DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KYAT1 and Kyat

DIOPT Version :9

Sequence 1:	NP_001274319.1	Gene:	KYAT1 / 883	HGNCID:	1564	Length:	516	Species:	Homo sapiens
Sequence 2:	NP_650121.1	Gene:	Kyat / 41433	FlyBaseID:	FBgn0037955	Length:	450	Species:	Drosophila melanogaster

Alignment Length:	453	Identity:	203/453 - (44%)
Similarity:	289/453 - (63%)	Gaps:	14/453 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    68 CE--VPAAEGILRTGGAKLPIQGHPAKLAMAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQG 130
            |:  :.||:..||.......::.....:.|.|....:||.|...:.|.|::.||.::..:|||||
  Fly     5 CQLTLSAAKRSLREQFQLQALRHQQTAIKMEKFDLPKRLQGSTPSVWNEYIALAMQYKPLNLGQG 69

Human   131 FPDFPPPDFAVEAFQH-AVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGG 194
            |||...|::...:... |...:.:|:|||:.:|:..|...|:..:..|:|:|::||.::|:|.|.
  Fly    70 FPDDAAPEYVTHSLADIAKEQNPLLHQYTRGYGHVRLVNALSKLYSGLVGKELNPLSDILITSGA 134

Human   195 YGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLK----PGPIQNGELGSSSNWQ 255
            |.||::.....||.|||||||||||||||||..||||.|.||.||    .|||      ||::|.
  Fly   135 YEALYSTIMGHVDVGDEVIIIEPFFDCYEPMVKMAGGVPRFVPLKLRKTEGPI------SSADWV 193

Human   256 LDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQH 320
            ||..|....|.|:||.::||||:||:||||:|:|||.:|.||::.:|:|::||||:|:|:||.:|
  Fly   194 LDDAEFESLFNSKTKMIILNTPHNPIGKVFNRKELERIAELCRKWNVLCVSDEVYEWLVFDGAEH 258

Human   321 ISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAES 385
            |.|.:|||||:||:|:||||||||.||||:||..||..::::|:.||||||:.|||..|..||.|
  Fly   259 IRICTLPGMWDRTITLGSAGKTFSVTGWKIGWAYGPAELIRNLQMVHQNSVYTCPTPLQEGVARS 323

Human   386 FEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPG 450
            ||.|.....||.|||:..|:.:::.||.|.:.|...|::|.||:|.||::.|.|....|: ||..
  Fly   324 FEVELARLGQPESYFLSLPRELKQKRDFMAKFLSESGMRPTIPEGGYFMLADWSPLAGKI-DLSS 387

Human   451 AVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWK 513
            ..|:..|.:|.|||.||.||..||.|.|||.|::...:.::|:||:|.:..|....|.|.|||
  Fly   388 EPDKHRDYKFTKWMTKNMGLQGIPPSAFYSEPNKHLGEDFVRYCFIKKQENLDKAAELLSKWK 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KYAT1	NP_001274319.1	Aminotran_1_2	118..512	CDD:332562	188/398 (47%)
Kyat	NP_650121.1	PRK08912	56..449	CDD:181580	188/399 (47%)
Kyat	NP_650121.1	AAT_like	64..448	CDD:99734	186/390 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0436
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53781
OrthoDB	1	1.010	-	-		D396367at33208
OrthoFinder	1	1.000	-	-		FOG0001158
OrthoInspector	1	1.000	-	-		otm41641
orthoMCL	1	0.900	-	-		OOG6_100255
Panther	1	1.100	-	-	LDO	PTHR43807
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1782
SonicParanoid	1	1.000	-	-		X786
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.820