Protein Alignment GGH and l(3)72Dr

DIOPT Version :10

• Sequence 1: NP_003869.1
• Gene: GGH / 8836
• HGNCID: 4248
• Length: 318
• Species: Homo sapiens
• Sequence 2: NP_730120.1
• Gene: l(3)72Dr / 39778
• FlyBaseID: FBgn0263608
• Length: 345
• Species: Drosophila melanogaster
• Alignment Length: 314
• Identity: 96/314 - (30%)
• Similarity: 172/314 - (54%)
• Gaps: 31/314 - (9%)

Human    34 PIIGILMQKCRNKVMKNY-GRY--YIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILF 95
            |.:|::......::.:|: |.|  |:||||||:||::||.|||:.:......|.::...:||||.
  Fly    16 PTVGVMCIDIATQLQQNFSGAYHSYLAASYVKFLEASGAHVVPIWIGRERAYYALMMSQLNGILL 80

Human    96 PGGSVDLRR----------SDYAKVAKIFYNLSIQ------SFDD-GDYFPVWGTCLGFEELSLL 143
            |||:|.:..          ||..:.|::.|.|:::      ..|| |.||||||||||| :|.|:
  Fly    81 PGGAVFIDEADRQANPDVTSDCVRSAELIYQLAMERNMRAKKLDDRGAYFPVWGTCLGF-QLILI 144

Human   144 ISGEC--LLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTM 206
            .:.|.  :..|...:..|||:..|.....|::..:.|..:...:...|...:.|::.:: |....
  Fly   145 HAAEAPNVRIACQPMREAMPVTLTDDYQQSQLLGSLPKSVADEMEKHPFACHQHRYCIT-KESLE 208

Human   207 NEKLKKFFNVLTTNTD-GKIEFISTMEGYKYPVYGVQWHPEKAPYE--WKNLDG--ISHAPNAVK 266
            :..|.|.::.|.|..| ..:|||:.:|..::|::|.|:|||:|.:|  :.:.|.  ::|:...:.
  Fly   209 SYGLAKDWHPLATQKDTSGLEFITIVEHRRFPIFGCQFHPERAAFEQLFNSPDKCYMAHSRMGID 273

Human   267 TAFYLAEFFVNEARKNNHHFKSESEEEKALIYQFSPIYTGNI--SSFQQCYIFD 318
            .:......||:..|:||:.|:|:..:.:.||:.:.|:::|..  |::||||:|:
  Fly   274 LSQIFGSRFVDFCRRNNNQFESDKLKTRHLIWNWQPVFSGKFKGSNWQQCYLFE 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GGH	NP_003869.1	GATase1_Glutamyl_Hydrolase	36..306	CDD:153218	88/296 (30%)
l(3)72Dr	NP_730120.1	GATase1_Glutamyl_Hydrolase	23..313	CDD:153218	87/291 (30%)