DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CES2 and Nlg3

DIOPT Version :9

Sequence 1:	NP_001352334.1	Gene:	CES2 / 8824	HGNCID:	1864	Length:	559	Species:	Homo sapiens
Sequence 2:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster

Alignment Length:	658	Identity:	178/658 - (27%)
Similarity:	281/658 - (42%)	Gaps:	145/658 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    30 ASPIRTTHTGQVLGSLVHVKGANAG-VQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPA 93
            :|.|..|..|.:.|.:|.:.|.:.. |:.:.|||:|.||:|.|||.||.....||||:.......
  Fly   154 SSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSP 218

Human    94 MCLQDLTAVESEF----------LSQFNMTFP-SDSMSEDCLYLSIYTP------------AHSH 135
            :|.|.|..:.:|.          |.......| ..:.|||||||:||.|            :.|.
  Fly   219 VCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSS 283

Human   136 EGSN----------------------------LPVMVWIHGGALVFGMASLYDGSMLAALENVVV 172
            .||:                            .||:|::||.:..:...:.||||:||:...::|
  Fly   284 AGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQILV 348

Human   173 VIIQYRLGVLGFFSTG-DKHA--TGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSV 234
            |.|.||||||||.:.. |:::  ..|:|.:|.:|||.|:::|||.|||:|:.:|:.|...|...|
  Fly   349 VTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACV 413

Human   235 SSLVVS-PISQG-LFHGAIMESGVALLP-GLIASSADVISTVVANLSACDQVDSEALVGCLRGKS 296
            ..|:.| .:.:| ||:.||:.||..|.| .|:::.|...:.|..:::....:....|:.|||.|:
  Fly   414 HFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREKT 478

Human   297 KEEILAINKPFK----------MIPGVV--DGVFLPRHPQELLASADFQPVPSIVGVNNNEF--- 346
            .:::|::  |.:          .|.|||  .|.::|..|....|.|..|...:.......|.
  Fly   479 LDQLLSV--PIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIA 541

Human   347 ---GWLIP---------------KVMRIYDTQK--------------------EMDREAS--QAA 371
               ||..|               |:.| ||...                    |.||.:.  :|.
  Fly   542 AAGGWGTPGQLENIVLMRKTAINKLSR-YDLMAGVTRAEAFFSFNSGDVQYGIEADRRSRILKAY 605

Human   372 LQKMLTLLMLPPTFGDLLRE--EYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHF-QCSRAPV 433
            ::...| ..|...|..::.|  ::......|..::.:..|.::|:..|.||.|.... .......
  Fly   606 VRNTYT-FHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDAQVVAPAAQTVDLHSADHRNS 669

Human   434 YFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKF----TEEEEQLSRKMMKYWANF 494
            |.|.|.:|..:  ...|......||::||::|.:...|.:..|    |:.|..||..:|.||:||
  Fly   670 YLYVFDYQTRF--GDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMFYWSNF 732

Human   495 ARNGNPNGE-GLPH-------------WPLFDQ-EEQYLQLNLQPAVGRALKAHRLQFWKKALPQ 544
            .|.||||.: ...|             |..::. .::||..:.:|.:....:||||.||...:|
  Fly   733 VRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRLSFWLNLIP- 796

Human   545 KIQELEEP 552
               :|.:|
  Fly   797 ---DLHKP 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CES2	NP_001352334.1	COesterase	30..538	CDD:306613	173/642 (27%)
CES2	NP_001352334.1	Prevents secretion from ER. /evidence=ECO:0000255	556..559
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	173/642 (27%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	39/96 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142568
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740