Protein Alignment ALKBH1 and AlkB

DIOPT Version :10

• Sequence 1: NP_006011.2
• Gene: ALKBH1 / 8846
• HGNCID: 17911
• Length: 389
• Species: Homo sapiens
• Sequence 2: NP_996458.1
• Gene: AlkB / 2768870
• FlyBaseID: FBgn0065035
• Length: 332
• Species: Drosophila melanogaster
• Alignment Length: 340
• Identity: 123/340 - (36%)
• Similarity: 184/340 - (54%)
• Gaps: 31/340 - (9%)

Human    23 FRKLFRFYRQSRPGTADLEGVIDFSAAHAARGKGPGAQKV---IKSQLNVSSVSEQNAYRAGLQP 84
            |:.:|:.|: .:..:.||..|:.......   ||...:|.   |..:|::|:| |......|::.
  Fly     2 FKLVFKQYK-CKSTSPDLTEVVKIDDCVV---KGNDQEKSDNNIVQRLSISNV-ESLQTMPGVKS 61

Human    85 VSKWQAYGLKGYPGFIFIPNPFLPGYQWHWVKQCLKLYSQKPNVCNLDKHMSKEETQ-DLWEQ-- 146
            ...|:.|.|..:||.|.|.|||....:.:|..:||:.:.:.||:.||::.:..|..: |.|:|
  Fly    62 PKDWRTYTLTNHPGIIVIRNPFSERGRRYWSARCLRDFPRTPNIVNLNERLFDESVRSDWWKQLN 126

Human   147 ----SKEFLRYKEATKRRPRSLLEKLRWVTVGYHYNWDSKKYSADHYTPFPSDLGFLSEQVAAAC 207
                ..||.|.|.|           :||.|.|||:|||:|.|..:..:|||.||..|....|.|.
  Fly   127 LCSDGVEFQRIKSA-----------MRWTTFGYHHNWDTKIYDEEMQSPFPEDLSSLCGLFAQAL 180

Human   208 GFEDFRAEAGILNYYRLDSTLGIHVDRSELDHSKPLLSFSFGQSAIFLLGGLQRDEAPTAMFMHS 272
            |:.||:.||.|:|||.:.|||..|.|.||.:.|.||.||||||:||||:||...:|.|||:::.|
  Fly   181 GYADFKPEAAIVNYYPVGSTLSGHTDHSEPNKSAPLFSFSFGQTAIFLIGGRSLEEKPTAIYLQS 245

Human   273 GDIMIMSGFSRLLNHAVPRVLPNPEGEGLPHCLE----APLPA-VLPRDSMVEPCSMEDWQVCAS 332
            ||:|||||.|||..|||||::.......|...:|    |.:.. .:.:|...:..:.:.|:..:.
  Fly   246 GDVMIMSGESRLCYHAVPRIIKTQASATLSLIIEDVDNADIKTRTIDKDLFHDVGNPQFWEPFSR 310

Human   333 YLKTARVNMTVRQVL 347
            |:..:|:|:.:||||
  Fly   311 YMDDSRININIRQVL 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALKBH1	NP_006011.2	tRNA-binding. /evidence=ECO:0000305|PubMed:27745969	86..389		108/274 (39%)
		alkb	119..289	CDD:129659	80/176 (45%)
AlkB	NP_996458.1	2OG-FeII_Oxy_2	75..267	CDD:433285	92/202 (46%)