Protein Alignment CDKL1 and lsk1

DIOPT Version :10

• Sequence 1: NP_004187.3
• Gene: CDKL1 / 8814
• HGNCID: 1781
• Length: 357
• Species: Homo sapiens
• Sequence 2: NP_594393.1
• Gene: lsk1 / 2541672
• PomBaseID: SPAC2F3.15
• Length: 593
• Species: Schizosaccharomyces pombe
• Alignment Length: 329
• Identity: 113/329 - (34%)
• Similarity: 175/329 - (53%)
• Gaps: 35/329 - (10%)

Human     4 YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKF-LESEDD--PVIKKIALREIRMLKQLKHPNLVN 65
            ||||.:||||:||.|:|..|..||.:||:|:. ||.|.|  |:   ..:||:::|::|:|.|:|.
pombe   277 YEKIDQIGEGTYGKVYKAINTVTGDLVALKRIRLEQEKDGFPI---TTVREVKILQRLRHKNIVR 338

Human    66 LLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPE 130
            |||:...|..:::||||.||.:...|...|.......:|.::.|..:|:.:.|....:|||:|..
pombe   339 LLEIMVEKSSVYMVFEYMDHDLTGVLLNSQLHFTPGNIKHLSKQIFEALAYLHHRGVLHRDIKGS 403

Human   131 NILITKHSVIKLCDFGFARLLT-GPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAE 194
            |||:..:..:|..|||.||..| ..|..||:.|.|.|:|.||||:|:|.|...||:|:.||:..|
pombe   404 NILLNNNGDLKFADFGLARFNTSSKSANYTNRVITLWFRPPELLLGETAYDTAVDIWSAGCIVME 468

Human   195 LLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVK-IPDPEDMEPLELK------ 252
            |.:|.|.:.|:.::.||.:|...:|.     ..|.|    :..|| :|..|.::|:|.|
pombe   469 LFTGKPFFQGRDEISQLEVIYDMMGT-----PDVHS----WPEVKNLPWYELLKPVEEKKSRFVE 524

Human   253 -FPNISYP-ALGLLKGCLHMDPTQRLTCEQLLHHPYFEN----------IREIEDLAKEHNKPTR 305
             |..|..| |:.|.:..|.::|..|.:..:.|.|.||.:          ::.::....|.....|
pombe   525 TFKEILSPAAIDLCQKLLALNPFCRPSAHETLMHEYFTSESPPPEPAVILKNMQGSWHEWESKKR 589

Human   306 KTLR 309
            |:.|
pombe   590 KSKR 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL1	NP_004187.3	STKc_CDKL1_4	2..287	CDD:270837	107/295 (36%)
		[NKR]KIAxRE	45..51		0/5 (0%)
lsk1	NP_594393.1	STKc_CDK9_like	277..561	CDD:270832	107/295 (36%)