DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CES2 and alpha-Est2

DIOPT Version :9

Sequence 1:	NP_001352334.1	Gene:	CES2 / 8824	HGNCID:	1864	Length:	559	Species:	Homo sapiens
Sequence 2:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	165/553 - (29%)
Similarity:	234/553 - (42%)	Gaps:	112/553 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    33 IRTTHT-------GQVLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTT 90
            :.|.||       |||.|..............|.|||:||||:|.|||..|:|||.|.||.:.||
  Fly    27 LSTGHTVILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLNCTT 91

Human    91 HPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGM 155
            :.:..:|.            ||.......|||||:|::|..|...| ..|||:|||:||....|.
  Fly    92 NRSKPMQR------------NMLLGIVEGSEDCLHLNVYVKALKSE-KPLPVIVWIYGGGFQKGE 143

Human   156 AS--LYDGSMLAALENVVVVIIQYRLGVLGFFSTGDK--HATGNWGYLDQVAALRWVQQNIAHFG 216
            ||  :|....... :.||.|.|.|||..|||.|..|.  ...||.|..|||.||||:.||||||.
  Fly   144 ASRDIYSPDYFMK-KPVVFVAINYRLAALGFLSLKDPKLDVPGNAGLKDQVMALRWISQNIAHFN 207

Human   217 GNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLS-AC 280
            |:|:.:|:.|||||..||..::.:..::||||.|||:||.||...:.:...:....:..||. ..
  Fly   208 GDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVESPDNNWAFRLAQNLGYKG 272

Human   281 DQVDSEALVGCLRGKSKEEILAIN---------KPFKMI-------PGVVDGVFLPRHPQELLAS 329
            |:.|::.| ..|......:|.||:         :.|.:.       |...|...:|:..::||:.
  Fly   273 DEKDADVL-SFLSKVCARQIAAIDQDVINLDEVRSFLLFAFGPVIEPYETDHCVVPKRHKDLLSE 336

Human   330 ADFQPVPSIVGVNNNE--FGW-LIPK----VMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGD 387
            |....:|.|||.|:.|  |.: |:.|    :...::......||.|....|.:|.
  Fly   337 AWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPREVRETSSLEGQDLLV---------- 391

Human   388 LLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQV-AHFQ---------------CSRAPVYFY 436
                        .:..|..|...|.:||.:..||.: :|.|               ..:.|.|.|
  Fly   392 ------------RRLKQLYFNNEMQESMEMFEALNIFSHRQIWHDTHRFILARQSYAPKTPTYLY 444

Human   437 EFQHQPSWLKNIRPPHMK-------------ADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMM 488
            .|        :...||..             ..|.|||.::|.:.......|.:.|.:.:.| |:
  Fly   445 RF--------DFDSPHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASKLDKSSMEYKTIER-MV 500

Human   489 KYWANFARNGNPNGE--GLPHWPLFDQEEQYLQ 519
            ..|.:||.:||||..  |...|.....:|..::
  Fly   501 GMWTSFASSGNPNCPELGSAKWEAVQLKENAVE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CES2	NP_001352334.1	COesterase	30..538	CDD:306613	165/553 (30%)
CES2	NP_001352334.1	Prevents secretion from ER. /evidence=ECO:0000255	556..559
alpha-Est2	NP_001262345.1	COesterase	32..523	CDD:278561	161/536 (30%)
alpha-Est2	NP_001262345.1	Aes	<117..>221	CDD:223730	49/105 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142688
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.690