Protein Alignment CDKL1 and CDC28

DIOPT Version :10

• Sequence 1: NP_004187.3
• Gene: CDKL1 / 8814
• HGNCID: 1781
• Length: 357
• Species: Homo sapiens
• Sequence 2: NP_009718.3
• Gene: CDC28 / 852457
• SGDID: S000000364
• Length: 298
• Species: Saccharomyces cerevisiae
• Alignment Length: 300
• Identity: 111/300 - (37%)
• Similarity: 171/300 - (56%)
• Gaps: 20/300 - (6%)

Human     1 MEKYEKIGKIGEGSYGVVFKCRNRDTGQ---IVAIKKF-LESEDDPVIKKIALREIRMLKQLKHP 61
            :..|:::.|:|||:||||:|..:...||   :||:||. |||||:.| ...|:|||.:||:||..
Yeast     5 LANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGV-PSTAIREISLLKELKDD 68

Human    62 NLVNLLEVFRR-KRRLHLVFEYCDHTVLHELDRYQRGVPE------HLVKSITWQTLQAVNFCHK 119
            |:|.|.::... ..:|:||||:.|    .:|.||..|:|:      .:||....|..:.:.:||.
Yeast    69 NIVRLYDIVHSDAHKLYLVFEFLD----LDLKRYMEGIPKDQPLGADIVKKFMMQLCKGIAYCHS 129

Human   120 HNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVD 184
            |..:|||:||:|:||.|...:||.|||.||....|...||..:.|.|||:||:|:|..||...||
Yeast   130 HRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVD 194

Human   185 VWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPE-DMEP 248
            .|:|||:|||:.:..|::.|.|::||::.|.:.||   ..::.::....|....|...|: ..:.
Yeast   195 TWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLG---TPNEAIWPDIVYLPDFKPSFPQWRRKD 256

Human   249 LELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFE 288
            |....|::....:.||...|..||..|::..:...||||:
Yeast   257 LSQVVPSLDPRGIDLLDKLLAYDPINRISARRAAIHPYFQ 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL1	NP_004187.3	STKc_CDKL1_4	2..287	CDD:270837	109/296 (37%)
		[NKR]KIAxRE	45..51		1/5 (20%)
CDC28	NP_009718.3	STKc_CDK1_CdkB_like	8..295	CDD:270829	109/294 (37%)