Protein Alignment CDKL1 and cdk11

DIOPT Version :10

• Sequence 1: NP_004187.3
• Gene: CDKL1 / 8814
• HGNCID: 1781
• Length: 357
• Species: Homo sapiens
• Sequence 2: NP_595739.1
• Gene: cdk11 / 2540799
• PomBaseID: SPBC18H10.15
• Length: 398
• Species: Schizosaccharomyces pombe
• Alignment Length: 294
• Identity: 108/294 - (36%)
• Similarity: 165/294 - (56%)
• Gaps: 12/294 - (4%)

Human     1 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVN 65
            ::.||.:.||.|||||:|::..::.|..:||:||.....:.......:||||..|..::|.|:|.
pombe    71 IDDYEILEKIEEGSYGIVYRGLDKSTNTLVALKKIKFDPNGIGFPITSLREIESLSSIRHDNIVE 135

Human    66 LLEVFRRK--RRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVK 128
            |.:|...|  :.::||.|:.:|.:...||.......:..||::..|.|.|..|.|.|..:|||:|
pombe   136 LEKVVVGKDLKDVYLVMEFMEHDLKTLLDNMPEDFLQSEVKTLMLQLLAATAFMHHHWYLHRDLK 200

Human   129 PENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFA 193
            |.|:|:.....|||.|||.||.::.|....|..|.|.|||:||||:|...||..:|:|:|||:||
pombe   201 PSNLLMNNTGEIKLADFGLARPVSEPKSSLTRLVVTLWYRAPELLLGAPSYGKEIDMWSIGCIFA 265

Human   194 ELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYF-----SGVKIPDPEDMEPLELKF 253
            |:::..||:.|||::||||.|...||  .|..::   ..|||     :.:|.|.......:....
pombe   266 EMITRTPLFSGKSELDQLYKIFNLLG--YPTREE---WPQYFLLPYANKIKHPTVPTHSKIRTSI 325

Human   254 PNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYF 287
            ||::..|..||...|.::|.:|::.::.|.||||
pombe   326 PNLTGNAYDLLNRLLSLNPAKRISAKEALEHPYF 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDKL1	NP_004187.3	STKc_CDKL1_4	2..287	CDD:270837	106/291 (36%)
		[NKR]KIAxRE	45..51		1/5 (20%)
cdk11	NP_595739.1	STKc_CDC2L1	68..359	CDD:173741	106/292 (36%)