Protein Alignment CFLAR and Strica

DIOPT Version :9

• Sequence 1: NP_001120655.1
• Gene: CFLAR / 8837
• HGNCID: 1876
• Length: 480
• Species: Homo sapiens
• Sequence 2: NP_001260718.1
• Gene: Strica / 35528
• FlyBaseID: FBgn0033051
• Length: 527
• Species: Drosophila melanogaster
• Alignment Length: 346
• Identity: 61/346 - (17%)
• Similarity: 104/346 - (30%)
• Gaps: 135/346 - (39%)

Human   165 KTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQ 229
            |.|:....||....||         |..||           |.||....|.:|    :|.:..|.
  Fly   278 KPKVTAVAQSQDAQGT---------ISTSL-----------GISKSSLTKNKL----KPARVYIF 318

Human   230 ESEAFLPQSIPEERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILG 294
            ..|.|      :.:.:.:...          ..:.::||.||..|..:|:.....::..|.:.:.
  Fly   319 NHERF------DNKNEFRKGS----------AQDVKVLRATFEQLKCKVEVITDATLVTIKKTVR 367

Human   295 QFACMPEHRDYD---SFVCVLVSRG-GSQSVYGVDQTHSGLPLHHIRRMFMGDSCPY-------L 348
                |.:.:|::   :.|.|::|.| ....:...|..:|           :.|...:       |
  Fly   368 ----MLQTKDFEDKSALVLVILSHGTRHDQIAAKDDDYS-----------LDDDVVFPILRNRTL 417

Human   349 AGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSL- 412
            ..|||:.|:|                                              .|..|..|
  Fly   418 KDKPKLIFVQ----------------------------------------------ACKGDCQLG 436

Human   413 -----LEQSHSSPSLYLQCLSQ-----KLRQERKRPLLDLHIE-LN--GYMYDWNS--------- 455
                 ..|.:.||:..|:|.|.     ..|.|...|.:....| ||  |...|.::
  Fly   437 GFMTDAAQPNGSPNEILKCYSTYEGFVSFRTEDGTPFIQTLCEALNRSGKTSDIDTIMMNVRQVV 501

Human   456 RVSAKEKYYVWLQHTLRKKLI 476
            ::.:|::....:..||..|.:
  Fly   502 KMQSKDRQIPSVTSTLTSKYV 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CFLAR	NP_001120655.1	Not proteolytically processed and involved in apoptosis inhibition	1..435		50/291 (17%)
		Interaction with CASP8 propeptide. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	1..305		26/139 (19%)
		Interaction with FADD. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	1..227		15/61 (25%)
		Interaction with CASP8. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	1..195		8/29 (28%)
		DED_c-FLIP_r1	1..80	CDD:260044
		DED_c-FLIP_r2	91..171	CDD:260046	2/5 (40%)
		Interaction with TRAF1 and TRAF2. /evidence=ECO:0000269|PubMed:9208847	192..480		54/319 (17%)
		Interaction with CASP3. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	192..435		43/264 (16%)
		Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	217..480		48/294 (16%)
		CASc	244..479	CDD:214521	43/267 (16%)
		Caspase	263..358		21/105 (20%)
		Interaction with CASP8. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	370..480		21/130 (16%)
Strica	NP_001260718.1	CASc	311..523	CDD:294037	47/289 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810