGGTGGNIRKLTKVSSLTSNHHFAVCYPPSNIYQNSNNAG 77

Human    73 STSGPQPPPPQS--LNLLSQAQLQAQPLAPGGTQMKKKSGFQI-----TSVTPAQISASISSNNS 130
            |.|..|....:|  ||::|:....|.|.    |..:..|...:     ||:.|...|:|..||::
  Fly    78 SNSALQRTTSESLRLNMMSRVAAGATPT----TVSRASSNSSLATSTSTSLAPKSSSSSGGSNST 138

Human   131 IAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETP--------- 186
                       .:...:.|.||                 .:||..:.|:|.:|.:|
  Fly   139 -----------PQQQQQQLVSS-----------------NNSSSSSNNSFTKASSPNNNGARSVG 175

Human   187 --------GAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHQIHHGHH--------LQHG 235
                    |..:....|..|||               |.||.||||..||.|.        |..|
  Fly   176 GAATSAATGTTAAAGSHHHQPH---------------HHHHHHHHHHQHHNHQQQQQQQTSLSQG 225

Human   236 HHHPSHVAVASASITG----------GPPSSPVSRKLSTTGSSDSITPVAPTSAVSSSGSPASVM 290
            |...: ||..|||..|          |..:...:||..|| ||..||.|       :.|.|
  Fly   226 HASLT-VAGGSASAGGGGGGGSGSSSGTAAGGTNRKPKTT-SSFEITSV-------TVGHP---- 277

Human   291 TNMRAPSTTGGIGINSVTGTSTVNNVNITAVGSFNPNVTSSMLGNVNISTSN---------IPSA 346
             .:.|...||....:.:..:.|.:|..||.:.:..|:::........:..:|         ||::
  Fly   278 -KLNAAGDTGDESADDLDESHTDDNSRITDLENETPSMSEDTFSKEEVYYANNALSTNAPVIPTS 341

Human   347 AG---VSVGP-----GVT-SGVNVNILSGMGNGTISSSAAVSSVPNAAAGMTGGSVSSQQQQPTV 402
            :.   |.|.|     |.| ..|.||:...:.|..   |.||:         .||:......:.|.
  Fly   342 SQYGLVVVDPIAPSLGQTIQNVQVNVSDNIINVV---SGAVT---------PGGTKKKDDIKETQ 394

Human   403 NTS-RFRVVKLDSSSEPFKKGRWTCTEFYEKENAVPATEGVLINKVVETVKQNPIEVTSERESTS 466
            :.| ||:|||:: |:||||:|||.|.::.:..:.  ...|                  :..|.|.
  Fly   395 HRSERFKVVKIE-STEPFKRGRWMCMDYLDHSSV--GNGG------------------NNNEKTG 438

Human   467 GSSVSSSVSTLSHYTESVGSGEMG-----------APTV-----------------VVQQQQQQQ 503
            .|:..:..:|.......||:|...           .||.                 ..:||||||
  Fly   439 SSTSEAHAATTDGGAAGVGAGSEAPAHKTTQSMILPPTQKLNENHLEANSTDANWNYAEQQQQQQ 503

Human   504 QQQQQQPALQGVTLQQMDFGSTGPQSIPAVSIPQSISQSQISQVQLQSQELSYQQKQGLQPVPLQ 568
            ||||||..:.|..|.:     |.|.::..||...|:::|..:.|:..|..|..||:|..|.:...
  Fly   504 QQQQQQQTIVGNALTK-----TLPVALRNVSRSSSVTRSPNATVEFLSPNLLAQQQQQQQQLFDS 563

Human   569 ATMSAATGIQPS--PVNV-------------------------------------VGVTSALGQQ 594
            ...:||:...|:  |.|:                                     .|..||:|..
  Fly   564 VNANAASSPNPAGDPNNMDYARTAAMQLHQTLQQLKQREDAMDVPPGAGGYANYQNGGDSAVGAA 628

Human   595 PSISSLA-----------------QPQLPYS------QAAPPVQTPLPGAPPPQQLQYGQQQPMV 636
            .:.:|.|                 |.|.|.|      ||||.......|..|..||:..|||
  Fly   629 SNNNSAAAATGESQLSTSYVEQQQQQQQPLSPAPLTPQAAPTFAAVAAGQSPNFQLEQQQQQ--- 690

