Protein Alignment INPP4B and CG42271

DIOPT Version :10

• Sequence 1: XP_011530693.1
• Gene: INPP4B / 8821
• HGNCID: 6075
• Length: 947
• Species: Homo sapiens
• Sequence 2: NP_996434.2
• Gene: CG42271 / 2768892
• FlyBaseID: FBgn0259166
• Length: 1280
• Species: Drosophila melanogaster
• Alignment Length: 1098
• Identity: 271/1098 - (24%)
• Similarity: 433/1098 - (39%)
• Gaps: 299/1098 - (27%)

Human    39 PQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLT--RYSSTEIVEGTRDPLFLTGVTFPSE 101
            |..|..|:|..|......|..|..|..|::....:...  .::.||:.|.||.|.||..:.|...
  Fly   201 PICETALSCDTLPLDTLGRPPNPQVVCSLLPTAGEDCVWREHARTELQERTRTPQFLCTMRFQRS 265

Human   102 YPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLVLS 166
            ..:...|:::.:|:||:::    :..:.:|             ||:|...:|.:..:....|.|
  Fly   266 AGLSASTRLRFSVFDVRER----MTLTAVP-------------LGHAEVALGVIQDTSRLRLPL- 312

Human   167 LRTSDGGKVVGTIEV------SVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLP 225
              ||..|: .|.|.:      :.|:.|:..:|.....|....|...|.....::..:.....:||
  Fly   313 --TSPRGE-CGFITLASWSPDAAVEPGQSGNGPPRSSTQLFDGSAGAGGATTSSRRAHRRTQSLP 374

Human   226 -------------FLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDL 277
                         .|..|..||..:.||..:|....:.::|.:.||.|...:|::|:|:.|:.:.
  Fly   375 PKLGVRLFVPQQCGLQRVCSNPRLRTYRLHSSLGADISVQETLLESRLCCQLPQQLLSIWIQREK 439

Human   278 CRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDI---LTELSKETGSSFKSSSSKGEKTLEF 339
            ...|||..:||||..|...:.|:|....:::..|...   :.:|::: |.|||.||:|.:::|||
  Fly   440 ELLQEISGMGELSGEWRWRQMNLLEEHLRLLKDYSQAKQNIQQLARD-GVSFKRSSAKADESLEF 503

Human   340 VPINLHLQRMQVHSPHLKDISSGIPQIDALYDVITVGAPAAHF-QGFKNGGLRKLLHRFETERRN 403
            :|:|||:|||...:..|        |...|.||:||||...|. :|.|.|||.|||...::.:
  Fly   504 LPVNLHVQRMWAQNDTL--------QRRGLLDVVTVGAFTRHDPKGRKCGGLIKLLQESKSWK-- 558

Human   404 TGYQFIYYSPENTAK---AKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTEL 465
                   ....|..|   |.:.:....||:..|......||..||:.|...:......:..:|..
  Fly   559 -------LEQSNACKVQAANDAVQATKQLRKEIVELMSQLLQLASRRSSMDMMPLCNQMVARTRT 616

Human   466 FVHAFKDQLVRSALLALYTAR----PGGILKKPPSP-KSSTEESS-------------------- 505
            .::.::..:|..|:..:...|    |..:|.:|.|| :..|::.:
  Fly   617 LLNLWEPSIVEEAVAFIERHRIIEEPENVLMEPMSPFRKITQQLTALELKSPELEDFATPVVAPP 681

Human   506 ---PQDQPPVMRGQ------------------DSIPH----HSDY---------------DEEE- 529
               |:.|||:||..                  ||:.|    ::|:               |||:
  Fly   682 DLWPRGQPPLMRSNSWHPSNSSPSSSLDIRAIDSLQHVVKCYNDHLRSLEQGRQPGRQADDEEQE 746

Human   530 ----------W------------------------------------------------------ 530
                      |
  Fly   747 EATYQSLPVAWQTQSEVSAGTQIPPSDNPADLSVLQLIDLDEIGRQAQRQRHHQPPAGFLDTKLM 811

Human   531 ------------------DRVWANVGKSLNCIIAMVDKL--------------------IERDG- 556
                              |....|:..|:.|   :|.||                    |:|:|
  Fly   812 SSSPSANYYRPTEEPEPLDLTQLNIEASVMC---LVSKLKFFCGRCDSPAIRLRHPKAPIKREGF 873

Human   557 ------------GSEGSGG--------------NNDG---------EKEPSLTDAIPSHPREDWY 586
                        .|..||.              ::||         :|....||.:......||.
  Fly   874 AVAPQQAPDVIAASAASGKQAPNLALDLKPQSVDSDGITTTGSVAVKKGNKFTDGLDLSMTTDWA 938

Human   587 EQLYPLILTLKDCMGEVVNRAKQSLTFVLLQE--LAYSLPQCLMLTLRRDIVFSQALAGLVCGFI 649
            .:|.|.:..|:..|..::..|:...:...||:  ....|...:|  .|||:.|||||..||...:
  Fly   939 AELRPSMRKLRHAMDRLLKTARLMHSVQRLQQDMRCNRLQASIM--YRRDVCFSQALTALVSSLM 1001

Human   650 IKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAK---SN 711
            ::|..|..|.|:|..|..:|.:..:||||:.|.:|..|..||.:.|.||..|:|:::.|:   :.
  Fly  1002 LRLWGSELDMGYLVMLRDLGPLAYFEGLLTLYGNEADMWSDMCIAIEDLSAVSFQLVRAQGEVAQ 1066

Human   712 DVLPVITGRREHYVVEVKLPARMFESLP-----LQIKEGQLLHVYPVLFNVGINEQQTLAERFGD 771
            ...|.|||.|:  .:||:||... .|||     :..|      :.||.||:||||:.:.||..|.
  Fly  1067 TPTPRITGSRQ--ALEVQLPVPE-HSLPGNGNSISFK------ITPVFFNIGINEKASFAETLGQ 1122

Human   772 VSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLA 836
            ...|...|.:|:..|.:|:..: .|:.   :........|::||..:.|.:::...|||:|:.||
  Fly  1123 TKEQHRSNWDNYLRLSQYFGRY-RKLG---LGSVDTGESLQSLLGFMEQQLRANVSKNVKILHLA 1183

Human   837 ATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRSRQTQ 894
            ...||.::|:|||.||||||||.|:||||||.:|..|.||.......||..|||..|:
  Fly  1184 EDACRLMDGLRFTSCKSAKDRTGMAVTLEQCRVLVREFQLPAKHVPYALSTMRSEGTR 1241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP4B	XP_011530693.1	C2A_Copine	39..175	CDD:176013	32/137 (23%)
CG42271	NP_996434.2	PH_INPP4A_INPP4B	1..145	CDD:270091
		C2	201..318	CDD:472691	31/136 (23%)