Protein Alignment CFLAR and ced-3

DIOPT Version :10

• Sequence 1: NP_003870.4
• Gene: CFLAR / 8837
• HGNCID: 1876
• Length: 480
• Species: Homo sapiens
• Sequence 2: NP_001255708.1
• Gene: ced-3 / 178272
• WormBaseID: WBGene00000417
• Length: 503
• Species: Caenorhabditis elegans
• Alignment Length: 536
• Identity: 100/536 - (18%)
• Similarity: 185/536 - (34%)
• Gaps: 181/536 - (33%)

Human    71 ILKMDRKA-VETHLLR-NPHLVSDYRVLMAEIGEDLDKSDVSSLI-----------FLMKDYMGR 122
            :::.||:: :|.:::. :.||..| .:|...|.:.:..||...:|           .::|....|
 Worm     1 MMRQDRRSLLERNIMMFSSHLKVD-EILEVLIAKQVLNSDNGDMINSCGTVREKRREIVKAVQRR 64

Human   123 GKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNI---------------HR---------ID 163
            |.::.: :|.|.:.......|.     ::||...:::               ||         ..
 Worm    65 GDVAFD-AFYDALRSTGHEGLA-----EVLEPLARSVDSNAVEFECPMSPASHRRSRALSPAGYT 123

Human   164 LKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKK-- 226
            ..|::.:...|...:.|||:::...|..:|             ||:.....::......||..
 Worm   124 SPTRVHRDSVSSVSSFTSYQDIYSRARSRS-------------RSRALHSSDRHNYSSPPVNAFP 175

Human   227 ------------------SIQESEAFLPQSIPEE------------------------RYKMKSK 249
                              |...:.:|...|.|.:                        .|:..|.
 Worm   176 SQPSSANSSFTGCSSLGYSSSRNRSFSKASGPTQYIFHEEDMNFVDAPTISRVFDEKTMYRNFSS 240

Human   250 PLGICLIIDCIGNE----------TELLRDTFTSL----GYEVQKFLHLSMHGISQILGQFACMP 300
            |.|:||||:   ||          |:..:|..|:|    ||.|....:|:..|:...:..||
 Worm   241 PRGMCLIIN---NEHFEQMPTRNGTKADKDNLTNLFRCMGYTVICKDNLTGRGMLLTIRDFA--- 299

Human   301 EHRDY-DSFVCVLVSRGGSQSVYGVDQTHSGLPL--HHIRRMFMGDSCPYLAGKPKMFFIQNYVV 362
            :|..: ||.:.|::|.|....:.|||.    :|:  |.|..:....:.|.||.|||:.|:|   .
 Worm   300 KHESHGDSAILVILSHGEENVIIGVDD----IPISTHEIYDLLNAANAPRLANKPKIVFVQ---A 357

Human   363 SEGQLEDSS---LLEVDG------------------------PAMKNVEFKAQKRGLCTVHREAD 400
            ..|:..|:.   |..|||                        |.::.|..|...        :||
 Worm   358 CRGERRDNGFPVLDSVDGVPAFLRRGWDNRDGPLFNFLGCVRPQVQQVWRKKPS--------QAD 414

Human   401 FFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQERK-RPLLDLHIELN-----GYMYDWNSRVSA 459
            ...:..|....:..::.:..|.::|.:.:......| ..:::|..|:|     |:.....|.:..
 Worm   415 ILIAYATTAQYVSWRNSARGSWFIQAVCEVFSTHAKDMDVVELLTEVNKKVACGFQTSQGSNILK 479

Human   460 K---------EKYYVW 466
            :         :|:|.|
 Worm   480 QMPEMTSRLLKKFYFW 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CFLAR	NP_003870.4	Not proteolytically processed and involved in apoptosis inhibition	1..435		91/488 (19%)
		Interaction with CASP8 propeptide. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	1..305		58/328 (18%)
		Interaction with FADD. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	1..227		32/212 (15%)
		Interaction with CASP8. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	1..195		28/160 (18%)
		DED_c-FLIP_r1	1..80	CDD:260044	2/9 (22%)
		DED_c-FLIP_r2	91..171	CDD:260046	17/114 (15%)
		Interaction with TRAF1 and TRAF2. /evidence=ECO:0000269|PubMed:9208847	192..480		73/378 (19%)
		Interaction with CASP3. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	192..435		64/330 (19%)
		Interaction with CASP8 subunits p18 and p10. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	217..480		70/353 (20%)
		CASc	244..479	CDD:214521	64/282 (23%)
		Caspase	263..358		31/111 (28%)
		Interaction with CASP8. /evidence=ECO:0000269|PubMed:9208847, ECO:0000269|PubMed:9326610	370..480		21/139 (15%)
ced-3	NP_001255708.1	CARD	2..90	CDD:128424	18/94 (19%)
		CASc	235..496	CDD:214521	64/282 (23%)