Human   637 STQMAPGHVKSVTQNPASEYVQQQPILQTAMSSGQPSSAGVGAGTTVIPVAQP------------ 689
              |.|...:..:...|.:...|||   ||...|....:|.....|:.:....|
  Fly   691 --QQATSQIDGIVPQPFNPQQQQQ---QTPQQSTAQQAAAAANATSAVTAPPPQQTSNTSNAAVT 750

Human   690 --QGIQLPV----------QPTAVPAQPAGASVQPVGQAPAAVSAVPT------GSQIANIGQQA 736
              ||..:|:          ||....|..|.|:......:.||..|:||      .|.||: .||.
  Fly   751 TGQGQTMPLLSHMTSYEQQQPNLGAAAAAAAAGGTAATSVAAPQAIPTLQLQSAPSTIAD-PQQL 814

Human   737 NIPTAVQ----QPSTQVPPSVIQQGAPPSSQVVPPA--------QTGIIHQG-VQTSAPSLPQQL 788
            .:|...|    |...|..|...||..||::.....|        .|.::..| ..|:|.:|..:.
  Fly   815 MVPQQQQQQQHQEEQQQQPQQQQQPLPPANIASASANNSNLNLTNTNVVATGEATTNALTLTDEQ 879

Human   789 VIASQSSLLTVPPQPQGVEPVAQGIVS------QQLPAVSSLPSASSISVTSQVSSTGPSGM--- 844
            ..|:.::....     |....|.|..|      ||:..:...|:|.| ...|.::::.|.|.
  Fly   880 ATAALAAAFAT-----GAAAAATGATSAAAATQQQIQQLQQQPNAES-ETESFITASNPGGNRKR 938

Human   845 ---------PSAPT--NLVPPQNIAQTPATQNGNLVQSVSQ-------PPLIATNTNLPLAQQI- 890
                     |:.|:  :.:.|| :.....:|:|.....|.:       |....::|||.:....
  Fly   939 AFSNPHIGGPNDPSFMHRLNPQ-LYYYNKSQSGRSSFCVDESLWPTNNPNGAVSDTNLYMGSSTD 1002

Human   891 --------PLSSTQFSAQSLAQAI------GSQIEDARRAAEPSL-VGLPQTISGDSGGMSAVSD 940
                    ..|.|.::.:|.::||      ||..:.....::|.: :|:.|.   :.||.:.
  Fly  1003 EDYEEAIDQFSPTIYTTRSASRAIPIPNSAGSSPQHQMHHSQPRIAIGINQM---EGGGPTR--- 1061

Human   941 GSSSSLAASASLFPLKVLP-----------------------------------LTTPLVDGED- 969
             |:.:.:||.|::.....|                                   |..|...|:.
  Fly  1062 -STGAFSASPSIYAYPHSPFYASSPETSFGSAAMPGHPAASSRISFSYDPAFQRLQVPNASGDRR 1125

Human   970 --------------------------------ESSSGASVVAIDNKIEQAMDLVKSHLMYAVREE 1002
                                            .|:||.|.|||||||||||||||||||.|||||
  Fly  1126 PRSPLECASVFAAVAAAATCGDAAGGAADTVISSASGTSAVAIDNKIEQAMDLVKSHLMIAVREE 1190

Human  1003 VEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPAT--TQPQGTTQPPAQPA 1065
            ||||||:|.||::|.::||.||::||:....|.|.|.|.|||..:||||  .|.....|....||
  Fly  1191 VEVLKERISELMDKINKLELENSILKSNIPQETLQQLQLQLQLAAPPATPAIQAAPAVQSVVAPA 1255

Human  1066 SQG 1068
            :.|
  Fly  1256 AAG 1258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TSC22D1	NP_904358.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..110		27/100 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	125..205		16/96 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..288		28/85 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..486		5/27 (19%)
		PAT1	555..>788	CDD:330585	75/337 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..628		8/26 (31%)
		RNase_E_G	<685..899	CDD:331378	60/292 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..766		8/27 (30%)
		TSC22	988..1034	CDD:307358	30/45 (67%)
		Leucine-zipper	1006..1027		11/20 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1037..1073		14/34 (41%)
bun	NP_001036357.2	TSC22	1176..1223	CDD:279505	30/46 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154584
Domainoid	1	1.000	124	1.000	Domainoid score	I5566
eggNOG	1	0.900	-	-		E1_KOG4797
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	180	1.000	Inparanoid score	I4008
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001302
OrthoInspector	1	1.000	-	-		otm42281
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46745
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2903
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.880