Protein Alignment CDKL1 and cka1

DIOPT Version :10

• Sequence 1: NP_004187.3
• Gene: CDKL1 / 8814
• HGNCID: 1781
• Length: 357
• Species: Homo sapiens
• Sequence 2: NP_593642.1
• Gene: cka1 / 2541972
• PomBaseID: SPAC23C11.11
• Length: 332
• Species: Schizosaccharomyces pombe
• Alignment Length: 322
• Identity: 95/322 - (29%)
• Similarity: 158/322 - (49%)
• Gaps: 62/322 - (19%)

Human     2 EKYEKIGKIGEGSYGVVFKCRN--RDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK-HPNL 63
            :.||.|.|:|.|.|..||:..|  .::..|:.:.|       ||..|...|||::|:.|. .||:
pombe    41 DNYEIIRKVGRGKYSEVFEGLNVLNNSKCIIKVLK-------PVKYKKIKREIKILQNLAGGPNI 98

Human    64 VNLLEVFR--RKRRLHLVFEYCDH----TVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNC 122
            ::||::.|  ..:...|:||:.|:    |:...|..|.       ::..:::.|:|::|||....
pombe    99 ISLLDIVRDPESKTPSLIFEFVDNIDFRTLYPTLSDYD-------IRYYSYELLKALDFCHSRGI 156

Human   123 IHRDVKPENILIT-KHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVW 186
            :||||||.|::|. |...::|.|:|.|.......:|.. .||:|:::.|||||...:|...:|:|
pombe   157 MHRDVKPHNVMIDHKKRKLRLIDWGLAEFYHAGMEYNV-RVASRYFKGPELLVDFREYDYSLDIW 220

Human   187 AIGCVFAELL-SGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLE 250
            :.|.:||.|: .....:.|:.:.|||..|.|.||.     .::|:..|.:..|          |:
pombe   221 SFGVMFAALIFKKDTFFRGRDNYDQLVKIAKVLGT-----DELFAYVQKYQIV----------LD 270

Human   251 LKFPNI--SYP-------------------ALGLLKGCLHMDPTQRLTCEQLLHHPYFENIR 291
            .::.||  .||                   |:.||...|..|..:||||::.:.||||:.::
pombe   271 RQYDNILGQYPKRDWYSFVNRDNRSLANDEAIDLLNRLLRYDHQERLTCQEAMAHPYFQVLK 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL1	NP_004187.3	STKc_CDKL1_4	2..287	CDD:270837	93/316 (29%)
		[NKR]KIAxRE	45..51		1/5 (20%)
cka1	NP_593642.1	STKc_CK2_alpha	24..329	CDD:271034	94/317 (30%)