DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CFLAR and Decay

DIOPT Version :9

Sequence 1:NP_001120655.1 Gene:CFLAR / 8837 HGNCID:1876 Length:480 Species:Homo sapiens
Sequence 2:NP_477462.1 Gene:Decay / 42008 FlyBaseID:FBgn0028381 Length:308 Species:Drosophila melanogaster


Alignment Length:294 Identity:72/294 - (24%)
Similarity:117/294 - (39%) Gaps:50/294 - (17%)


- Green bases have known domain annotations that are detailed below.


Human   200 NFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLII---DCIG 261
            :|.|...::|.::.|.............:......:.:...|:.|:..:: .||.||:   |..|
  Fly     5 DFSLFGQKNKHKKDKADATKIAHTPTSELDLKRIIISRPTNEDTYENCAR-AGIALILNHKDVKG 68

Human   262 NE----TELLRD----TFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGS 318
            .:    ||..||    |....|::|:.|..|:...|:..|.:.| ..:|...|.||..::|.|..
  Fly    69 QKQRVGTERDRDDMEATLQGFGFDVRTFDDLTFSEINDTLKEVA-REDHSQNDCFVLAVMSHGTE 132

Human   319 QSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQ-----NYVVSEGQLEDSS------- 371
            ..||..|.::   |:..:...|:||:|..|..|||:||||     |.   |..:|.||       
  Fly   133 GKVYAKDMSY---PVERLWNPFLGDNCKTLKNKPKLFFIQACRGANL---EKAVEFSSFAVMTRE 191

Human   372 LLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQ--- 433
            |:.....|::.:.:        .:...||......|.|.....::....|.::|.|.:.|.|   
  Fly   192 LVPEPAAAVQPITY--------AIPSTADILVFYSTFDKFFSFRNVDDGSWFIQSLCRVLDQAAA 248

Human   434 -ERKRP----LLDLHIELN---GYMYDWNSRVSA 459
             |...|    ||.|...:|   .|.|..|::..|
  Fly   249 NEAATPEGVELLRLLTAVNRKVAYEYQSNTKNEA 282

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CFLARNP_001120655.1 Not proteolytically processed and involved in apoptosis inhibition 1..435 62/261 (24%)
Interaction with CASP8 propeptide. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610 1..305 25/115 (22%)
Interaction with FADD. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610 1..227 4/26 (15%)
Interaction with CASP8. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610 1..195
DED_c-FLIP_r1 1..80 CDD:260044
DED_c-FLIP_r2 91..171 CDD:260046
Interaction with TRAF1 and TRAF2. /evidence=ECO:0000269|PubMed:9208847 192..480 72/294 (24%)
Interaction with CASP3. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610 192..435 62/261 (24%)
Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610 217..480 68/277 (25%)
CASc 244..479 CDD:214521 67/250 (27%)
Caspase 263..358 32/102 (31%)
Interaction with CASP8. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610 370..480 23/108 (21%)
DecayNP_477462.1 CASc 54..302 CDD:237997 66/245 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152737
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3573
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.740

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