Protein Alignment GGH and l(3)72Dp

DIOPT Version :10

• Sequence 1: NP_003869.1
• Gene: GGH / 8836
• HGNCID: 4248
• Length: 318
• Species: Homo sapiens
• Sequence 2: NP_730119.1
• Gene: l(3)72Dp / 317887
• FlyBaseID: FBgn0263607
• Length: 373
• Species: Drosophila melanogaster
• Alignment Length: 330
• Identity: 120/330 - (36%)
• Similarity: 181/330 - (54%)
• Gaps: 41/330 - (12%)

Human     7 LLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKC----------RNKVMKNYGRYYIAASYV 61
            ||..:|.|| .|:...:|        .||||:|.|:.          .||..      |||||||
  Fly     8 LLIFIGALL-AASEAGIS--------SPIIGVLTQEVYVDGLISRHFDNKTS------YIAASYV 57

Human    62 KYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSD-YAKVAKIFYNLSIQSFDDG 125
            ||||.|||||||:.:......|:.|.:.|||:|.|||:....:|: ||...:...:|:|:..|.|
  Fly    58 KYLEGAGARVVPIWIGRNRSYYDDLMRKINGVLLPGGATWFNQSNGYADAGEHLIHLAIELNDQG 122

Human   126 DYFPVWGTCLGFEELSLLISGE------CLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLS 184
            .:.||||||||.|.|...::.|      |     :...:|:|:.|......||:|.:...:::.:
  Fly   123 VFMPVWGTCLGMELLVYKLANETEHRINC-----EATGMAVPMEFKEDYKKSRLFASITDDVVDT 182

Human   185 LAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTD-GKIEFISTMEGYKYPVYGVQWHPEKA 248
            :..|.:|.::|::..:.|:|. .:.|.:.:.|::.|.| ..:|||||:|..|||.||||:||||.
  Fly   183 MVKENVTYHWHQFCYTEKDFE-RDLLNETWRVMSLNHDWNGVEFISTVEHIKYPFYGVQFHPEKP 246

Human   249 PYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQFSPIYTGNI-SSFQ 312
            .||:.. ..|.|...||.:..:.|:|||:|||::|..|.:.:|:.:.|||.:.|.||..: ||:.
  Fly   247 LYEFTK-TSIPHTAAAVLSGQFFADFFVSEARESNQSFSNATEQARTLIYNYKPEYTSILGSSYI 310

Human   313 QCYIF 317
            |.|:|
  Fly   311 QQYLF 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GGH	NP_003869.1	GATase1_Glutamyl_Hydrolase	36..306	CDD:153218	105/287 (37%)
l(3)72Dp	NP_730119.1	GATase1_Glutamyl_Hydrolase	28..303	CDD:153218	105/287 (37%)