DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDKL1 and cdkl1

DIOPT Version :9

Sequence 1:	XP_005268214.1	Gene:	CDKL1 / 8814	HGNCID:	1781	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_001003773.1	Gene:	cdkl1 / 445316	ZFINID:	ZDB-GENE-040808-34	Length:	350	Species:	Danio rerio

Alignment Length:	358	Identity:	276/358 - (77%)
Similarity:	314/358 - (87%)	Gaps:	9/358 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVN 66
            |||||||.|||||||||||||||:|||||||||||:||||||:||||||||||||||||||||||
Zfish     1 MEKYEKISKIGEGSYGVVFKCRNKDTGQIVAIKKFVESEDDPIIKKIALREIRMLKQLKHPNLVN 65

Human    67 LLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPE 131
            |:|||||||:|||||||||||||:|||||.||||||:||||.||||||||||||.||||||||||
Zfish    66 LMEVFRRKRKLHLVFEYCDHTVLNELDRYPRGVPEHMVKSIIWQTLQAVNFCHKQNCIHRDVKPE 130

Human   132 NILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAEL 196
            |||||||.|||||||||||:||||.|||||.|||||||:||||||||||||||||||:|||||||
Zfish   131 NILITKHQVIKLCDFGFARILTGPCDYYTDCVATRWYRAPELLVGDTQYGPPVDVWAVGCVFAEL 195

Human   197 LSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPA 261
            |||.||||||||||||||||||||:|||||||||||||:||||.:|:|::|||||||:||:||.|
Zfish   196 LSGAPLWPGKSDVDQLYLIRKTLGELIPRHQQVFSTNQFFSGVCVPEPQEMEPLELKYPNLSYQA 260

Human   262 LGLLKGCLHMDPTQRLTCEQLLHHPYFENIR-EIEDLAKEHNKPTRKTLRKSRKHHCFTETSKLQ 325
            |.|:||||.|||.:||:|||||..|||:::| |.|.:.:|.::  :|..|:.|||      ....
Zfish   261 LSLMKGCLRMDPAERLSCEQLLEQPYFDSLREESESVTRELDR--KKRTRQPRKH------LPPG 317

Human   326 YLPQLTGSSILPALDNKKYYCDTKKLNYRFPNI 358
            |||||..|::.||::|::.|.:.:|.||..|||
Zfish   318 YLPQLASSTVFPAVENRRNYNNLRKFNYHLPNI 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDKL1	XP_005268214.1	STKc_CDKL1_4	3..288	CDD:270837	248/284 (87%)
cdkl1	NP_001003773.1	STKc_CDKL1_4	2..287	CDD:270837	248/284 (87%)
		Pkinase	4..287	CDD:278497	246/282 (87%)
		[NKR]KIAxRE	45..51		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..318		8/32 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194329359
Domainoid	1	1.000	534	1.000	Domainoid score	I2318
eggNOG	1	0.900	-	-		E1_KOG0593
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55805
Inparanoid	1	1.050	579	1.000	Inparanoid score	I5525
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG52261
OrthoDB	1	1.010	-	-		D245642at7742
OrthoFinder	1	1.000	-	-		FOG0004639
OrthoInspector	1	1.000	-	-		oto47499
orthoMCL	1	0.900	-	-		OOG6_101283
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3254
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.270